ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	BARD1
Approved Name	BRCA1 associated RING domain 1
Location	2q34-q35
Position	chr2:215590370-215674428, -
External Links	HGNC: 952 Entrez Gene: 580 Ensembl: ENSG00000138376 UCSC: uc002veu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[15383276]	910
GO:0005634	nucleus	Cellular Component	IDA[15265711]; IMP[15632137]	770
GO:0003723	RNA binding	Molecular Function	IDA[12419249]	104
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	NAS[15905410]	52
GO:0006974	response to DNA damage stimulus	Biological Process	NAS[15905410]	37
GO:0007050	cell cycle arrest	Biological Process	NAS[15632137]	25
GO:0005737	cytoplasm	Cellular Component	IDA[15265711]	690
GO:0006281	DNA repair	Biological Process		62
GO:0019900	kinase binding	Molecular Function	NAS[15782130]	7
GO:0031436	BRCA1-BARD1 complex	Cellular Component	IDA[19117993]	1
GO:0008270	zinc ion binding	Molecular Function		323
GO:0016567	protein ubiquitination	Biological Process	NAS[15905410]	41
GO:0042803	protein homodimerization activity	Molecular Function	IPI[15265711]	113
GO:0043065	positive regulation of apoptotic process	Biological Process	IMP[15782130]	34
GO:0031441	negative regulation of mRNA 3'-end processing	Biological Process	NAS[15905410]	1
GO:0042325	regulation of phosphorylation	Biological Process	IMP[15782130]	3
GO:0085020	protein K6-linked ubiquitination	Biological Process	IDA[12890688]	1
GO:0070531	BRCA1-A complex	Cellular Component	IDA[19261749]	1
GO:0045732	positive regulation of protein catabolic process	Biological Process	NAS[15905410]	8
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP[15265711]	77
GO:0046982	protein heterodimerization activity	Molecular Function	IPI[15265711]	68
GO:0046826	negative regulation of protein export from nucleus	Biological Process	IDA[15265711]	2
GO:0001894	tissue homeostasis	Biological Process	TAS[15782130]	6
GO:0000151	ubiquitin ligase complex	Cellular Component	NAS[14976165]	15

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with BARD1 (count: 61)

Gene Symbol	Pathway Count	Pathway List
TRIM32	9	protein binding; nucleus; RNA binding; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; protein ubiquitination; positive regulation of protein catabolic process; negative regulation of apoptotic process;
APC	8	protein binding; nucleus; response to DNA damage stimulus; cell cycle arrest; cytoplasm; positive regulation of apoptotic process; positive regulation of protein catabolic process; negative regulation of apoptotic process;
HERC2	8	protein binding; nucleus; ubiquitin-protein ligase activity; response to DNA damage stimulus; cytoplasm; DNA repair; zinc ion binding; protein ubiquitination;
RCHY1	8	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; protein ubiquitination; protein homodimerization activity; ubiquitin ligase complex;
TNFAIP3	8	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; kinase binding; zinc ion binding; positive regulation of protein catabolic process; negative regulation of apoptotic process;
CBL	7	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; protein ubiquitination; negative regulation of apoptotic process;
MEN1	7	protein binding; nucleus; response to DNA damage stimulus; cell cycle arrest; cytoplasm; DNA repair; positive regulation of apoptotic process;
RNF40	7	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; protein homodimerization activity; ubiquitin ligase complex;
TRIP12	7	protein binding; nucleus; ubiquitin-protein ligase activity; response to DNA damage stimulus; cytoplasm; DNA repair; protein ubiquitination;
APBB1	6	protein binding; nucleus; response to DNA damage stimulus; cell cycle arrest; cytoplasm; positive regulation of apoptotic process;
ATM	6	protein binding; response to DNA damage stimulus; cell cycle arrest; DNA repair; positive regulation of apoptotic process; negative regulation of apoptotic process;
BIRC3	6	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; negative regulation of apoptotic process;
BNIP3	6	protein binding; nucleus; cytoplasm; protein homodimerization activity; negative regulation of apoptotic process; protein heterodimerization activity;
FBXO4	6	protein binding; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination; protein homodimerization activity; ubiquitin ligase complex;
IGHMBP2	6	protein binding; nucleus; RNA binding; cytoplasm; DNA repair; zinc ion binding;
KLHL20	6	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination; negative regulation of apoptotic process;
MALT1	6	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination; negative regulation of apoptotic process;
PARK2	6	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; kinase binding; zinc ion binding;
PRPF19	6	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; DNA repair; ubiquitin ligase complex;
RAD9A	6	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; DNA repair; positive regulation of apoptotic process;
TRIM5	6	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; protein homodimerization activity;
WWP1	6	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination; ubiquitin ligase complex;
ZBTB16	6	protein binding; nucleus; zinc ion binding; protein ubiquitination; protein homodimerization activity; positive regulation of apoptotic process;
RFWD3	6	nucleus; ubiquitin-protein ligase activity; cytoplasm; DNA repair; zinc ion binding; protein ubiquitination;
AATF	5	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; negative regulation of apoptotic process;
ALKBH8	5	protein binding; nucleus; RNA binding; response to DNA damage stimulus; cytoplasm;
BIRC2	5	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; negative regulation of apoptotic process;
BRAP	5	protein binding; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; ubiquitin ligase complex;
CHD1L	5	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; DNA repair;
CRYAB	5	protein binding; nucleus; cytoplasm; protein homodimerization activity; negative regulation of apoptotic process;
ERCC8	5	protein binding; nucleus; ubiquitin-protein ligase activity; response to DNA damage stimulus; DNA repair;
FBXO25	5	protein binding; nucleus; ubiquitin-protein ligase activity; protein ubiquitination; ubiquitin ligase complex;
FBXO7	5	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; ubiquitin ligase complex;
FUS	5	protein binding; nucleus; RNA binding; cytoplasm; zinc ion binding;
GSK3B	5	protein binding; nucleus; cytoplasm; positive regulation of protein catabolic process; negative regulation of apoptotic process;
H2AFX	5	protein binding; nucleus; response to DNA damage stimulus; DNA repair; protein heterodimerization activity;
HNF1B	5	protein binding; nucleus; protein homodimerization activity; negative regulation of apoptotic process; protein heterodimerization activity;
IL12B	5	protein binding; cell cycle arrest; cytoplasm; protein homodimerization activity; protein heterodimerization activity;
MMS19	5	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; DNA repair;
NEDD4L	5	protein binding; nucleus; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination;
NR4A2	5	protein binding; nucleus; cytoplasm; zinc ion binding; protein heterodimerization activity;
PRKAA1	5	protein binding; nucleus; cell cycle arrest; kinase binding; negative regulation of apoptotic process;
PYCARD	5	protein binding; nucleus; cytoplasm; protein homodimerization activity; positive regulation of apoptotic process;
RBM4	5	protein binding; nucleus; RNA binding; cytoplasm; zinc ion binding;
RFWD2	5	protein binding; nucleus; cytoplasm; zinc ion binding; protein ubiquitination;
RNF144B	5	protein binding; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; ubiquitin ligase complex;
RNF2	5	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; ubiquitin ligase complex;
RNF20	5	protein binding; nucleus; ubiquitin-protein ligase activity; zinc ion binding; ubiquitin ligase complex;
SMC1A	5	protein binding; nucleus; cytoplasm; DNA repair; protein heterodimerization activity;
SMC2	5	protein binding; nucleus; cytoplasm; DNA repair; protein heterodimerization activity;
SMC3	5	protein binding; nucleus; cytoplasm; DNA repair; protein heterodimerization activity;
SNCA	5	protein binding; nucleus; cytoplasm; zinc ion binding; negative regulation of apoptotic process;
SYVN1	5	protein binding; nucleus; zinc ion binding; protein ubiquitination; negative regulation of apoptotic process;
TFAP2A	5	protein binding; nucleus; cytoplasm; protein homodimerization activity; negative regulation of apoptotic process;
TP53BP1	5	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; DNA repair;
VEGFA	5	protein binding; cytoplasm; protein homodimerization activity; negative regulation of apoptotic process; protein heterodimerization activity;
XRCC5	5	protein binding; nucleus; cytoplasm; DNA repair; negative regulation of apoptotic process;
YAP1	5	protein binding; nucleus; response to DNA damage stimulus; cytoplasm; negative regulation of apoptotic process;
ZFR	5	protein binding; nucleus; RNA binding; cytoplasm; zinc ion binding;
BCL11A	5	nucleus; cytoplasm; zinc ion binding; protein homodimerization activity; protein heterodimerization activity;
FOXP1	5	nucleus; cytoplasm; zinc ion binding; protein homodimerization activity; protein heterodimerization activity;

Genes shared at least 2 KEGG pathways with BARD1 (count: 0)

View in gBrowse

Region: chr2:215590370..215674428 View in gBrowse