ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADRBK1
Symbol Alias	GRK2, BARK1
Approved Name	adrenergic, beta, receptor kinase 1
Location	11q13
Position	chr11:67033881-67054029, +
External Links	HGNC: 289 Entrez Gene: 156 Ensembl: ENSG00000173020 UCSC: uc009yrn.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.0879, global P-value=0.485, WHAP TDT P_sum P-value=0.629, no SNP with nominal P-value<0.05 located in this gene	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 29)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 29)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	Cellular Component	IDA[17986524]	690
GO:0005829	cytosol	Cellular Component		447
GO:0005886	plasma membrane	Cellular Component		772
GO:0007165	signal transduction	Biological Process		171
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process		25
GO:0007202	activation of phospholipase C activity	Biological Process		12
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	Biological Process		3
GO:0007217	tachykinin receptor signaling pathway	Biological Process	IDA[17986524]	2
GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway	Biological Process		2
GO:0003108	negative regulation of the force of heart contraction by chemical signal	Biological Process	IMP[15051637]	1
GO:0004672	protein kinase activity	Molecular Function		27
GO:0004703	G-protein coupled receptor kinase activity	Molecular Function		2
GO:0005515	protein binding	Molecular Function	IPI[17986524]	910
GO:0005524	ATP binding	Molecular Function		228
GO:0005543	phospholipid binding	Molecular Function		61
GO:0038032	termination of G-protein coupled receptor signaling pathway	Biological Process		9
GO:0033605	positive regulation of catecholamine secretion	Biological Process		1
GO:0047696	beta-adrenergic receptor kinase activity	Molecular Function		2
GO:0045988	negative regulation of striated muscle contraction	Biological Process	IMP[15051637]	1
GO:0060048	cardiac muscle contraction	Biological Process	IMP[15051637]	9
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process		26
GO:0007507	heart development	Biological Process		23
GO:0018105	peptidyl-serine phosphorylation	Biological Process		12
GO:0016020	membrane	Cellular Component		139
GO:0031623	receptor internalization	Biological Process		10
GO:0018107	peptidyl-threonine phosphorylation	Biological Process		3
GO:0031755	Edg-2 lysophosphatidic acid receptor binding	Molecular Function	IDA[19306925]	1
GO:0031694	alpha-2A adrenergic receptor binding	Molecular Function		3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...

Genes shared at least 5 GO terms with ADRBK1 (count: 52)

Gene Symbol	Pathway Count	Pathway List
ADCY4	10	cytoplasm; plasma membrane; signal transduction; epidermal growth factor receptor signaling pathway; activation of phospholipase C activity; protein binding; ATP binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; membrane;
GSK3B	9	cytoplasm; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; protein binding; ATP binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; peptidyl-serine phosphorylation;
MAPK1	9	cytoplasm; cytosol; signal transduction; epidermal growth factor receptor signaling pathway; protein binding; ATP binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; peptidyl-serine phosphorylation;
PRKAR2B	8	cytoplasm; cytosol; plasma membrane; signal transduction; epidermal growth factor receptor signaling pathway; activation of phospholipase C activity; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
PRKD1	8	cytoplasm; cytosol; plasma membrane; signal transduction; protein binding; ATP binding; phospholipid binding; peptidyl-serine phosphorylation;
TGFBR1	8	plasma membrane; signal transduction; protein kinase activity; protein binding; ATP binding; heart development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation;
ADRBK2	8	signal transduction; protein kinase activity; G-protein coupled receptor kinase activity; ATP binding; phospholipid binding; termination of G-protein coupled receptor signaling pathway; beta-adrenergic receptor kinase activity; receptor internalization;
ARHGEF12	7	cytoplasm; cytosol; protein binding; phospholipid binding; termination of G-protein coupled receptor signaling pathway; nerve growth factor receptor signaling pathway; membrane;
PIK3CG	7	cytoplasm; cytosol; plasma membrane; protein kinase activity; protein binding; ATP binding; membrane;
RPS6KB2	7	cytoplasm; signal transduction; epidermal growth factor receptor signaling pathway; protein kinase activity; ATP binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
BCAR1	6	cytoplasm; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; protein binding; nerve growth factor receptor signaling pathway;
CBL	6	cytoplasm; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; protein binding; fibroblast growth factor receptor signaling pathway;
ILK	6	cytoplasm; cytosol; plasma membrane; protein binding; ATP binding; peptidyl-serine phosphorylation;
PAK1	6	cytoplasm; cytosol; plasma membrane; protein kinase activity; protein binding; ATP binding;
PLCE1	6	cytoplasm; cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; protein binding; heart development;
PRKCB	6	cytoplasm; cytosol; plasma membrane; signal transduction; protein binding; ATP binding;
PRKG1	6	cytoplasm; cytosol; plasma membrane; signal transduction; protein binding; ATP binding;
SMG1	6	cytoplasm; cytosol; protein kinase activity; protein binding; ATP binding; peptidyl-serine phosphorylation;
SNCA	6	cytoplasm; cytosol; plasma membrane; protein binding; phospholipid binding; receptor internalization;
BAD	6	cytosol; epidermal growth factor receptor signaling pathway; protein binding; phospholipid binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
ITK	6	cytosol; signal transduction; activation of phospholipase C activity; protein binding; ATP binding; phospholipid binding;
MAPK3	6	cytosol; epidermal growth factor receptor signaling pathway; protein binding; ATP binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
MAPK7	6	cytosol; signal transduction; protein binding; ATP binding; nerve growth factor receptor signaling pathway; peptidyl-serine phosphorylation;
PIK3R1	6	cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; protein binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
RIPK3	6	cytosol; plasma membrane; signal transduction; protein kinase activity; protein binding; ATP binding;
UBB	6	cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; protein binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
UBC	6	cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; protein binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
ERBB2	6	plasma membrane; signal transduction; epidermal growth factor receptor signaling pathway; protein binding; ATP binding; heart development;
ITPR2	6	plasma membrane; signal transduction; epidermal growth factor receptor signaling pathway; activation of phospholipase C activity; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
ITPR1	6	signal transduction; epidermal growth factor receptor signaling pathway; activation of phospholipase C activity; protein binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
ADAM17	5	cytoplasm; plasma membrane; epidermal growth factor receptor signaling pathway; protein binding; nerve growth factor receptor signaling pathway;
AIP	5	cytoplasm; cytosol; plasma membrane; signal transduction; protein binding;
AKAP10	5	cytoplasm; cytosol; plasma membrane; signal transduction; termination of G-protein coupled receptor signaling pathway;
ARRB2	5	cytoplasm; cytosol; plasma membrane; protein binding; receptor internalization;
EIF2B1	5	cytoplasm; cytosol; plasma membrane; protein binding; membrane;
GRB10	5	cytoplasm; cytosol; plasma membrane; protein binding; phospholipid binding;
NCK2	5	cytoplasm; cytosol; signal transduction; epidermal growth factor receptor signaling pathway; protein binding;
NEK6	5	cytoplasm; signal transduction; protein binding; ATP binding; peptidyl-serine phosphorylation;
RASA1	5	cytoplasm; cytosol; signal transduction; protein binding; phospholipid binding;
WWP1	5	cytoplasm; cytosol; plasma membrane; signal transduction; protein binding;
CAMK2D	5	cytosol; plasma membrane; ATP binding; cardiac muscle contraction; peptidyl-serine phosphorylation;
CSNK1E	5	cytosol; signal transduction; protein kinase activity; protein binding; ATP binding;
MAP2K3	5	cytosol; signal transduction; protein binding; ATP binding; cardiac muscle contraction;
MAPKAP1	5	cytosol; plasma membrane; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
PLK1	5	cytosol; protein kinase activity; protein binding; ATP binding; peptidyl-serine phosphorylation;
PRKAA1	5	cytosol; signal transduction; protein kinase activity; protein binding; ATP binding;
RICTOR	5	cytosol; epidermal growth factor receptor signaling pathway; protein binding; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
ROCK2	5	cytosol; plasma membrane; protein binding; ATP binding; phospholipid binding;
SYK	5	cytosol; plasma membrane; protein kinase activity; protein binding; ATP binding;
TRIO	5	cytosol; protein binding; ATP binding; phospholipid binding; nerve growth factor receptor signaling pathway;
EDNRA	5	plasma membrane; signal transduction; activation of phospholipase C activity; heart development; membrane;
ATM	5	signal transduction; protein binding; ATP binding; heart development; peptidyl-serine phosphorylation;

Genes shared at least 2 KEGG pathways with ADRBK1 (count: 16)

Gene Symbol	Pathway Count	Pathway List
ADRBK2	3	Endocytosis; Chemokine signaling pathway; Glutamatergic synapse;
ARRB1	2	Endocytosis; Chemokine signaling pathway;
ARRB2	2	Endocytosis; Chemokine signaling pathway;
CCR5	2	Endocytosis; Chemokine signaling pathway;
CXCR1	2	Endocytosis; Chemokine signaling pathway;
CXCR2	2	Endocytosis; Chemokine signaling pathway;
PLD1	2	Endocytosis; Glutamatergic synapse;
PLD2	2	Endocytosis; Glutamatergic synapse;
ADCY4	2	Chemokine signaling pathway; Glutamatergic synapse;
GNG10	2	Chemokine signaling pathway; Glutamatergic synapse;
GNG3	2	Chemokine signaling pathway; Glutamatergic synapse;
MAPK1	2	Chemokine signaling pathway; Glutamatergic synapse;
MAPK3	2	Chemokine signaling pathway; Glutamatergic synapse;
PLCB2	2	Chemokine signaling pathway; Glutamatergic synapse;
PLCB3	2	Chemokine signaling pathway; Glutamatergic synapse;
PRKCB	2	Chemokine signaling pathway; Glutamatergic synapse;

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Region: chr11:67033881..67054029 View in gBrowse