ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADORA2A
Previous Symbol	ADORA2
Symbol Alias	RDC8
Approved Name	adenosine A2a receptor
Location	22q11.23
Position	chr22:24813847-24838328, +
External Links	HGNC: 263 Entrez Gene: 135 Ensembl: ENSG00000128271 UCSC: uc002zzy.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_37	chr22:22020325-23326630 (NCBI Build 36.1 (hg18))	1306306	22q11.23	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 69)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 69)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030673	axolemma	Cellular Component		2
GO:0019899	enzyme binding	Molecular Function	IPI[16339847]	47
GO:0016020	membrane	Cellular Component	TAS[10051547]	139
GO:0014069	postsynaptic density	Cellular Component		23
GO:0014061	regulation of norepinephrine secretion	Biological Process		1
GO:0014057	positive regulation of acetylcholine secretion	Biological Process		1
GO:0014049	positive regulation of glutamate secretion	Biological Process		1
GO:0012505	endomembrane system	Cellular Component		16
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0008015	blood circulation	Biological Process	TAS[9262401]	12
GO:0007626	locomotory behavior	Biological Process		24
GO:0007600	sensory perception	Biological Process	TAS[9262401]	5
GO:0007596	blood coagulation	Biological Process	TAS[10899090]	83
GO:0007417	central nervous system development	Biological Process	TAS[10945659]	22
GO:0007271	synaptic transmission, cholinergic	Biological Process		8
GO:0007267	cell-cell signaling	Biological Process	TAS[7818494]	38
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Biological Process		9
GO:0043524	negative regulation of neuron apoptotic process	Biological Process		19
GO:0043025	neuronal cell body	Cellular Component		51
GO:0043116	negative regulation of vascular permeability	Biological Process		4
GO:0042734	presynaptic membrane	Cellular Component		15
GO:0042755	eating behavior	Biological Process		7
GO:0042311	vasodilation	Biological Process		3
GO:0042493	response to drug	Biological Process		68
GO:0035815	positive regulation of renal sodium excretion	Biological Process		3
GO:0040013	negative regulation of locomotion	Biological Process		2
GO:0035249	synaptic transmission, glutamatergic	Biological Process		7
GO:0035810	positive regulation of urine volume	Biological Process		3
GO:0032230	positive regulation of synaptic transmission, GABAergic	Biological Process		4
GO:0032279	asymmetric synapse	Cellular Component		4
GO:0031000	response to caffeine	Biological Process		6
GO:0031802	type 5 metabotropic glutamate receptor binding	Molecular Function		1
GO:0001963	synaptic transmission, dopaminergic	Biological Process		7
GO:0001609	G-protein coupled adenosine receptor activity	Molecular Function		1
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	Biological Process	TAS[10899090]	13
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	Biological Process		8
GO:0007190	activation of adenylate cyclase activity	Biological Process		9
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	Biological Process		8
GO:0006915	apoptotic process	Biological Process	TAS[7818494]	111
GO:0006954	inflammatory response	Biological Process	TAS[8360491]	51
GO:0006968	cellular defense response	Biological Process	TAS[10051547]	12
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	Biological Process		16
GO:0006171	cAMP biosynthetic process	Biological Process	TAS[10899090]	2
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0006469	negative regulation of protein kinase activity	Biological Process		13
GO:0006909	phagocytosis	Biological Process	TAS[8360491]	5
GO:0001975	response to amphetamine	Biological Process		16
GO:0005515	protein binding	Molecular Function	IPI[19632986]	910
GO:0005886	plasma membrane	Cellular Component	IDA[16339847]	772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8794889]	220
GO:0050714	positive regulation of protein secretion	Biological Process		5
GO:0048812	neuron projection morphogenesis	Biological Process		7
GO:0051393	alpha-actinin binding	Molecular Function		4
GO:0050728	negative regulation of inflammatory response	Biological Process		11
GO:0051924	regulation of calcium ion transport	Biological Process		9
GO:0051881	regulation of mitochondrial membrane potential	Biological Process		3
GO:0060079	regulation of excitatory postsynaptic membrane potential	Biological Process		9
GO:0051968	positive regulation of synaptic transmission, glutamatergic	Biological Process		8
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0044446	intracellular organelle part	Cellular Component	IDA[16339847]	1
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0046636	negative regulation of alpha-beta T cell activation	Biological Process		1
GO:0048143	astrocyte activation	Biological Process		1
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0048786	presynaptic active zone	Cellular Component		4
GO:0048167	regulation of synaptic plasticity	Biological Process		9
GO:0060080	regulation of inhibitory postsynaptic membrane potential	Biological Process		5
GO:0060134	prepulse inhibition	Biological Process		10
GO:2001235	positive regulation of apoptotic signaling pathway	Biological Process		2

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04270	Vascular smooth muscle contraction	33	The vascular smooth muscle cell (VSMC) is a highly specializ...... The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. More...
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with ADORA2A (count: 66)

Gene Symbol	Pathway Count	Pathway List
DRD2	12	postsynaptic density; negative regulation of cell proliferation; locomotory behavior; response to drug; positive regulation of renal sodium excretion; positive regulation of urine volume; synaptic transmission, dopaminergic; response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; prepulse inhibition;
GRIN2A	10	postsynaptic density; presynaptic membrane; response to drug; response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; regulation of synaptic plasticity;
DRD1	10	response to drug; synaptic transmission, dopaminergic; adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition;
NTRK2	9	postsynaptic density; negative regulation of neuron apoptotic process; neuronal cell body; activation of adenylate cyclase activity; transmembrane receptor protein tyrosine kinase signaling pathway; integral to plasma membrane; positive regulation of synaptic transmission, glutamatergic; nerve growth factor receptor signaling pathway; presynaptic active zone;
DRD3	9	locomotory behavior; response to drug; positive regulation of renal sodium excretion; synaptic transmission, dopaminergic; response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; prepulse inhibition;
GRIK1	9	central nervous system development; presynaptic membrane; synaptic transmission, glutamatergic; positive regulation of synaptic transmission, GABAergic; plasma membrane; integral to plasma membrane; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; regulation of inhibitory postsynaptic membrane potential;
ADRB1	9	adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; apoptotic process; protein binding; plasma membrane; integral to plasma membrane; regulation of calcium ion transport; protein heterodimerization activity; regulation of inhibitory postsynaptic membrane potential;
DRD4	8	membrane; neuronal cell body; synaptic transmission, dopaminergic; response to amphetamine; protein binding; plasma membrane; integral to plasma membrane; regulation of inhibitory postsynaptic membrane potential;
GJA1	8	negative regulation of cell proliferation; cell-cell signaling; apoptotic process; protein binding; plasma membrane; integral to plasma membrane; neuron projection morphogenesis; regulation of calcium ion transport;
SLC18A2	7	enzyme binding; membrane; locomotory behavior; neuronal cell body; response to amphetamine; plasma membrane; integral to plasma membrane;
ACHE	7	membrane; synaptic transmission, cholinergic; presynaptic membrane; protein binding; plasma membrane; positive regulation of protein secretion; postsynaptic membrane;
ADCY4	7	membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; adenylate cyclase-activating G-protein coupled receptor signaling pathway; cAMP biosynthetic process; protein binding; plasma membrane; nerve growth factor receptor signaling pathway;
CHRM1	7	membrane; postsynaptic density; asymmetric synapse; protein kinase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; postsynaptic membrane;
CHRNA4	7	membrane; locomotory behavior; synaptic transmission, cholinergic; neuronal cell body; plasma membrane; postsynaptic membrane; regulation of inhibitory postsynaptic membrane potential;
CHRNA3	7	postsynaptic density; locomotory behavior; synaptic transmission, cholinergic; neuronal cell body; plasma membrane; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane;
GRIN2B	7	postsynaptic density; protein binding; plasma membrane; integral to plasma membrane; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; regulation of synaptic plasticity;
GRM5	7	postsynaptic density; locomotory behavior; negative regulation of locomotion; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of transcription, DNA-dependent; plasma membrane; integral to plasma membrane;
ADRA1A	7	negative regulation of cell proliferation; cell-cell signaling; response to drug; apoptotic process; plasma membrane; integral to plasma membrane; protein heterodimerization activity;
BDKRB2	7	blood circulation; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway; protein binding; plasma membrane; integral to plasma membrane; protein heterodimerization activity;
ADRA1B	7	locomotory behavior; cell-cell signaling; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; response to amphetamine; plasma membrane; integral to plasma membrane; protein heterodimerization activity;
SLC6A3	7	locomotory behavior; neuronal cell body; response to drug; protein binding; plasma membrane; integral to plasma membrane; prepulse inhibition;
ADRB3	7	eating behavior; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; protein binding; plasma membrane; integral to plasma membrane;
OXTR	7	eating behavior; response to drug; positive regulation of synaptic transmission, GABAergic; response to amphetamine; plasma membrane; integral to plasma membrane; positive regulation of synaptic transmission, glutamatergic;
APOA1	6	enzyme binding; blood coagulation; response to drug; protein binding; plasma membrane; negative regulation of inflammatory response;
CXCR2	6	membrane; apoptotic process; inflammatory response; cellular defense response; plasma membrane; integral to plasma membrane;
GRIN3A	6	membrane; postsynaptic density; neuronal cell body; protein binding; postsynaptic membrane; prepulse inhibition;
VEGFB	6	membrane; blood coagulation; negative regulation of neuron apoptotic process; response to drug; protein binding; protein heterodimerization activity;
IL6	6	negative regulation of cell proliferation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to drug; response to caffeine; inflammatory response; negative regulation of protein kinase activity;
OPRM1	6	negative regulation of cell proliferation; locomotory behavior; sensory perception; protein binding; plasma membrane; integral to plasma membrane;
PTPRJ	6	negative regulation of cell proliferation; blood coagulation; negative regulation of vascular permeability; protein binding; plasma membrane; integral to plasma membrane;
ADRA2C	6	blood coagulation; cell-cell signaling; protein binding; plasma membrane; integral to plasma membrane; protein heterodimerization activity;
CCR5	6	cell-cell signaling; inflammatory response; cellular defense response; protein binding; plasma membrane; integral to plasma membrane;
SNCA	6	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of neuron apoptotic process; response to drug; protein binding; plasma membrane; regulation of excitatory postsynaptic membrane potential;
ADAM8	6	negative regulation of neuron apoptotic process; inflammatory response; protein binding; plasma membrane; integral to plasma membrane; positive regulation of protein secretion;
ILK	6	negative regulation of neuron apoptotic process; neuronal cell body; negative regulation of protein kinase activity; protein binding; plasma membrane; neuron projection morphogenesis;
NGF	6	negative regulation of neuron apoptotic process; response to drug; apoptotic process; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway; nerve growth factor receptor signaling pathway;
GRM7	6	presynaptic membrane; asymmetric synapse; plasma membrane; integral to plasma membrane; postsynaptic membrane; presynaptic active zone;
NRXN1	6	presynaptic membrane; protein binding; plasma membrane; integral to plasma membrane; positive regulation of synaptic transmission, glutamatergic; prepulse inhibition;
GRID2	6	synaptic transmission, glutamatergic; plasma membrane; integral to plasma membrane; regulation of excitatory postsynaptic membrane potential; postsynaptic membrane; prepulse inhibition;
DRD5	6	synaptic transmission, dopaminergic; adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; response to amphetamine; plasma membrane; integral to plasma membrane;
ADRB2	6	adenylate cyclase-modulating G-protein coupled receptor signaling pathway; adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; protein binding; plasma membrane; integral to plasma membrane;
EDNRA	5	membrane; activation of adenylate cyclase activity; protein kinase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane;
GOPC	5	membrane; postsynaptic density; protein binding; plasma membrane; postsynaptic membrane;
PIK3CG	5	membrane; blood coagulation; inflammatory response; protein binding; plasma membrane;
VEGFA	5	membrane; blood coagulation; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; protein binding; protein heterodimerization activity;
ARRB2	5	postsynaptic density; blood coagulation; protein binding; plasma membrane; postsynaptic membrane;
CACNA1C	5	postsynaptic density; neuronal cell body; protein binding; plasma membrane; alpha-actinin binding;
NLGN1	5	postsynaptic density; positive regulation of synaptic transmission, GABAergic; integral to plasma membrane; positive regulation of synaptic transmission, glutamatergic; postsynaptic membrane;
SLC6A4	5	endomembrane system; response to drug; protein binding; plasma membrane; integral to plasma membrane;
FOSL1	5	negative regulation of cell proliferation; presynaptic membrane; response to drug; cellular defense response; protein binding;
CHRNB4	5	locomotory behavior; synaptic transmission, cholinergic; plasma membrane; integral to plasma membrane; postsynaptic membrane;
TH	5	locomotory behavior; eating behavior; synaptic transmission, dopaminergic; response to amphetamine; protein binding;
ADRA2A	5	blood coagulation; protein binding; plasma membrane; integral to plasma membrane; protein heterodimerization activity;
ADRA2B	5	blood coagulation; cell-cell signaling; protein binding; plasma membrane; integral to plasma membrane;
PDE2A	5	blood coagulation; negative regulation of vascular permeability; presynaptic membrane; protein binding; plasma membrane;
SHC3	5	central nervous system development; synaptic transmission, glutamatergic; transmembrane receptor protein tyrosine kinase signaling pathway; protein binding; nerve growth factor receptor signaling pathway;
CYBA	5	neuronal cell body; response to drug; inflammatory response; protein binding; protein heterodimerization activity;
GSK3B	5	neuronal cell body; response to drug; protein binding; plasma membrane; nerve growth factor receptor signaling pathway;
RTN4	5	neuronal cell body; apoptotic process; protein binding; plasma membrane; nerve growth factor receptor signaling pathway;
TJP1	5	negative regulation of vascular permeability; response to drug; apoptotic process; protein binding; plasma membrane;
ADAM17	5	response to drug; protein binding; plasma membrane; integral to plasma membrane; nerve growth factor receptor signaling pathway;
BAD	5	response to drug; apoptotic process; protein binding; protein heterodimerization activity; nerve growth factor receptor signaling pathway;
RELA	5	response to drug; inflammatory response; cellular defense response; protein binding; nerve growth factor receptor signaling pathway;
GNAL	5	response to caffeine; adenylate cyclase-activating G-protein coupled receptor signaling pathway; activation of adenylate cyclase activity; response to amphetamine; plasma membrane;
PRKD1	5	apoptotic process; inflammatory response; protein binding; plasma membrane; integral to plasma membrane;
MUSK	5	transmembrane receptor protein tyrosine kinase signaling pathway; regulation of transcription, DNA-dependent; protein binding; integral to plasma membrane; postsynaptic membrane;

Genes shared at least 2 KEGG pathways with ADORA2A (count: 40)

Gene Symbol	Pathway Count	Pathway List
ADRA1A	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRA1B	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRA1D	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
EDNRA	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADCY4	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1C	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1D	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1F	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1S	2	Vascular smooth muscle contraction; Calcium signaling pathway;
ITPR1	2	Vascular smooth muscle contraction; Calcium signaling pathway;
ITPR2	2	Vascular smooth muscle contraction; Calcium signaling pathway;
PLCB2	2	Vascular smooth muscle contraction; Calcium signaling pathway;
PLCB3	2	Vascular smooth muscle contraction; Calcium signaling pathway;
PRKCB	2	Vascular smooth muscle contraction; Calcium signaling pathway;

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Region: chr22:24813847..24838328 View in gBrowse