ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	APOC2
Approved Name	apolipoprotein C-II
Location	19q13.2
Position	chr19:45449243-45452818, +
External Links	HGNC: 609 Entrez Gene: 344 Ensembl: ENSG00000234906 UCSC: uc002pah.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 39)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49
GO:0004091	carboxylesterase activity	Molecular Function		40

GO terms by database search (count: 37)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0070328	triglyceride homeostasis	Biological Process	IMP[17018885]	7
GO:0051006	positive regulation of lipoprotein lipase activity	Biological Process	IDA[15878877]	3
GO:0055102	lipase inhibitor activity	Molecular Function	IDA[182536]	3
GO:0060230	lipoprotein lipase activator activity	Molecular Function	IDA[10727238]	2
GO:0060697	positive regulation of phospholipid catabolic process	Biological Process	IDA[10727238]	1
GO:0034384	high-density lipoprotein particle clearance	Biological Process	IMP[15778093]	3
GO:0034382	chylomicron remnant clearance	Biological Process	IDA[4020294]	2
GO:0042627	chylomicron	Cellular Component	IDA[8245722]	5
GO:0042157	lipoprotein metabolic process	Biological Process		11
GO:0034370	triglyceride-rich lipoprotein particle remodeling	Biological Process	TAS[17018885]	2
GO:0034366	spherical high-density lipoprotein particle	Cellular Component	IDA[16682745]	3
GO:0034372	very-low-density lipoprotein particle remodeling	Biological Process	TAS[15778093]	3
GO:0034371	chylomicron remodeling	Biological Process	IC[10727238]	3
GO:0045723	positive regulation of fatty acid biosynthetic process	Biological Process	IDA[10727238]	4
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0048261	negative regulation of receptor-mediated endocytosis	Biological Process	IDA[1917954]	4
GO:0045833	negative regulation of lipid metabolic process	Biological Process	IDA[182536]	2
GO:0042803	protein homodimerization activity	Molecular Function	IMP[8245722]	113
GO:0042632	cholesterol homeostasis	Biological Process	IC[15778093]	18
GO:0043691	reverse cholesterol transport	Biological Process	IC[15778093]	7
GO:0043274	phospholipase binding	Molecular Function	IPI[10727238]	3
GO:0010916	negative regulation of very-low-density lipoprotein particle clearance	Biological Process	IDA[1917954]	2
GO:0016004	phospholipase activator activity	Molecular Function	IDA[10727238]	1
GO:0010898	positive regulation of triglyceride catabolic process	Biological Process	IDA[10727238]	4
GO:0010902	positive regulation of very-low-density lipoprotein particle remodeling	Biological Process	IC[10727238]	2
GO:0008289	lipid binding	Molecular Function	IDA[10727238]	23
GO:0010518	positive regulation of phospholipase activity	Biological Process	IDA[10727238]	1
GO:0005615	extracellular space	Cellular Component	IDA[10727238]	126
GO:0006629	lipid metabolic process	Biological Process		51
GO:0034362	low-density lipoprotein particle	Cellular Component	IDA[8245722]	3
GO:0034363	intermediate-density lipoprotein particle	Cellular Component	IDA[17336988]	2
GO:0033700	phospholipid efflux	Biological Process	IDA[11162594]	5
GO:0034361	very-low-density lipoprotein particle	Cellular Component	IDA[8245722]	6
GO:0032375	negative regulation of cholesterol transport	Biological Process	IMP[15778093]	1
GO:0033344	cholesterol efflux	Biological Process	IDA[11162594]	8
GO:0016042	lipid catabolic process	Biological Process		32
GO:0005576	extracellular region	Cellular Component	NAS[14718574]	240

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with APOC2 (count: 23)

Gene Symbol	Pathway Count	Pathway List
APOC3	19	triglyceride homeostasis; lipase inhibitor activity; chylomicron remnant clearance; chylomicron; lipoprotein metabolic process; spherical high-density lipoprotein particle; small molecule metabolic process; negative regulation of receptor-mediated endocytosis; negative regulation of lipid metabolic process; cholesterol homeostasis; reverse cholesterol transport; negative regulation of very-low-density lipoprotein particle clearance; extracellular space; lipid metabolic process; intermediate-density lipoprotein particle; phospholipid efflux; very-low-density lipoprotein particle; cholesterol efflux; extracellular region;
APOA4	18	positive regulation of lipoprotein lipase activity; chylomicron; lipoprotein metabolic process; very-low-density lipoprotein particle remodeling; chylomicron remodeling; positive regulation of fatty acid biosynthetic process; small molecule metabolic process; protein homodimerization activity; cholesterol homeostasis; reverse cholesterol transport; positive regulation of triglyceride catabolic process; lipid binding; extracellular space; lipid metabolic process; phospholipid efflux; very-low-density lipoprotein particle; cholesterol efflux; extracellular region;
APOA5	16	triglyceride homeostasis; positive regulation of lipoprotein lipase activity; lipoprotein lipase activator activity; chylomicron; lipoprotein metabolic process; triglyceride-rich lipoprotein particle remodeling; positive regulation of fatty acid biosynthetic process; small molecule metabolic process; cholesterol homeostasis; positive regulation of triglyceride catabolic process; positive regulation of very-low-density lipoprotein particle remodeling; lipid binding; extracellular space; low-density lipoprotein particle; very-low-density lipoprotein particle; extracellular region;
APOA1	14	triglyceride homeostasis; lipase inhibitor activity; high-density lipoprotein particle clearance; lipoprotein metabolic process; spherical high-density lipoprotein particle; small molecule metabolic process; cholesterol homeostasis; reverse cholesterol transport; extracellular space; lipid metabolic process; phospholipid efflux; very-low-density lipoprotein particle; cholesterol efflux; extracellular region;
LPL	12	triglyceride homeostasis; chylomicron; lipoprotein metabolic process; very-low-density lipoprotein particle remodeling; chylomicron remodeling; small molecule metabolic process; extracellular space; lipid metabolic process; very-low-density lipoprotein particle; lipase activity; extracellular region; carboxylesterase activity;
SCARB1	9	triglyceride homeostasis; high-density lipoprotein particle clearance; lipoprotein metabolic process; small molecule metabolic process; protein homodimerization activity; cholesterol homeostasis; reverse cholesterol transport; lipid metabolic process; cholesterol efflux;
ABCA1	7	lipoprotein metabolic process; small molecule metabolic process; cholesterol homeostasis; reverse cholesterol transport; lipid metabolic process; phospholipid efflux; cholesterol efflux;
MGLL	6	small molecule metabolic process; protein homodimerization activity; lipid binding; lipid metabolic process; lipase activity; carboxylesterase activity;
PLA2G10	6	small molecule metabolic process; cholesterol homeostasis; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;
PLA2G2A	6	small molecule metabolic process; extracellular space; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;
PLA2G3	6	small molecule metabolic process; extracellular space; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;
PNLIP	6	small molecule metabolic process; lipid metabolic process; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;
PNLIPRP2	6	small molecule metabolic process; extracellular space; lipid metabolic process; lipase activity; extracellular region; carboxylesterase activity;
LIPG	6	cholesterol homeostasis; reverse cholesterol transport; extracellular space; lipid metabolic process; lipase activity; carboxylesterase activity;
ACHE	5	small molecule metabolic process; protein homodimerization activity; extracellular space; extracellular region; carboxylesterase activity;
LIPE	5	small molecule metabolic process; lipid metabolic process; lipid catabolic process; lipase activity; carboxylesterase activity;
PLA2G1B	5	small molecule metabolic process; extracellular space; lipase activity; extracellular region; carboxylesterase activity;
PLA2G2D	5	small molecule metabolic process; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;
PLA2G2E	5	small molecule metabolic process; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;
PLA2G5	5	small molecule metabolic process; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;
LIPF	5	lipid binding; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;
PNLIPRP1	5	extracellular space; lipid metabolic process; lipase activity; extracellular region; carboxylesterase activity;
PLA1A	5	lipid metabolic process; lipid catabolic process; lipase activity; extracellular region; carboxylesterase activity;

Genes shared at least 2 KEGG pathways with APOC2 (count: 0)

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Region: chr19:45449243..45452818 View in gBrowse