ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CNGA4
Previous Symbol	CNCA2, CNGB2
Symbol Alias	OCNC2, OCNCb, CNG5
Approved Name	cyclic nucleotide gated channel alpha 4
Previous Name	cyclic nucleotide gated channel beta 2
Location	11p15.4
Position	chr11:6255995-6265707, +
External Links	HGNC: 2152 Entrez Gene: 1262 Ensembl: ENSG00000132259 UCSC: uc001mco.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_29	chr11:5582423-7488751 (NCBI Build 36.1 (hg18))	1859865	11p15.4	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 5)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 5)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005216	ion channel activity	Molecular Function	6
GO:0007608	sensory perception of smell	Biological Process	19
GO:0050896	response to stimulus	Biological Process	8
GO:0016021	integral to membrane	Cellular Component	845
GO:0030552	cAMP binding	Molecular Function	5

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04740	Olfactory transduction	173	Within the compact cilia of the olfactory receptor neurons (...... Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert inactive forms of protein kinase A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase. More...

Genes shared at least 5 GO terms with CNGA4 (count: 0)

Genes shared at least 2 KEGG pathways with CNGA4 (count: 0)

View in gBrowse

Region: chr11:6255995..6265707 View in gBrowse