ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	APC
Symbol Alias	DP2, DP3, DP2.5
Approved Name	adenomatous polyposis coli
Previous Name	adenomatosis polyposis coli
Location	5q21-q22
Position	chr5:112043195-112203279, +
External Links	HGNC: 583 Entrez Gene: 324 UCSC: uc003kpy.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 33)

Literature-origin SNPs (count: 0)

LD-proxies (count: 33)

rs_ID	Location	Functional Annotation
rs565453	Chr5:112185393(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant
rs481789	Chr5:112186064(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant
rs411356	Chr5:112172219(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs2439591	Chr5:112089480(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs2464805	Chr5:112101793(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs580237	Chr5:112194032(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs2431238	Chr5:112124369(Fwd)	NMD_transcript_variant; intron_variant
rs2545169	Chr5:112149757(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs2909958	Chr5:112167941(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs2909786	Chr5:112168065(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs2909787	Chr5:112168130(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs368575	Chr5:112204896(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs2545162	Chr5:112158431(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs464708	Chr5:112154303(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs463229	Chr5:112201284(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs7213	Chr5:112203564(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs351769	Chr5:112199974(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs495794	Chr5:112201094(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs351770	Chr5:112199199(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs372492	Chr5:112198015(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs431287	Chr5:112197986(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs712668	Chr5:112197637(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs429427	Chr5:112194693(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs434157	Chr5:112191642(Fwd)	NMD_transcript_variant; intron_variant
rs497844	Chr5:112185491(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant
rs465899	Chr5:112177171(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; synonymous_variant
rs866006	Chr5:112176559(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; synonymous_variant
rs42427	Chr5:112176325(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; synonymous_variant
rs41115	Chr5:112175770(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; synonymous_variant
rs351771	Chr5:112164561(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant
rs501250	Chr5:112155793(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs2545165	Chr5:112153119(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs2952615	Chr5:112138888(Fwd)	NMD_transcript_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 73)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39
GO:0051493	regulation of cytoskeleton organization	Biological Process		32

GO terms by database search (count: 71)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051781	positive regulation of cell division	Biological Process		11
GO:0060041	retina development in camera-type eye	Biological Process		8
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	Biological Process	IMP[17227893]; NAS[11283619]	1
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	Biological Process		1
GO:0060070	canonical Wnt receptor signaling pathway	Biological Process	IC[9601641]; NAS[11035805]	13
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	Biological Process	IGI[12952940]	14
GO:0070830	tight junction assembly	Biological Process	NAS[18502210]	3
GO:0031122	cytoplasmic microtubule organization	Biological Process		3
GO:0031116	positive regulation of microtubule polymerization	Biological Process		6
GO:0030877	beta-catenin destruction complex	Cellular Component	IDA[16188939]	4
GO:0030858	positive regulation of epithelial cell differentiation	Biological Process		1
GO:0030335	positive regulation of cell migration	Biological Process	IMP[17192415]	29
GO:0030027	lamellipodium	Cellular Component	IDA[19151759]	27
GO:0019901	protein kinase binding	Molecular Function	IPI[8638126]	51
GO:0019887	protein kinase regulator activity	Molecular Function	IDA[11972058]	1
GO:0043065	positive regulation of apoptotic process	Biological Process	IMP[17227893]	34
GO:0042483	negative regulation of odontogenesis	Biological Process		1
GO:0035371	microtubule plus end	Cellular Component		3
GO:0035019	somatic stem cell maintenance	Biological Process		7
GO:0033077	T cell differentiation in thymus	Biological Process		3
GO:0032886	regulation of microtubule-based process	Biological Process		5
GO:0032587	ruffle membrane	Cellular Component	IDA[19151759]	12
GO:0031274	positive regulation of pseudopodium assembly	Biological Process	IMP[17192415]	3
GO:0045667	regulation of osteoblast differentiation	Biological Process		3
GO:0045670	regulation of osteoclast differentiation	Biological Process		2
GO:0045295	gamma-catenin binding	Molecular Function	IPI[7890674]	6
GO:0045296	cadherin binding	Molecular Function	IDA[7890674]	9
GO:0043588	skin development	Biological Process		7
GO:0044295	axonal growth cone	Cellular Component		3
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0043409	negative regulation of MAPK cascade	Biological Process		5
GO:0051171	regulation of nitrogen compound metabolic process	Biological Process		1
GO:0051276	chromosome organization	Biological Process		5
GO:0048538	thymus development	Biological Process		14
GO:0051010	microtubule plus-end binding	Molecular Function	IDA[19632184]	5
GO:0045785	positive regulation of cell adhesion	Biological Process		7
GO:0046716	muscle cell homeostasis	Biological Process		4
GO:0045732	positive regulation of protein catabolic process	Biological Process	IC[16188939]; IGI[12952940]	8
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process	IDA[8521819]	6
GO:0005634	nucleus	Cellular Component	IDA[12072559]	770
GO:0005515	protein binding	Molecular Function		910
GO:0005813	centrosome	Cellular Component	IDA[11283619]	71
GO:0005737	cytoplasm	Cellular Component		690
GO:0000776	kinetochore	Cellular Component	IDA[11283619]	15
GO:0000281	cytokinesis after mitosis	Biological Process	IMP[17570218]	4
GO:0001942	hair follicle development	Biological Process		4
GO:0001822	kidney development	Biological Process		16
GO:0006461	protein complex assembly	Biological Process	IDA[16188939]	28
GO:0005923	tight junction	Cellular Component	IDA[18502210]	15
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	Biological Process		9
GO:0006915	apoptotic process	Biological Process		111
GO:0005881	cytoplasmic microtubule	Cellular Component		8
GO:0005829	cytosol	Cellular Component		447
GO:0005913	cell-cell adherens junction	Cellular Component	IDA[16611247]	9
GO:0005886	plasma membrane	Cellular Component	IDA[16611247]	772
GO:0007094	mitotic cell cycle spindle assembly checkpoint	Biological Process	IMP[17227893]	6
GO:0007155	cell adhesion	Biological Process	NAS[8259518]	86
GO:0007409	axonogenesis	Biological Process		14
GO:0008013	beta-catenin binding	Molecular Function	IPI[7890674]	10
GO:0006974	response to DNA damage stimulus	Biological Process	IDA[14728717]	37
GO:0007026	negative regulation of microtubule depolymerization	Biological Process	IDA[11166179]; IMP[17192415]	7
GO:0007050	cell cycle arrest	Biological Process	IDA[8521819]	25
GO:0007091	mitotic metaphase/anaphase transition	Biological Process		4
GO:0009953	dorsal/ventral pattern formation	Biological Process		12
GO:0009954	proximal/distal pattern formation	Biological Process		5
GO:0016328	lateral plasma membrane	Cellular Component	IDA[12072559]	8
GO:0016477	cell migration	Biological Process	IMP[19151759]	24
GO:0008017	microtubule binding	Molecular Function	IDA[16188939]	32
GO:0008285	negative regulation of cell proliferation	Biological Process	IDA[8521819]	59
GO:0009798	axis specification	Biological Process		4
GO:0009952	anterior/posterior pattern specification	Biological Process		26

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05210	Colorectal cancer	11	Colorectal cancer (CRC) is the second largest cause of cance...... Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated DNA mismatch repair genes in HNPCC). More...
hsa05213	Endometrial cancer	12	Endometrial cancer (EC) is the most common gynaecological ma...... Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification. More...
hsa05217	Basal cell carcinoma	8	Cancer of the skin is the most common cancer in Caucasians a...... Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC. More...
hsa04810	Regulation of actin cytoskeleton	48
hsa04310	Wnt signaling pathway	22	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...
hsa05200	Pathways in cancer	52

Genes shared at least 5 GO terms with APC (count: 165)

Gene Symbol	Pathway Count	Pathway List
GSK3B	15	canonical Wnt receptor signaling pathway; negative regulation of canonical Wnt receptor signaling pathway; beta-catenin destruction complex; protein kinase binding; regulation of microtubule-based process; negative regulation of apoptotic process; positive regulation of protein catabolic process; nucleus; protein binding; centrosome; cytoplasm; cytosol; plasma membrane; beta-catenin binding; cell migration;
CLASP2	11	microtubule cytoskeleton organization; regulation of cytoskeleton organization; regulation of microtubule-based process; ruffle membrane; microtubule plus-end binding; protein binding; cytoplasm; cytoplasmic microtubule; cytosol; plasma membrane; negative regulation of microtubule depolymerization;
ARHGEF2	10	microtubule cytoskeleton organization; regulation of cytoskeleton organization; ruffle membrane; negative regulation of apoptotic process; protein binding; tight junction; apoptotic process; cytosol; negative regulation of microtubule depolymerization; microtubule binding;
CLASP1	10	microtubule cytoskeleton organization; regulation of cytoskeleton organization; microtubule plus-end binding; protein binding; centrosome; kinetochore; cytoplasmic microtubule; cytosol; negative regulation of microtubule depolymerization; microtubule binding;
MAPT	10	microtubule cytoskeleton organization; regulation of cytoskeleton organization; positive regulation of microtubule polymerization; protein kinase binding; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; cytosol; plasma membrane; microtubule binding;
MEN1	10	positive regulation of cell division; positive regulation of apoptotic process; negative regulation of cyclin-dependent protein kinase activity; nucleus; protein binding; cytoplasm; cytosol; response to DNA damage stimulus; cell cycle arrest; negative regulation of cell proliferation;
WNT11	10	canonical Wnt receptor signaling pathway; negative regulation of canonical Wnt receptor signaling pathway; tight junction assembly; positive regulation of cell migration; positive regulation of apoptotic process; negative regulation of apoptotic process; cytoplasm; plasma membrane; axis specification; anterior/posterior pattern specification;
CTNND1	10	negative regulation of canonical Wnt receptor signaling pathway; lamellipodium; cadherin binding; nucleus; protein binding; cytoplasm; cytosol; cell-cell adherens junction; plasma membrane; cell adhesion;
APBB1	10	lamellipodium; positive regulation of apoptotic process; nucleus; protein binding; cytoplasm; apoptotic process; plasma membrane; axonogenesis; response to DNA damage stimulus; cell cycle arrest;
PLK1	10	protein kinase binding; negative regulation of apoptotic process; negative regulation of cyclin-dependent protein kinase activity; nucleus; protein binding; centrosome; kinetochore; cytosol; mitotic metaphase/anaphase transition; microtubule binding;
MAPRE1	9	microtubule cytoskeleton organization; regulation of cytoskeleton organization; microtubule plus end; microtubule plus-end binding; protein binding; centrosome; cytoplasm; cytoplasmic microtubule; cytosol;
NF2	9	regulation of cytoskeleton organization; lamellipodium; ruffle membrane; negative regulation of MAPK cascade; nucleus; protein binding; cytoplasm; plasma membrane; negative regulation of cell proliferation;
TFAP2A	9	positive regulation of cell migration; skin development; negative regulation of apoptotic process; nucleus; protein binding; centrosome; cytoplasm; kidney development; negative regulation of cell proliferation;
TGFBR1	9	negative regulation of apoptotic process; thymus development; protein binding; kidney development; tight junction; apoptotic process; plasma membrane; cell cycle arrest; anterior/posterior pattern specification;
TJP1	9	nucleus; protein binding; cytoplasm; tight junction; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; cytosol; cell-cell adherens junction; plasma membrane;
PAFAH1B1	8	microtubule cytoskeleton organization; nucleus; protein binding; centrosome; cytoplasm; kinetochore; cytosol; microtubule binding;
MAPK1	8	regulation of cytoskeleton organization; positive regulation of cell migration; nucleus; protein binding; cytoplasm; apoptotic process; cytosol; response to DNA damage stimulus;
TSC1	8	regulation of cytoskeleton organization; lamellipodium; protein binding; cytoplasm; kidney development; cytosol; cell cycle arrest; negative regulation of cell proliferation;
CDH2	8	negative regulation of canonical Wnt receptor signaling pathway; lamellipodium; gamma-catenin binding; cell-cell adherens junction; plasma membrane; cell adhesion; beta-catenin binding; cell migration;
BCAR1	8	positive regulation of cell migration; protein kinase binding; protein binding; cytoplasm; cytosol; plasma membrane; cell adhesion; cell migration;
ILK	8	positive regulation of cell migration; lamellipodium; protein kinase binding; protein binding; cytoplasm; cytosol; plasma membrane; cell cycle arrest;
PTPRJ	8	protein kinase binding; ruffle membrane; gamma-catenin binding; positive regulation of cell adhesion; protein binding; plasma membrane; beta-catenin binding; negative regulation of cell proliferation;
BARD1	8	positive regulation of apoptotic process; negative regulation of apoptotic process; positive regulation of protein catabolic process; nucleus; protein binding; cytoplasm; response to DNA damage stimulus; cell cycle arrest;
HES1	8	somatic stem cell maintenance; thymus development; nucleus; protein binding; cytoplasm; protein complex assembly; cell adhesion; cell migration;
AATF	8	negative regulation of apoptotic process; nucleus; protein binding; centrosome; cytoplasm; apoptotic process; cell adhesion; response to DNA damage stimulus;
TNFAIP3	8	negative regulation of apoptotic process; positive regulation of protein catabolic process; negative regulation of cyclin-dependent protein kinase activity; nucleus; protein binding; centrosome; cytoplasm; cytosol;
CCDC88A	7	microtubule cytoskeleton organization; regulation of cytoskeleton organization; lamellipodium; cytosol; plasma membrane; cell migration; microtubule binding;
CDK5RAP2	7	microtubule cytoskeleton organization; protein kinase binding; protein binding; centrosome; cytoplasm; cytosol; microtubule binding;
KATNB1	7	microtubule cytoskeleton organization; regulation of cytoskeleton organization; centrosome; cytoplasm; plasma membrane; negative regulation of microtubule depolymerization; microtubule binding;
KIF2C	7	microtubule cytoskeleton organization; microtubule plus-end binding; nucleus; protein binding; kinetochore; cytoplasmic microtubule; cytosol;
PRC1	7	microtubule cytoskeleton organization; protein kinase binding; nucleus; protein binding; cytoplasm; plasma membrane; microtubule binding;
TUBGCP2	7	microtubule cytoskeleton organization; nucleus; protein binding; centrosome; protein complex assembly; cytoplasmic microtubule; cytosol;
VEGFA	7	positive regulation of cell division; positive regulation of cell migration; negative regulation of apoptotic process; positive regulation of cell adhesion; protein binding; cytoplasm; kidney development;
NCK1	7	regulation of cytoskeleton organization; nucleus; protein binding; cytoplasm; cytosol; plasma membrane; cell migration;
CCND1	7	canonical Wnt receptor signaling pathway; protein kinase binding; nucleus; protein binding; tight junction; cytosol; response to DNA damage stimulus;
DACT1	7	negative regulation of canonical Wnt receptor signaling pathway; beta-catenin destruction complex; positive regulation of protein catabolic process; nucleus; protein binding; cytoplasm; beta-catenin binding;
ADAM17	7	positive regulation of cell migration; T cell differentiation in thymus; ruffle membrane; protein binding; cytoplasm; plasma membrane; cell adhesion;
CTNNA2	7	lamellipodium; cadherin binding; protein binding; cytoplasm; cytosol; cell-cell adherens junction; axonogenesis;
INPPL1	7	lamellipodium; protein binding; cytoplasm; cytosol; plasma membrane; cell adhesion; negative regulation of cell proliferation;
PTPRK	7	protein kinase binding; gamma-catenin binding; protein binding; cell adhesion; beta-catenin binding; cell migration; negative regulation of cell proliferation;
RELA	7	protein kinase binding; negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; hair follicle development; cytosol;
RPS3	7	protein kinase binding; ruffle membrane; nucleus; protein binding; cytoplasm; cytosol; response to DNA damage stimulus;
PMAIP1	7	positive regulation of apoptotic process; nucleus; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; cytosol; response to DNA damage stimulus;
WWOX	7	positive regulation of apoptotic process; nucleus; protein binding; cytoplasm; apoptotic process; cytosol; plasma membrane;
YAP1	7	somatic stem cell maintenance; negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; cytosol; response to DNA damage stimulus;
ANK3	7	cadherin binding; protein binding; cytokinesis after mitosis; tight junction; plasma membrane; axonogenesis; lateral plasma membrane;
CRYAB	7	negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; cytosol; plasma membrane; microtubule binding;
SNCA	7	negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; cytosol; plasma membrane; microtubule binding;
HOOK3	6	microtubule cytoskeleton organization; cytoplasmic microtubule organization; protein binding; centrosome; cytoplasm; microtubule binding;
KIF23	6	microtubule cytoskeleton organization; nucleus; protein binding; centrosome; cytosol; microtubule binding;
MAP1S	6	microtubule cytoskeleton organization; nucleus; protein binding; apoptotic process; cytosol; microtubule binding;
PPP4C	6	microtubule cytoskeleton organization; nucleus; protein binding; centrosome; cytoplasm; plasma membrane;
SMC1A	6	microtubule cytoskeleton organization; nucleus; protein binding; cytoplasm; kinetochore; mitotic metaphase/anaphase transition;
TPPP	6	microtubule cytoskeleton organization; nucleus; protein binding; cytoplasm; plasma membrane; microtubule binding;
UXT	6	microtubule cytoskeleton organization; nucleus; protein binding; centrosome; cytoplasm; microtubule binding;
GSN	6	regulation of cytoskeleton organization; lamellipodium; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; cytosol;
LATS1	6	regulation of cytoskeleton organization; negative regulation of canonical Wnt receptor signaling pathway; protein kinase binding; negative regulation of cyclin-dependent protein kinase activity; protein binding; cytosol;
MAPK3	6	regulation of cytoskeleton organization; nucleus; protein binding; apoptotic process; cytosol; response to DNA damage stimulus;
NCK2	6	regulation of cytoskeleton organization; protein binding; cytoplasm; cytosol; cell migration; negative regulation of cell proliferation;
BCL9	6	canonical Wnt receptor signaling pathway; somatic stem cell maintenance; nucleus; protein binding; cytoplasm; beta-catenin binding;
WNT10A	6	canonical Wnt receptor signaling pathway; skin development; hair follicle development; plasma membrane; axis specification; anterior/posterior pattern specification;
DAB2	6	negative regulation of canonical Wnt receptor signaling pathway; positive regulation of cell migration; negative regulation of apoptotic process; nucleus; protein binding; apoptotic process;
ARL2	6	tight junction assembly; positive regulation of microtubule polymerization; nucleus; protein binding; centrosome; lateral plasma membrane;
CAV3	6	cytoplasmic microtubule organization; positive regulation of microtubule polymerization; negative regulation of MAPK cascade; muscle cell homeostasis; protein binding; plasma membrane;
CORO1A	6	positive regulation of cell migration; lamellipodium; nucleus; protein binding; cytoplasm; plasma membrane;
PIK3R1	6	positive regulation of cell migration; positive regulation of apoptotic process; negative regulation of apoptotic process; protein binding; cytosol; plasma membrane;
TRIM32	6	positive regulation of cell migration; negative regulation of apoptotic process; positive regulation of protein catabolic process; nucleus; protein binding; cytoplasm;
SPATA13	6	lamellipodium; ruffle membrane; nucleus; protein binding; cytoplasm; cell migration;
WASL	6	lamellipodium; nucleus; protein binding; protein complex assembly; cytosol; plasma membrane;
AKAP7	6	protein kinase binding; nucleus; protein binding; cytosol; plasma membrane; lateral plasma membrane;
PAK1	6	protein kinase binding; protein binding; cytoplasm; apoptotic process; cytosol; plasma membrane;
RAD9A	6	protein kinase binding; positive regulation of apoptotic process; nucleus; protein binding; cytoplasm; response to DNA damage stimulus;
ATM	6	positive regulation of apoptotic process; negative regulation of apoptotic process; protein binding; mitotic cell cycle spindle assembly checkpoint; response to DNA damage stimulus; cell cycle arrest;
FLCN	6	positive regulation of apoptotic process; positive regulation of cell adhesion; nucleus; protein binding; cytoplasm; plasma membrane;
ZBTB16	6	positive regulation of apoptotic process; nucleus; protein binding; apoptotic process; negative regulation of cell proliferation; anterior/posterior pattern specification;
FGF10	6	somatic stem cell maintenance; negative regulation of apoptotic process; thymus development; nucleus; plasma membrane; negative regulation of cell proliferation;
DSG1	6	gamma-catenin binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; cytosol; plasma membrane; lateral plasma membrane;
BIRC2	6	negative regulation of apoptotic process; nucleus; protein binding; cellular component disassembly involved in execution phase of apoptosis; apoptotic process; cytosol;
CBL	6	negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; cytosol; plasma membrane;
GSTP1	6	negative regulation of apoptotic process; negative regulation of MAPK cascade; nucleus; protein binding; cytoplasm; cytosol;
MALT1	6	negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; cytosol; plasma membrane;
BAIAP2	6	nucleus; protein binding; cytoplasm; cytosol; plasma membrane; axonogenesis;
CEP57	6	nucleus; protein binding; centrosome; cytoplasm; cytosol; microtubule binding;
CUL5	6	nucleus; protein binding; cytosol; plasma membrane; cell cycle arrest; negative regulation of cell proliferation;
DAXX	6	nucleus; protein binding; cytoplasm; cytokinesis after mitosis; apoptotic process; cytosol;
EGLN3	6	nucleus; protein binding; cytoplasm; apoptotic process; cytosol; response to DNA damage stimulus;
LPXN	6	nucleus; protein binding; cytoplasm; protein complex assembly; plasma membrane; cell adhesion;
MAGI2	6	nucleus; protein binding; cytoplasm; tight junction; plasma membrane; negative regulation of cell proliferation;
PRKCB	6	nucleus; protein binding; cytoplasm; apoptotic process; cytosol; plasma membrane;
PRKD1	6	nucleus; protein binding; cytoplasm; apoptotic process; cytosol; plasma membrane;
CENPJ	5	microtubule cytoskeleton organization; protein kinase binding; protein binding; centrosome; cytosol;
CKAP5	5	microtubule cytoskeleton organization; microtubule plus end; protein binding; centrosome; cytosol;
KIF11	5	microtubule cytoskeleton organization; protein kinase binding; cytoplasm; cytosol; microtubule binding;
MID1IP1	5	microtubule cytoskeleton organization; regulation of cytoskeleton organization; nucleus; cytosol; negative regulation of microtubule depolymerization;
NUSAP1	5	microtubule cytoskeleton organization; nucleus; cytoplasm; cytokinesis after mitosis; microtubule binding;
SMC3	5	microtubule cytoskeleton organization; nucleus; protein binding; cytoplasm; mitotic metaphase/anaphase transition;
TUBG1	5	microtubule cytoskeleton organization; protein binding; centrosome; cytoplasm; cytosol;
ARF6	5	regulation of cytoskeleton organization; protein binding; apoptotic process; plasma membrane; cell adhesion;
CDC42EP2	5	regulation of cytoskeleton organization; positive regulation of pseudopodium assembly; protein binding; cytoplasm; plasma membrane;
CEP250	5	regulation of cytoskeleton organization; protein kinase binding; protein binding; centrosome; cytosol;
CRIPAK	5	regulation of cytoskeleton organization; nucleus; protein binding; cytoplasm; plasma membrane;
SORBS3	5	regulation of cytoskeleton organization; nucleus; protein binding; cytosol; cell adhesion;
ACHE	5	retina development in camera-type eye; nucleus; protein binding; plasma membrane; cell adhesion;
PVRL1	5	retina development in camera-type eye; protein binding; cell-cell adherens junction; plasma membrane; cell adhesion;
DAB2IP	5	negative regulation of canonical Wnt receptor signaling pathway; protein kinase binding; positive regulation of apoptotic process; cytoplasm; plasma membrane;
INVS	5	negative regulation of canonical Wnt receptor signaling pathway; nucleus; protein binding; cytoplasm; kidney development;
LATS2	5	negative regulation of canonical Wnt receptor signaling pathway; negative regulation of cyclin-dependent protein kinase activity; nucleus; protein binding; cytosol;
PSRC1	5	positive regulation of microtubule polymerization; protein binding; cytoplasm; cytosol; microtubule binding;
ADRA2A	5	positive regulation of cell migration; protein kinase binding; protein binding; cytoplasm; plasma membrane;
CDH13	5	positive regulation of cell migration; cadherin binding; cytoplasm; plasma membrane; negative regulation of cell proliferation;
SEMA4D	5	positive regulation of cell migration; negative regulation of apoptotic process; protein binding; plasma membrane; cell adhesion;
VIL1	5	positive regulation of cell migration; lamellipodium; protein binding; cytoplasm; protein complex assembly;
AMOTL1	5	lamellipodium; protein binding; cytoplasm; tight junction; cytosol;
BAD	5	protein kinase binding; positive regulation of apoptotic process; protein binding; apoptotic process; cytosol;
GATA6	5	protein kinase binding; negative regulation of apoptotic process; nucleus; protein binding; apoptotic process;
LLGL1	5	protein kinase binding; protein binding; cytoplasm; protein complex assembly; axonogenesis;
NEK6	5	protein kinase binding; nucleus; protein binding; cytoplasm; apoptotic process;
PARK2	5	protein kinase binding; nucleus; protein binding; cytoplasm; cytosol;
RPTOR	5	protein kinase binding; protein binding; cytoplasm; cytosol; cell cycle arrest;
FOSL1	5	positive regulation of apoptotic process; nucleus; protein binding; cytosol; negative regulation of cell proliferation;
HOXA5	5	positive regulation of apoptotic process; nucleus; protein binding; cell migration; anterior/posterior pattern specification;
PYCARD	5	positive regulation of apoptotic process; nucleus; protein binding; cytoplasm; cytosol;
ERBB2	5	regulation of microtubule-based process; positive regulation of cell adhesion; nucleus; protein binding; plasma membrane;
CFL1	5	ruffle membrane; negative regulation of apoptotic process; nucleus; protein binding; cytoplasm;
BIRC3	5	negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; apoptotic process;
BNIP3	5	negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; apoptotic process;
FLT4	5	negative regulation of apoptotic process; nucleus; protein binding; cytoplasm; plasma membrane;
HNF1B	5	negative regulation of apoptotic process; nucleus; protein binding; kidney development; anterior/posterior pattern specification;
IL1RN	5	negative regulation of apoptotic process; nucleus; centrosome; cytoplasm; plasma membrane;
MAPK7	5	negative regulation of apoptotic process; nucleus; protein binding; apoptotic process; cytosol;
PDCD10	5	negative regulation of apoptotic process; protein binding; apoptotic process; cytosol; plasma membrane;
PIK3CG	5	negative regulation of apoptotic process; protein binding; cytoplasm; cytosol; plasma membrane;
PRKAA1	5	negative regulation of apoptotic process; nucleus; protein binding; cytosol; cell cycle arrest;
PTTG1	5	chromosome organization; nucleus; protein binding; cytoplasm; cytosol;
IL12B	5	positive regulation of cell adhesion; protein binding; cytoplasm; cell cycle arrest; cell migration;
GJA1	5	positive regulation of protein catabolic process; protein binding; apoptotic process; plasma membrane; negative regulation of cell proliferation;
ADRB1	5	nucleus; protein binding; cytoplasm; apoptotic process; plasma membrane;
AIP	5	nucleus; protein binding; cytoplasm; cytosol; plasma membrane;
ALKBH8	5	nucleus; protein binding; cytoplasm; cytosol; response to DNA damage stimulus;
ARRB1	5	nucleus; protein binding; cytoplasm; cytosol; plasma membrane;
ARRB2	5	nucleus; protein binding; cytoplasm; cytosol; plasma membrane;
ARVCF	5	nucleus; protein binding; cytoplasm; plasma membrane; cell adhesion;
CEP164	5	nucleus; protein binding; centrosome; cytoplasm; cytosol;
CHD1L	5	nucleus; protein binding; cytoplasm; plasma membrane; response to DNA damage stimulus;
CHEK1	5	nucleus; protein binding; centrosome; cytosol; response to DNA damage stimulus;
FANCC	5	nucleus; protein binding; cytoplasm; protein complex assembly; cytosol;
FRK	5	nucleus; protein binding; cytoplasm; plasma membrane; negative regulation of cell proliferation;
GZMB	5	nucleus; protein binding; cytoplasm; apoptotic process; cytosol;
HMGA1	5	nucleus; protein binding; protein complex assembly; cytosol; negative regulation of cell proliferation;
HOXA9	5	nucleus; protein binding; cytoplasm; proximal/distal pattern formation; anterior/posterior pattern specification;
IRF7	5	nucleus; protein binding; cytoplasm; cytosol; response to DNA damage stimulus;
PDCD4	5	nucleus; protein binding; cytoplasm; apoptotic process; cytosol;
PDE2A	5	nucleus; protein binding; cytoplasm; cytosol; plasma membrane;
PERP	5	nucleus; cytoplasm; apoptotic process; plasma membrane; cell adhesion;
PSMC3	5	nucleus; protein binding; cytoplasm; apoptotic process; cytosol;
RFWD2	5	nucleus; protein binding; centrosome; cytoplasm; cytosol;
ROCK2	5	nucleus; protein binding; centrosome; cytosol; plasma membrane;
SART1	5	nucleus; protein binding; cytoplasm; cytosol; cell cycle arrest;
STXBP3	5	nucleus; protein binding; cytoplasm; cytosol; plasma membrane;
TAOK2	5	nucleus; cytoplasm; apoptotic process; response to DNA damage stimulus; cell migration;
WWP1	5	nucleus; protein binding; cytoplasm; cytosol; plasma membrane;
ZW10	5	nucleus; protein binding; kinetochore; protein complex assembly; cytosol;
DRD2	5	protein binding; plasma membrane; axonogenesis; lateral plasma membrane; negative regulation of cell proliferation;
FEZ1	5	protein binding; centrosome; cytoplasm; plasma membrane; cell adhesion;
NDE1	5	protein binding; centrosome; kinetochore; cytosol; microtubule binding;

Genes shared at least 2 KEGG pathways with APC (count: 29)

Gene Symbol	Pathway Count	Pathway List
GSK3B	5	Colorectal cancer; Endometrial cancer; Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer;
CCND1	4	Colorectal cancer; Endometrial cancer; Wnt signaling pathway; Pathways in cancer;
MAPK1	4	Colorectal cancer; Endometrial cancer; Regulation of actin cytoskeleton; Pathways in cancer;
MAPK3	4	Colorectal cancer; Endometrial cancer; Regulation of actin cytoskeleton; Pathways in cancer;
PIK3CG	4	Colorectal cancer; Endometrial cancer; Regulation of actin cytoskeleton; Pathways in cancer;
PIK3R1	4	Colorectal cancer; Endometrial cancer; Regulation of actin cytoskeleton; Pathways in cancer;
BAD	3	Colorectal cancer; Endometrial cancer; Pathways in cancer;
MAPK9	3	Colorectal cancer; Wnt signaling pathway; Pathways in cancer;
FZD4	3	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer;
WNT10A	3	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer;
WNT11	3	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer;
WNT6	3	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer;
CYCS	2	Colorectal cancer; Pathways in cancer;
TGFBR1	2	Colorectal cancer; Pathways in cancer;
CTNNA2	2	Endometrial cancer; Pathways in cancer;
CTNNA3	2	Endometrial cancer; Pathways in cancer;
ERBB2	2	Endometrial cancer; Pathways in cancer;
PTCH1	2	Basal cell carcinoma; Pathways in cancer;
STK36	2	Basal cell carcinoma; Pathways in cancer;
CRKL	2	Regulation of actin cytoskeleton; Pathways in cancer;
FGF10	2	Regulation of actin cytoskeleton; Pathways in cancer;
FGF19	2	Regulation of actin cytoskeleton; Pathways in cancer;
FGF3	2	Regulation of actin cytoskeleton; Pathways in cancer;
FGF4	2	Regulation of actin cytoskeleton; Pathways in cancer;
FGF9	2	Regulation of actin cytoskeleton; Pathways in cancer;
FN1	2	Regulation of actin cytoskeleton; Pathways in cancer;
ITGA2	2	Regulation of actin cytoskeleton; Pathways in cancer;
ROCK2	2	Regulation of actin cytoskeleton; Wnt signaling pathway;
PRKCB	2	Wnt signaling pathway; Pathways in cancer;

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Region: chr5:112043195..112203279 View in gBrowse