ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ARF6
Approved Name	ADP-ribosylation factor 6
Location	14q21.3
Position	chr14:50359736-50363772, +
External Links	HGNC: 659 Entrez Gene: 382 Ensembl: ENSG00000165527 UCSC: uc001wxg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 33)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051493	regulation of cytoskeleton organization	Biological Process		32

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010008	endosome membrane	Cellular Component		27
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0016020	membrane	Cellular Component	TAS[8702973]	139
GO:0015031	protein transport	Biological Process		75
GO:0006915	apoptotic process	Biological Process		111
GO:0006184	GTP catabolic process	Biological Process	TAS[1993656]	22
GO:0007155	cell adhesion	Biological Process	TAS[10036235]	86
GO:0006928	cellular component movement	Biological Process	TAS[10036235]	16
GO:0031996	thioesterase binding	Molecular Function	IPI[15509780]	3
GO:0031529	ruffle organization	Biological Process	IDA[10036235]	5
GO:0035020	regulation of Rac protein signal transduction	Biological Process	IDA[10036235]	1
GO:0034394	protein localization to cell surface	Biological Process		4
GO:0030838	positive regulation of actin filament polymerization	Biological Process	IMP[10036235]	9
GO:0016192	vesicle-mediated transport	Biological Process	TAS[10913182]	28
GO:0031527	filopodium membrane	Cellular Component	IDA[14978216]	2
GO:0030866	cortical actin cytoskeleton organization	Biological Process	IMP[10913182]	3
GO:0001726	ruffle	Cellular Component	IDA[9312003]	14
GO:0001889	liver development	Biological Process		14
GO:0005769	early endosome	Cellular Component		25
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005886	plasma membrane	Cellular Component	IDA[17398095]	772
GO:0005938	cell cortex	Cellular Component	IDA[10913182]	26
GO:0003924	GTPase activity	Molecular Function	TAS[1993656]	41
GO:0005515	protein binding	Molecular Function	IPI[16415858]	910
GO:0005525	GTP binding	Molecular Function	TAS[10913182]	53
GO:0005768	endosome	Cellular Component	TAS[10913182]	27
GO:0090162	establishment of epithelial cell polarity	Biological Process		1
GO:0060998	regulation of dendritic spine development	Biological Process		1
GO:0090004	positive regulation of establishment of protein localization to plasma membrane	Biological Process		3
GO:0055037	recycling endosome	Cellular Component		4
GO:0048261	negative regulation of receptor-mediated endocytosis	Biological Process	TAS[9312003]	4
GO:0051489	regulation of filopodium assembly	Biological Process	IDA[14978216]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa04666	Fc gamma R-mediated phagocytosis	28	Phagocytosis plays an essential role in host-defense mechani...... Phagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes take part in this process in higher organisms. After opsonization with antibodies (IgG), foreign extracellular materials are recognized by Fc gamma receptors. Cross-linking of Fc gamma receptors initiates a variety of signals mediated by tyrosine phosphorylation of multiple proteins, which lead through the actin cytoskeleton rearrangements and membrane remodeling to the formation of phagosomes. Nascent phagosomes undergo a process of maturation that involves fusion with lysosomes. The acquisition of lysosomal proteases and release of reactive oxygen species are crucial for digestion of engulfed materials in phagosomes. More...

Genes shared at least 5 GO terms with ARF6 (count: 36)

Gene Symbol	Pathway Count	Pathway List
RAB14	10	small GTPase mediated signal transduction; protein transport; GTP catabolic process; vesicle-mediated transport; early endosome; plasma membrane; GTPase activity; protein binding; GTP binding; recycling endosome;
ARFIP2	8	small GTPase mediated signal transduction; cellular component movement; ruffle organization; ruffle; plasma membrane; cell cortex; protein binding; GTP binding;
RAB6A	7	small GTPase mediated signal transduction; membrane; GTP catabolic process; Golgi apparatus; GTPase activity; protein binding; GTP binding;
ARHGAP5	6	small GTPase mediated signal transduction; membrane; GTP catabolic process; cell adhesion; GTPase activity; GTP binding;
MAPK1	6	small GTPase mediated signal transduction; apoptotic process; early endosome; Golgi apparatus; protein binding; regulation of cytoskeleton organization;
MAPK3	6	small GTPase mediated signal transduction; apoptotic process; early endosome; Golgi apparatus; protein binding; regulation of cytoskeleton organization;
RAB30	6	small GTPase mediated signal transduction; membrane; protein transport; GTP catabolic process; GTPase activity; GTP binding;
RAB38	6	small GTPase mediated signal transduction; protein transport; GTP catabolic process; plasma membrane; GTPase activity; GTP binding;
ARPC2	6	cellular component movement; positive regulation of actin filament polymerization; Golgi apparatus; plasma membrane; protein binding; endosome;
ARHGAP32	5	endosome membrane; small GTPase mediated signal transduction; plasma membrane; cell cortex; protein binding;
CHMP1A	5	endosome membrane; protein transport; vesicle-mediated transport; early endosome; protein binding;
EHD1	5	endosome membrane; plasma membrane; GTPase activity; protein binding; GTP binding;
EHD3	5	endosome membrane; plasma membrane; GTPase activity; protein binding; GTP binding;
SORT1	5	endosome membrane; early endosome; Golgi apparatus; plasma membrane; endosome;
ARHGEF2	5	small GTPase mediated signal transduction; apoptotic process; Golgi apparatus; protein binding; regulation of cytoskeleton organization;
ARL17B	5	small GTPase mediated signal transduction; protein transport; vesicle-mediated transport; Golgi apparatus; GTP binding;
ARL2	5	small GTPase mediated signal transduction; GTP catabolic process; GTPase activity; protein binding; GTP binding;
RAB1B	5	small GTPase mediated signal transduction; membrane; protein transport; Golgi apparatus; GTP binding;
RAB27A	5	small GTPase mediated signal transduction; Golgi apparatus; GTPase activity; protein binding; GTP binding;
RAB2A	5	small GTPase mediated signal transduction; protein transport; GTP catabolic process; GTPase activity; GTP binding;
RAB6C	5	small GTPase mediated signal transduction; protein transport; GTP catabolic process; GTPase activity; GTP binding;
RHOD	5	small GTPase mediated signal transduction; GTP catabolic process; plasma membrane; GTPase activity; GTP binding;
ACHE	5	membrane; cell adhesion; Golgi apparatus; plasma membrane; protein binding;
BIRC6	5	membrane; apoptotic process; Golgi apparatus; protein binding; endosome;
CDC42EP2	5	membrane; positive regulation of actin filament polymerization; plasma membrane; protein binding; regulation of cytoskeleton organization;
GOPC	5	membrane; protein transport; Golgi apparatus; plasma membrane; protein binding;
SYTL2	5	membrane; vesicle-mediated transport; Golgi apparatus; plasma membrane; protein binding;
APC	5	apoptotic process; cell adhesion; plasma membrane; protein binding; regulation of cytoskeleton organization;
GJA1	5	apoptotic process; early endosome; Golgi apparatus; plasma membrane; protein binding;
GSN	5	apoptotic process; vesicle-mediated transport; ruffle; protein binding; regulation of cytoskeleton organization;
OPA1	5	apoptotic process; GTP catabolic process; GTPase activity; protein binding; GTP binding;
PAK1	5	apoptotic process; ruffle; Golgi apparatus; plasma membrane; protein binding;
PRKD1	5	apoptotic process; Golgi apparatus; plasma membrane; cell cortex; protein binding;
SEPT5	5	GTP catabolic process; plasma membrane; GTPase activity; protein binding; GTP binding;
NF2	5	filopodium membrane; early endosome; plasma membrane; protein binding; regulation of cytoskeleton organization;
CLASP2	5	Golgi apparatus; plasma membrane; cell cortex; protein binding; regulation of cytoskeleton organization;

Genes shared at least 2 KEGG pathways with ARF6 (count: 4)

Gene Symbol	Pathway Count	Pathway List
ASAP2	2	Endocytosis; Fc gamma R-mediated phagocytosis;
DNM1	2	Endocytosis; Fc gamma R-mediated phagocytosis;
PLD1	2	Endocytosis; Fc gamma R-mediated phagocytosis;
PLD2	2	Endocytosis; Fc gamma R-mediated phagocytosis;

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Region: chr14:50359736..50363772 View in gBrowse