ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CHRM5
Approved Name	cholinergic receptor, muscarinic 5
Location	15q26
Position	chr15:34261089-34357295, +
External Links	HGNC: 1954 Entrez Gene: 1133 Ensembl: ENSG00000184984 UCSC: uc001zhk.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_44	chr15:30688712-32587887 (NCBI Build 36.1 (hg18))	1871368	15q13.3-15q14	Gain	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005887	integral to plasma membrane	Cellular Component	TAS[3272174]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway	Biological Process	TAS[3272174]	3
GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	Biological Process	TAS[8663391]	1
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	TAS[1905013]	20
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0030054	cell junction	Cellular Component		77
GO:0060304	regulation of phosphatidylinositol dephosphorylation	Biological Process		1
GO:0015872	dopamine transport	Biological Process		3
GO:0008283	cell proliferation	Biological Process	TAS[8063729]	60
GO:0016907	G-protein coupled acetylcholine receptor activity	Molecular Function		3

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...
hsa04810	Regulation of actin cytoskeleton	48

Genes shared at least 5 GO terms with CHRM5 (count: 4)

Gene Symbol	Pathway Count	Pathway List
CHRM1	9	integral to plasma membrane; plasma membrane; G-protein coupled acetylcholine receptor signaling pathway; phosphatidylinositol phospholipase C activity; postsynaptic membrane; cell junction; cell proliferation; G-protein coupled acetylcholine receptor activity; lipase activity;
CHRM3	8	integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity; postsynaptic membrane; cell junction; cell proliferation; G-protein coupled acetylcholine receptor activity; lipase activity;
CCKBR	5	integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity; cell proliferation; lipase activity;
EDNRA	5	integral to plasma membrane; plasma membrane; phosphatidylinositol phospholipase C activity; cell proliferation; lipase activity;

Genes shared at least 2 KEGG pathways with CHRM5 (count: 30)

Gene Symbol	Pathway Count	Pathway List
BDKRB2	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Regulation of actin cytoskeleton;
CHRM1	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Regulation of actin cytoskeleton;
CHRM3	3	Neuroactive ligand-receptor interaction; Calcium signaling pathway; Regulation of actin cytoskeleton;
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr15:34261089..34357295 View in gBrowse