ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CCKBR
Approved Name	cholecystokinin B receptor
Location	11p15.4
Position	chr11:6280966-6293357, +
External Links	HGNC: 1571 Entrez Gene: 887 Ensembl: ENSG00000110148 UCSC: uc001mcp.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_29	chr11:5582423-7488751 (NCBI Build 36.1 (hg18))	1859865	11p15.4	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	IDA[10913157]	20
GO:0007586	digestion	Biological Process	TAS[7681836]	13
GO:0007166	cell surface receptor signaling pathway	Biological Process	NAS[10913157]	35
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	Biological Process	TAS[8455720]	12
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	IC[10913157]	220
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	TAS[7681836]	20
GO:0004951	cholecystokinin receptor activity	Molecular Function	TAS[7681836]	2
GO:0031741	type B gastrin/cholecystokinin receptor binding	Molecular Function	IDA[8185642]	1
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity	Molecular Function	TAS[10400698]	1
GO:0015054	gastrin receptor activity	Molecular Function	IDA[10913157]	1
GO:0008283	cell proliferation	Biological Process	TAS[10400698]	60
GO:0008284	positive regulation of cell proliferation	Biological Process	IDA[10913157]	69
GO:0007600	sensory perception	Biological Process	TAS[7681836]	5
GO:0007631	feeding behavior	Biological Process	TAS[7681836]	9

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...
hsa04971	Gastric acid secretion	12	Gastric acid is a key factor in normal upper gastrointestina...... Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen. More...

Genes shared at least 5 GO terms with CCKBR (count: 12)

Gene Symbol	Pathway Count	Pathway List
CCKAR	7	elevation of cytosolic calcium ion concentration; digestion; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; cholecystokinin receptor activity; feeding behavior;
EDNRA	7	elevation of cytosolic calcium ion concentration; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity; cell proliferation; positive regulation of cell proliferation;
BDKRB2	6	elevation of cytosolic calcium ion concentration; cell surface receptor signaling pathway; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity;
CCR5	6	elevation of cytosolic calcium ion concentration; cell surface receptor signaling pathway; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity;
CXCR2	6	elevation of cytosolic calcium ion concentration; cell surface receptor signaling pathway; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation;
PLCE1	6	elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity; cell proliferation;
CHRM3	6	digestion; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity; cell proliferation;
CHRM1	6	plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity; cell proliferation; positive regulation of cell proliferation;
C3AR1	5	elevation of cytosolic calcium ion concentration; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity;
OPRM1	5	elevation of cytosolic calcium ion concentration; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; sensory perception;
NTSR2	5	cell surface receptor signaling pathway; phospholipase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; sensory perception;
CHRM5	5	plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; lipase activity; cell proliferation;

Genes shared at least 2 KEGG pathways with CCKBR (count: 37)

Gene Symbol	Pathway Count	Pathway List
CHRM3	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Gastric acid secretion;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADCY4	2	Calcium signaling pathway; Gastric acid secretion;
CAMK2D	2	Calcium signaling pathway; Gastric acid secretion;
ITPR1	2	Calcium signaling pathway; Gastric acid secretion;
ITPR2	2	Calcium signaling pathway; Gastric acid secretion;
PLCB2	2	Calcium signaling pathway; Gastric acid secretion;
PLCB3	2	Calcium signaling pathway; Gastric acid secretion;
PRKCB	2	Calcium signaling pathway; Gastric acid secretion;

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Region: chr11:6280966..6293357 View in gBrowse