Reference |
Statistical Values/Author Comments |
Result of Statistical Analysis |
Aureli A, 2010 |
two investigated BDNF SNPs were siginificantly associated with ADHD |
Significant
|
Cho SC, 2010(a) |
The T-G-G haplotype was significantly less frequent and A-G-G was more frequent in girls with ADHD than in control girls, haplotype specific T-G-G P-value=0.005, haplotype specific A-G-G P-value=0.048, haplotype global P-value=0.027; AA genotype of rs 11030101 was significantly associated with ADHD only in girls, P-value=0.024, OR=3.00 |
Significant
|
Thakur G. A., 2012 |
SNP rs6265 mapped to this gene showed no significant association with ADHD in this study. |
Non-significant
|
Lanktree M, 2008 |
haplotype A-G-A-G-T P-value=0.0086, X2 =6.90 in the family-based sample, P-value=0.025, X2 =5.04, OR=1.47 in the combined samples; haplotype G-A-G-C-C P-value=0.0054, X2 =7.75, OR=0.46 in the case-control sample, P-value=0.0013, X2 =10.37, OR=0.50 in the combined samples; allelic and haplotype association was found |
Significant
|
Oades RD, 2008 |
3 SNPs showed significant association |
Significant
|
Gizer IR, 2009 |
The present study does not support a relation between ADHD and this gene. |
Non-significant
|
Sanchez-Mora C, 2010 |
no association between the p.Val66Met polymorphism and ADHD |
Non-significant
|
Brookes K, 2006 |
UNPHASED TDT P-value=0.165, global P-value=0.888, WHAP TDT P_sum P-value=0.534, no SNP with nominal P-value<0.05 located in this gene |
Non-significant
|
Kent L, 2005 |
evidence for preferential transmission of the valine (G) allele with a strong paternal effect supported the association between BDNF and ADHD |
Significant
|
Friedel S, 2005 |
revealed no significant differences in genotype or allele distributions |
Non-significant
|
Ribases M, 2008 |
1 SNP showed significant association with both adulthood and childhood ADHD; 1 SNP showed significant association with childhood ADHD |
Significant
|
Lee J, 2007 |
Haplotype TRANSMIT Analysis: Global P-value=0.096 on 3 df for haplotypes with frequencies>10%; P-value=0.021 for haplotype AGG (frequency 2.2%) | quantitative analyses of haplotype: smallest P-value=0.008 for AGG in Parent rated hyperactivity/impulsivity. Uncommon haplotype, A-G-G (frequency 2.2%), demonstrated a significant association with ADHD in categorical and quantitative analyses. However, the number of transmission for this haplotype was considered too low to provide a definitive result. |
Significant
|
Schimmelmann BG, 2007 |
the result did not support for an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD in this sample |
Non-significant
|
Xu X, 2007(b) |
Haplotype test for Val66/270T: TDT P-value=0.032, HHRR P-value=0.012, TRANSMIT P-value=0.014 for Taiwanese samples; TDT P-value=0.016, HHRR P-value=0.013, TRANSMIT P-value=0.07 for pooled samples. Haplotype analyses found evidence for decreased transmission of the Val66/270T haplotype in the Taiwanese sample and the pooled Taiwan/UK sample. |
Significant
|