ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDK5RAP2
Previous Symbol	MCPH3
Symbol Alias	C48, FLJ10867, CEP215
Approved Name	CDK5 regulatory subunit associated protein 2
Previous Name	microcephaly, primary autosomal recessive 3
Location	9q33.3
Position	chr9:123151147-123342448, -
External Links	HGNC: 18672 Entrez Gene: 55755 Ensembl: ENSG00000136861 UCSC: uc004bkf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q33	chr9:117700000-130300000	2 (1/1/0)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process	IDA[17959831]	39

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005829	cytosol	Cellular Component		447
GO:0005856	cytoskeleton	Cellular Component	NAS[10721722]	54
GO:0005874	microtubule	Cellular Component	IDA[19553473]	52
GO:0007059	chromosome segregation	Biological Process	IMP[19282672]	14
GO:0005516	calmodulin binding	Molecular Function		32
GO:0005737	cytoplasm	Cellular Component	IDA[19282672]	690
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005813	centrosome	Cellular Component		71
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0000922	spindle pole	Cellular Component	IDA[19282672]	22
GO:0001578	microtubule bundle formation	Biological Process	IDA[19553473]	8
GO:0005515	protein binding	Molecular Function	IPI[19282672]	910
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29
GO:0000132	establishment of mitotic spindle orientation	Biological Process		7
GO:0000242	pericentriolar material	Cellular Component	IDA[17959831]	2
GO:0015631	tubulin binding	Molecular Function	IPI[17959831]	9
GO:0019901	protein kinase binding	Molecular Function	IPI[10721722]	51
GO:0007420	brain development	Biological Process	NAS[10915792]	33
GO:0008017	microtubule binding	Molecular Function	IDA[14654843]	32
GO:0032403	protein complex binding	Molecular Function		27
GO:0044212	transcription regulatory region DNA binding	Molecular Function	IDA[19282672]	23
GO:0022008	neurogenesis	Biological Process		6
GO:0030054	cell junction	Cellular Component		77
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[19282672]	80
GO:0046600	negative regulation of centriole replication	Biological Process		1
GO:0045664	regulation of neuron differentiation	Biological Process	NAS[10721722]	4
GO:0045665	negative regulation of neuron differentiation	Biological Process		13
GO:0090231	regulation of spindle checkpoint	Biological Process	IDA[19282672]	1
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[17959831]	87
GO:0051297	centrosome organization	Biological Process	IMP[18042621]	5

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with CDK5RAP2 (count: 68)

Gene Symbol	Pathway Count	Pathway List
PAFAH1B1	11	cytosol; cytoplasm; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; establishment of mitotic spindle orientation; microtubule cytoskeleton organization; microtubule binding; protein complex binding; perinuclear region of cytoplasm;
PLK1	10	cytosol; centrosome; mitotic cell cycle; spindle pole; microtubule bundle formation; protein binding; G2/M transition of mitotic cell cycle; protein kinase binding; microtubule binding; centrosome organization;
CENPJ	9	cytosol; microtubule; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; tubulin binding; protein kinase binding;
CEP57	9	cytosol; microtubule; cytoplasm; Golgi apparatus; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; microtubule binding;
CLASP1	9	cytosol; Golgi apparatus; centrosome; mitotic cell cycle; microtubule bundle formation; protein binding; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; microtubule binding;
MAP1S	9	cytosol; microtubule; microtubule bundle formation; protein binding; microtubule cytoskeleton organization; tubulin binding; brain development; microtubule binding; perinuclear region of cytoplasm;
MAPRE1	9	cytosol; microtubule; cytoplasm; Golgi apparatus; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization;
CKAP5	8	cytosol; centrosome; mitotic cell cycle; spindle pole; protein binding; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; centrosome organization;
NDE1	8	cytosol; microtubule; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; establishment of mitotic spindle orientation; microtubule binding;
TUBGCP5	8	cytosol; microtubule; centrosome; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; microtubule binding;
TUBGCP6	8	cytosol; microtubule; centrosome; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; microtubule binding;
HOOK3	8	microtubule; cytoplasm; Golgi apparatus; centrosome; protein binding; microtubule cytoskeleton organization; pericentriolar material; microtubule binding;
TPPP	8	microtubule; cytoplasm; microtubule bundle formation; protein binding; microtubule cytoskeleton organization; tubulin binding; microtubule binding; perinuclear region of cytoplasm;
APC	7	cytosol; cytoplasm; centrosome; protein binding; microtubule cytoskeleton organization; protein kinase binding; microtubule binding;
ARHGEF2	7	cytosol; microtubule; Golgi apparatus; protein binding; establishment of mitotic spindle orientation; microtubule cytoskeleton organization; microtubule binding;
CEP250	7	cytosol; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; protein kinase binding; perinuclear region of cytoplasm;
CLASP2	7	cytosol; microtubule; cytoplasm; Golgi apparatus; mitotic cell cycle; protein binding; microtubule cytoskeleton organization;
KIF11	7	cytosol; microtubule; cytoplasm; spindle pole; microtubule cytoskeleton organization; protein kinase binding; microtubule binding;
KIF23	7	cytosol; microtubule; centrosome; mitotic cell cycle; protein binding; microtubule cytoskeleton organization; microtubule binding;
NUMA1	7	cytosol; cytoplasm; mitotic cell cycle; spindle pole; protein binding; G2/M transition of mitotic cell cycle; establishment of mitotic spindle orientation;
PSRC1	7	cytosol; cytoplasm; spindle pole; microtubule bundle formation; protein binding; microtubule binding; positive regulation of transcription, DNA-dependent;
RELA	7	cytosol; cytoplasm; protein binding; protein kinase binding; protein complex binding; transcription regulatory region DNA binding; positive regulation of transcription, DNA-dependent;
SNCA	7	cytosol; cytoplasm; Golgi apparatus; protein binding; microtubule binding; cell junction; perinuclear region of cytoplasm;
TUBG1	7	cytosol; cytoplasm; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization;
TUBGCP2	7	cytosol; centrosome; mitotic cell cycle; spindle pole; protein binding; G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization;
UXT	7	cytoskeleton; cytoplasm; centrosome; protein binding; microtubule cytoskeleton organization; microtubule binding; centrosome organization;
TFAP2A	7	cytoplasm; Golgi apparatus; centrosome; protein binding; transcription regulatory region DNA binding; positive regulation of transcription, DNA-dependent; regulation of neuron differentiation;
CDC25B	6	cytosol; centrosome; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle; protein kinase binding;
CEP164	6	cytosol; cytoplasm; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
DCTN3	6	cytosol; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle; perinuclear region of cytoplasm;
GSK3B	6	cytosol; cytoplasm; centrosome; protein binding; protein kinase binding; perinuclear region of cytoplasm;
MAPK1	6	cytosol; cytoskeleton; cytoplasm; Golgi apparatus; protein binding; positive regulation of transcription, DNA-dependent;
MAPT	6	cytosol; microtubule; protein binding; microtubule cytoskeleton organization; protein kinase binding; microtubule binding;
NOS1	6	cytosol; cytoskeleton; calmodulin binding; cytoplasm; protein binding; perinuclear region of cytoplasm;
PARK2	6	cytosol; cytoplasm; Golgi apparatus; protein binding; protein kinase binding; perinuclear region of cytoplasm;
PRKAR2B	6	cytosol; cytoplasm; centrosome; mitotic cell cycle; G2/M transition of mitotic cell cycle; perinuclear region of cytoplasm;
TUBGCP4	6	cytosol; microtubule; centrosome; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle;
KATNB1	6	microtubule; cytoplasm; centrosome; spindle pole; microtubule cytoskeleton organization; microtubule binding;
NEK6	6	microtubule; chromosome segregation; cytoplasm; spindle pole; protein binding; protein kinase binding;
PRC1	6	cytoplasm; spindle pole; protein binding; microtubule cytoskeleton organization; protein kinase binding; microtubule binding;
ARRB2	5	cytosol; cytoplasm; protein binding; brain development; protein complex binding;
CCND1	5	cytosol; mitotic cell cycle; protein binding; protein kinase binding; protein complex binding;
CEP76	5	cytosol; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CNTRL	5	cytosol; centrosome; mitotic cell cycle; protein binding; G2/M transition of mitotic cell cycle;
CRYAB	5	cytosol; cytoplasm; Golgi apparatus; protein binding; microtubule binding;
GABARAPL2	5	cytosol; cytoplasm; Golgi apparatus; protein binding; microtubule binding;
ID2	5	cytosol; cytoplasm; protein binding; positive regulation of transcription, DNA-dependent; negative regulation of neuron differentiation;
ILK	5	cytosol; cytoplasm; protein binding; protein kinase binding; positive regulation of transcription, DNA-dependent;
INCENP	5	cytosol; microtubule; chromosome segregation; mitotic cell cycle; protein binding;
INPPL1	5	cytosol; cytoplasm; Golgi apparatus; protein binding; brain development;
KAT5	5	cytosol; protein binding; protein complex binding; positive regulation of transcription, DNA-dependent; perinuclear region of cytoplasm;
KIF2C	5	cytosol; chromosome segregation; mitotic cell cycle; protein binding; microtubule cytoskeleton organization;
LATS1	5	cytosol; spindle pole; protein binding; G2/M transition of mitotic cell cycle; protein kinase binding;
MAP1B	5	cytosol; microtubule; microtubule bundle formation; protein binding; cell junction;
MEN1	5	cytosol; cytoplasm; protein binding; brain development; transcription regulatory region DNA binding;
PAK1	5	cytosol; cytoplasm; Golgi apparatus; protein binding; protein kinase binding;
PDE2A	5	cytosol; cytoplasm; Golgi apparatus; protein binding; perinuclear region of cytoplasm;
PSMC3	5	cytosol; cytoplasm; mitotic cell cycle; protein binding; perinuclear region of cytoplasm;
PTTG1	5	cytosol; chromosome segregation; cytoplasm; mitotic cell cycle; protein binding;
RAN	5	cytosol; cytoplasm; protein binding; microtubule cytoskeleton organization; positive regulation of transcription, DNA-dependent;
RPTOR	5	cytosol; cytoplasm; protein binding; protein kinase binding; protein complex binding;
TJP1	5	cytosol; calmodulin binding; cytoplasm; protein binding; cell junction;
ZW10	5	cytosol; mitotic cell cycle; spindle pole; protein binding; establishment of mitotic spindle orientation;
MAP6	5	microtubule; calmodulin binding; Golgi apparatus; microtubule binding; perinuclear region of cytoplasm;
STRN3	5	calmodulin binding; cytoplasm; Golgi apparatus; protein binding; protein complex binding;
SMC3	5	cytoplasm; mitotic cell cycle; spindle pole; protein binding; microtubule cytoskeleton organization;
PTCH1	5	Golgi apparatus; protein binding; brain development; protein complex binding; perinuclear region of cytoplasm;
MARK4	5	centrosome; microtubule bundle formation; protein binding; microtubule cytoskeleton organization; microtubule binding;

Genes shared at least 2 KEGG pathways with CDK5RAP2 (count: 0)

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Region: chr9:123151147..123342448 View in gBrowse