ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	BIRC6
Symbol Alias	BRUCE
Approved Name	baculoviral IAP repeat containing 6
Previous Name	baculoviral IAP repeat-containing 6
Name Alias	apollon
Location	2p22.3
Position	chr2:32582096-32843966, +
External Links	HGNC: 13516 Entrez Gene: 57448 Ensembl: ENSG00000115760 UCSC: uc010ezu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_5	chr2:32497032-33181898 (NCBI Build 36.1 (hg18))	684866	2p22.3	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004869	cysteine-type endopeptidase inhibitor activity	Molecular Function	IMP[15200957]	6
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[15200957]	52
GO:0005575	cellular_component	Cellular Component		98
GO:0005515	protein binding	Molecular Function	IPI[18329369]	910
GO:0000922	spindle pole	Cellular Component	IDA[18329369]	22
GO:0060712	spongiotrophoblast layer development	Biological Process		1
GO:0051301	cell division	Biological Process		58
GO:0060711	labyrinthine layer development	Biological Process		1
GO:0042127	regulation of cell proliferation	Biological Process	TAS[18414036]	20
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP[15200957]; TAS[10544019]	77
GO:0030496	midbody	Cellular Component	IDA[18329369]	14
GO:0032465	regulation of cytokinesis	Biological Process	IMP[18329369]	1
GO:0016020	membrane	Cellular Component		139
GO:0016567	protein ubiquitination	Biological Process	TAS[18329369]	41
GO:0007067	mitosis	Biological Process		39
GO:0008284	positive regulation of cell proliferation	Biological Process		69
GO:0006468	protein phosphorylation	Biological Process	TAS[18329369]	53
GO:0006915	apoptotic process	Biological Process		111
GO:0005802	trans-Golgi network	Cellular Component	IDA[18329369]	28
GO:0005815	microtubule organizing center	Cellular Component	IDA[18329369]	19
GO:0005768	endosome	Cellular Component	IDA[18329369]	27
GO:0005794	Golgi apparatus	Cellular Component		157

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with BIRC6 (count: 12)

Gene Symbol	Pathway Count	Pathway List
ARHGEF2	7	protein binding; cell division; regulation of cell proliferation; negative regulation of apoptotic process; mitosis; apoptotic process; Golgi apparatus;
PLK1	7	protein binding; spindle pole; negative regulation of apoptotic process; midbody; protein ubiquitination; mitosis; protein phosphorylation;
LATS1	6	protein binding; spindle pole; cell division; mitosis; protein phosphorylation; microtubule organizing center;
LATS2	6	protein binding; spindle pole; cell division; mitosis; protein phosphorylation; microtubule organizing center;
NEK6	6	protein binding; spindle pole; mitosis; protein phosphorylation; apoptotic process; microtubule organizing center;
BIRC2	5	ubiquitin-protein ligase activity; protein binding; regulation of cell proliferation; negative regulation of apoptotic process; apoptotic process;
KLHL20	5	ubiquitin-protein ligase activity; protein binding; negative regulation of apoptotic process; protein ubiquitination; Golgi apparatus;
ARF6	5	protein binding; membrane; apoptotic process; endosome; Golgi apparatus;
CLASP2	5	protein binding; cell division; trans-Golgi network; microtubule organizing center; Golgi apparatus;
MAPK1	5	protein binding; positive regulation of cell proliferation; apoptotic process; microtubule organizing center; Golgi apparatus;
TGFBR1	5	protein binding; negative regulation of apoptotic process; positive regulation of cell proliferation; protein phosphorylation; apoptotic process;
CDC25B	5	spindle pole; cell division; mitosis; positive regulation of cell proliferation; protein phosphorylation;

Genes shared at least 2 KEGG pathways with BIRC6 (count: 0)

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Region: chr2:32582096..32843966 View in gBrowse