ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CHRM1
Approved Name	cholinergic receptor, muscarinic 1
Location	11q12-q13
Position	chr11:62676151-62689012, -
External Links	HGNC: 1950 Entrez Gene: 1128 Ensembl: ENSG00000168539 UCSC: uc001nwi.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043679	axon terminus	Cellular Component		6
GO:0043270	positive regulation of ion transport	Biological Process	IGI[14657398]	1
GO:0040012	regulation of locomotion	Biological Process		3
GO:0032279	asymmetric synapse	Cellular Component		4
GO:0030054	cell junction	Cellular Component		77
GO:0016907	G-protein coupled acetylcholine receptor activity	Molecular Function		3
GO:0016020	membrane	Cellular Component	TAS[7925360]	139
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[7925360]	72
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	Biological Process	TAS[9603968]	8
GO:0006464	cellular protein modification process	Biological Process	TAS[1411529]	13
GO:0007165	signal transduction	Biological Process	TAS[9614217]	171
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8508928]	220
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	TAS[9614217]	20
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[2739737]	69
GO:0014069	postsynaptic density	Cellular Component		23
GO:0008144	drug binding	Molecular Function		19
GO:0008283	cell proliferation	Biological Process	TAS[1905013]	60
GO:0007274	neuromuscular synaptic transmission	Biological Process		5
GO:0007399	nervous system development	Biological Process	TAS[2739737]	54
GO:0007207	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	Biological Process	TAS[8139539]	1
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	Biological Process	TAS[8139539]	3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...
hsa04810	Regulation of actin cytoskeleton	48

Genes shared at least 5 GO terms with CHRM1 (count: 31)

Gene Symbol	Pathway Count	Pathway List
CHRM3	15	axon terminus; asymmetric synapse; cell junction; G-protein coupled acetylcholine receptor activity; lipase activity; postsynaptic membrane; G-protein coupled receptor signaling pathway; cellular protein modification process; signal transduction; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; drug binding; cell proliferation; nervous system development;
EDNRA	10	lipase activity; membrane; G-protein coupled receptor signaling pathway; protein kinase C-activating G-protein coupled receptor signaling pathway; signal transduction; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; positive regulation of cell proliferation; cell proliferation;
CHRM5	9	cell junction; G-protein coupled acetylcholine receptor activity; lipase activity; postsynaptic membrane; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; cell proliferation; G-protein coupled acetylcholine receptor signaling pathway;
ADORA2A	7	asymmetric synapse; membrane; postsynaptic membrane; protein kinase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; postsynaptic density;
DRD3	6	regulation of locomotion; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation; drug binding;
ACHE	6	cell junction; membrane; postsynaptic membrane; plasma membrane; cell proliferation; nervous system development;
CHRNA3	6	cell junction; postsynaptic membrane; signal transduction; plasma membrane; postsynaptic density; nervous system development;
CCKBR	6	lipase activity; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; positive regulation of cell proliferation; cell proliferation;
DRD2	5	axon terminus; plasma membrane; integral to plasma membrane; postsynaptic density; drug binding;
CHRNA4	5	cell junction; membrane; postsynaptic membrane; signal transduction; plasma membrane;
CHRNA7	5	cell junction; postsynaptic membrane; signal transduction; plasma membrane; positive regulation of cell proliferation;
CHRNB4	5	cell junction; postsynaptic membrane; signal transduction; plasma membrane; integral to plasma membrane;
GABBR2	5	cell junction; postsynaptic membrane; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane;
GABRA5	5	cell junction; postsynaptic membrane; signal transduction; plasma membrane; integral to plasma membrane;
GABRB3	5	cell junction; postsynaptic membrane; signal transduction; plasma membrane; integral to plasma membrane;
GOPC	5	cell junction; membrane; postsynaptic membrane; plasma membrane; postsynaptic density;
GRIK1	5	cell junction; postsynaptic membrane; plasma membrane; integral to plasma membrane; nervous system development;
GRIN2A	5	cell junction; postsynaptic membrane; plasma membrane; integral to plasma membrane; postsynaptic density;
GRIN2B	5	cell junction; postsynaptic membrane; plasma membrane; integral to plasma membrane; postsynaptic density;
NLGN1	5	cell junction; postsynaptic membrane; integral to plasma membrane; postsynaptic density; nervous system development;
BDKRB2	5	lipase activity; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity;
C3AR1	5	lipase activity; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity;
CASR	5	lipase activity; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity;
CCR5	5	lipase activity; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity;
PLCE1	5	lipase activity; protein kinase C-activating G-protein coupled receptor signaling pathway; plasma membrane; phosphatidylinositol phospholipase C activity; cell proliferation;
CXCR2	5	membrane; signal transduction; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation;
HTR4	5	membrane; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation;
ADRA1D	5	G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation; cell proliferation;
ADRA2A	5	G-protein coupled receptor signaling pathway; signal transduction; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation;
HTR1B	5	G-protein coupled receptor signaling pathway; protein kinase C-activating G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; drug binding;
HTR2A	5	plasma membrane; integral to plasma membrane; phosphatidylinositol phospholipase C activity; positive regulation of cell proliferation; drug binding;

Genes shared at least 2 KEGG pathways with CHRM1 (count: 30)

Gene Symbol	Pathway Count	Pathway List
BDKRB2	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Regulation of actin cytoskeleton;
CHRM3	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Regulation of actin cytoskeleton;
CHRM5	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Regulation of actin cytoskeleton;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr11:62676151..62689012 View in gBrowse