ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CRYAB
Previous Symbol	CRYA2
Symbol Alias	HSPB5
Approved Name	crystallin, alpha B
Location	11q22.3-q23.1
Position	chr11:111779289-111794446, -
External Links	HGNC: 2389 Entrez Gene: 1410 Ensembl: ENSG00000109846 UCSC: uc001pmf.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 36)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046872	metal ion binding	Molecular Function		170
GO:0051082	unfolded protein binding	Molecular Function	IPI[16303126]	19
GO:0051260	protein homooligomerization	Biological Process	IDA[16303126]	34
GO:0051403	stress-activated MAPK cascade	Biological Process		10
GO:0060561	apoptotic process involved in morphogenesis	Biological Process		2
GO:2000378	negative regulation of reactive oxygen species metabolic process	Biological Process		4
GO:0031109	microtubule polymerization or depolymerization	Biological Process		1
GO:0032355	response to estradiol stimulus	Biological Process		18
GO:0032387	negative regulation of intracellular transport	Biological Process	IDA[14752512]	3
GO:0032432	actin filament bundle	Cellular Component		2
GO:0042542	response to hydrogen peroxide	Biological Process		6
GO:0042803	protein homodimerization activity	Molecular Function	IPI[19646995]	113
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[14752512]	77
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	Biological Process		9
GO:0007568	aging	Biological Process		29
GO:0007517	muscle organ development	Biological Process		16
GO:0002088	lens development in camera-type eye	Biological Process		7
GO:0009986	cell surface	Cellular Component		70
GO:0001666	response to hypoxia	Biological Process		34
GO:0008017	microtubule binding	Molecular Function		32
GO:0005515	protein binding	Molecular Function	IPI[16225851]	910
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0005212	structural constituent of eye lens	Molecular Function		5
GO:0010629	negative regulation of gene expression	Biological Process		13
GO:0005737	cytoplasm	Cellular Component		690
GO:0030308	negative regulation of cell growth	Biological Process		21
GO:0005634	nucleus	Cellular Component	IDA[19464326]	770
GO:0030018	Z disc	Cellular Component		17
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005739	mitochondrion	Cellular Component		183
GO:0005886	plasma membrane	Cellular Component		772
GO:0005829	cytosol	Cellular Component		447
GO:0006457	protein folding	Biological Process		28
GO:0006006	glucose metabolic process	Biological Process		19
GO:0007021	tubulin complex assembly	Biological Process		2
GO:0006936	muscle contraction	Biological Process	TAS[9731540]	18

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04141	Protein processing in endoplasmic reticulum	26	The endoplasmic reticulum (ER) is a subcellular organelle wh...... The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. More...

Genes shared at least 5 GO terms with CRYAB (count: 112)

Gene Symbol	Pathway Count	Pathway List
SNCA	11	negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; aging; microtubule binding; protein binding; cytoplasm; nucleus; Golgi apparatus; mitochondrion; plasma membrane; cytosol;
CEP57	9	protein homooligomerization; protein homodimerization activity; microtubule binding; protein binding; microtubule cytoskeleton; cytoplasm; nucleus; Golgi apparatus; cytosol;
PDE2A	8	metal ion binding; protein homodimerization activity; protein binding; cytoplasm; nucleus; Golgi apparatus; plasma membrane; cytosol;
MAPK1	8	stress-activated MAPK cascade; protein binding; microtubule cytoskeleton; cytoplasm; nucleus; Golgi apparatus; mitochondrion; cytosol;
KARS	7	metal ion binding; microtubule cytoskeleton; cytoplasm; nucleus; mitochondrion; plasma membrane; cytosol;
PRKAA1	7	metal ion binding; negative regulation of apoptotic process; response to hypoxia; protein binding; nucleus; cytosol; glucose metabolic process;
PRKD1	7	metal ion binding; protein binding; cytoplasm; nucleus; Golgi apparatus; plasma membrane; cytosol;
HSPA8	7	unfolded protein binding; cell surface; protein binding; nucleus; plasma membrane; cytosol; protein folding;
SLC6A4	7	protein homooligomerization; response to estradiol stimulus; protein homodimerization activity; response to hypoxia; protein binding; plasma membrane; cytosol;
MAPK3	7	stress-activated MAPK cascade; protein binding; microtubule cytoskeleton; nucleus; Golgi apparatus; mitochondrion; cytosol;
TFAP2A	7	negative regulation of reactive oxygen species metabolic process; protein homodimerization activity; negative regulation of apoptotic process; protein binding; cytoplasm; nucleus; Golgi apparatus;
GHR	7	response to estradiol stimulus; protein homodimerization activity; cell surface; protein binding; nucleus; mitochondrion; plasma membrane;
TH	7	response to estradiol stimulus; response to hypoxia; protein binding; cytoplasm; nucleus; mitochondrion; cytosol;
RELA	7	response to hydrogen peroxide; negative regulation of apoptotic process; aging; protein binding; cytoplasm; nucleus; cytosol;
ACHE	7	protein homodimerization activity; muscle organ development; cell surface; protein binding; nucleus; Golgi apparatus; plasma membrane;
BNIP3	7	protein homodimerization activity; negative regulation of apoptotic process; response to hypoxia; protein binding; cytoplasm; nucleus; mitochondrion;
VEGFA	7	protein homodimerization activity; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cell surface; response to hypoxia; protein binding; cytoplasm;
APC	7	negative regulation of apoptotic process; microtubule binding; protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
PAK1	7	response to hypoxia; protein binding; cytoplasm; Z disc; Golgi apparatus; plasma membrane; cytosol;
INPPL1	7	protein binding; negative regulation of gene expression; cytoplasm; Golgi apparatus; plasma membrane; cytosol; glucose metabolic process;
WWOX	7	protein binding; cytoplasm; nucleus; Golgi apparatus; mitochondrion; plasma membrane; cytosol;
AIFM3	6	metal ion binding; cytoplasm; nucleus; mitochondrion; plasma membrane; cytosol;
ALKBH8	6	metal ion binding; protein binding; microtubule cytoskeleton; cytoplasm; nucleus; cytosol;
ENPP1	6	metal ion binding; protein homodimerization activity; cell surface; protein binding; negative regulation of cell growth; plasma membrane;
FBP1	6	metal ion binding; protein binding; cytoplasm; negative regulation of cell growth; cytosol; glucose metabolic process;
IREB2	6	metal ion binding; aging; protein binding; cytoplasm; mitochondrion; cytosol;
AIP	6	unfolded protein binding; protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
UXT	6	unfolded protein binding; microtubule binding; protein binding; cytoplasm; nucleus; protein folding;
GOPC	6	protein homooligomerization; protein homodimerization activity; protein binding; cytoplasm; Golgi apparatus; plasma membrane;
AATF	6	negative regulation of reactive oxygen species metabolic process; negative regulation of apoptotic process; protein binding; cytoplasm; nucleus; Golgi apparatus;
STRN3	6	response to estradiol stimulus; protein binding; cytoplasm; nucleus; Golgi apparatus; plasma membrane;
PAFAH1B1	6	protein homodimerization activity; microtubule binding; protein binding; cytoplasm; nucleus; cytosol;
PYCARD	6	protein homodimerization activity; protein binding; cytoplasm; nucleus; mitochondrion; cytosol;
CBL	6	negative regulation of apoptotic process; protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
GSK3B	6	negative regulation of apoptotic process; protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
GSTP1	6	negative regulation of apoptotic process; protein binding; cytoplasm; nucleus; mitochondrion; cytosol;
KLHL20	6	negative regulation of apoptotic process; cell surface; protein binding; cytoplasm; nucleus; Golgi apparatus;
MALT1	6	negative regulation of apoptotic process; protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
TNFAIP3	6	negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; protein binding; cytoplasm; nucleus; cytosol;
PRC1	6	microtubule binding; protein binding; microtubule cytoskeleton; cytoplasm; nucleus; plasma membrane;
PSRC1	6	microtubule binding; protein binding; microtubule cytoskeleton; cytoplasm; negative regulation of cell growth; cytosol;
FLCN	6	protein binding; negative regulation of gene expression; cytoplasm; negative regulation of cell growth; nucleus; plasma membrane;
PARK2	6	protein binding; cytoplasm; nucleus; Golgi apparatus; mitochondrion; cytosol;
CACNA1A	5	metal ion binding; protein binding; cytoplasm; nucleus; plasma membrane;
CACNA1C	5	metal ion binding; protein binding; cytoplasm; Z disc; plasma membrane;
DGCR8	5	metal ion binding; protein binding; microtubule cytoskeleton; cytoplasm; nucleus;
GNAO1	5	metal ion binding; response to hydrogen peroxide; aging; plasma membrane; muscle contraction;
PPP1CA	5	metal ion binding; protein binding; cytoplasm; nucleus; cytosol;
PPP4C	5	metal ion binding; protein binding; cytoplasm; nucleus; plasma membrane;
PRLR	5	metal ion binding; protein homodimerization activity; negative regulation of apoptotic process; cell surface; plasma membrane;
PTS	5	metal ion binding; protein homodimerization activity; cytoplasm; mitochondrion; cytosol;
ROCK2	5	metal ion binding; protein binding; nucleus; plasma membrane; cytosol;
SMG1	5	metal ion binding; protein binding; cytoplasm; nucleus; cytosol;
TGFBR1	5	metal ion binding; negative regulation of apoptotic process; lens development in camera-type eye; protein binding; plasma membrane;
HSPA5	5	unfolded protein binding; negative regulation of apoptotic process; cell surface; protein binding; nucleus;
EHD3	5	protein homooligomerization; protein binding; cytoplasm; nucleus; plasma membrane;
RIPK3	5	protein homooligomerization; protein binding; mitochondrion; plasma membrane; cytosol;
MAPK7	5	stress-activated MAPK cascade; negative regulation of apoptotic process; protein binding; nucleus; cytosol;
BIRC3	5	negative regulation of reactive oxygen species metabolic process; negative regulation of apoptotic process; protein binding; cytoplasm; nucleus;
BAD	5	response to estradiol stimulus; response to hydrogen peroxide; protein binding; mitochondrion; cytosol;
CTGF	5	response to estradiol stimulus; negative regulation of gene expression; Golgi apparatus; plasma membrane; cytosol;
FGF10	5	response to estradiol stimulus; negative regulation of apoptotic process; cell surface; nucleus; plasma membrane;
MAPT	5	negative regulation of intracellular transport; microtubule binding; protein binding; plasma membrane; cytosol;
ADRB3	5	protein homodimerization activity; aging; protein binding; nucleus; plasma membrane;
BARD1	5	protein homodimerization activity; negative regulation of apoptotic process; protein binding; cytoplasm; nucleus;
CCDC88A	5	protein homodimerization activity; microtubule binding; Golgi apparatus; plasma membrane; cytosol;
CORO1A	5	protein homodimerization activity; protein binding; cytoplasm; nucleus; plasma membrane;
CRYM	5	protein homodimerization activity; cytoplasm; nucleus; mitochondrion; plasma membrane;
DAXX	5	protein homodimerization activity; protein binding; cytoplasm; nucleus; cytosol;
FZD4	5	protein homodimerization activity; cell surface; protein binding; cytoplasm; plasma membrane;
MTMR2	5	protein homodimerization activity; protein binding; cytoplasm; nucleus; cytosol;
PDCD10	5	protein homodimerization activity; negative regulation of apoptotic process; protein binding; plasma membrane; cytosol;
RNF40	5	protein homodimerization activity; protein binding; cytoplasm; nucleus; plasma membrane;
SHMT1	5	protein homodimerization activity; cytoplasm; nucleus; mitochondrion; cytosol;
TRIM5	5	protein homodimerization activity; protein binding; cytoplasm; nucleus; Golgi apparatus;
ARHGEF2	5	negative regulation of apoptotic process; microtubule binding; protein binding; Golgi apparatus; cytosol;
FLT4	5	negative regulation of apoptotic process; protein binding; cytoplasm; nucleus; plasma membrane;
MIF	5	negative regulation of apoptotic process; cell surface; protein binding; negative regulation of gene expression; cytoplasm;
PIK3CG	5	negative regulation of apoptotic process; protein binding; cytoplasm; plasma membrane; cytosol;
PLK1	5	negative regulation of apoptotic process; microtubule binding; protein binding; nucleus; cytosol;
PRDX5	5	negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; cytoplasm; nucleus; mitochondrion;
SORT1	5	negative regulation of apoptotic process; cell surface; cytoplasm; Golgi apparatus; plasma membrane;
YAP1	5	negative regulation of apoptotic process; protein binding; cytoplasm; nucleus; cytosol;
ADRB1	5	aging; protein binding; cytoplasm; nucleus; plasma membrane;
CAV3	5	muscle organ development; cell surface; protein binding; Z disc; plasma membrane;
CRYGD	5	lens development in camera-type eye; protein binding; structural constituent of eye lens; cytoplasm; nucleus;
ADAM17	5	cell surface; response to hypoxia; protein binding; cytoplasm; plasma membrane;
EGLN3	5	response to hypoxia; protein binding; cytoplasm; nucleus; cytosol;
SOD3	5	response to hypoxia; protein binding; nucleus; mitochondrion; cytosol;
CDK5RAP2	5	microtubule binding; protein binding; cytoplasm; Golgi apparatus; cytosol;
GABARAPL2	5	microtubule binding; protein binding; cytoplasm; Golgi apparatus; cytosol;
TPPP	5	microtubule binding; protein binding; cytoplasm; nucleus; plasma membrane;
APBB1	5	protein binding; cytoplasm; negative regulation of cell growth; nucleus; plasma membrane;
ARRB1	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
ARRB2	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
BAIAP2	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
CLASP2	5	protein binding; cytoplasm; Golgi apparatus; plasma membrane; cytosol;
COG3	5	protein binding; cytoplasm; nucleus; Golgi apparatus; plasma membrane;
CTNND1	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
DCPS	5	protein binding; cytoplasm; nucleus; mitochondrion; cytosol;
FLNC	5	protein binding; cytoplasm; Z disc; plasma membrane; cytosol;
GOLPH3	5	protein binding; cytoplasm; mitochondrion; plasma membrane; cytosol;
ID2	5	protein binding; negative regulation of gene expression; cytoplasm; nucleus; cytosol;
NCK1	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
PRKCB	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
PRKG1	5	protein binding; cytoplasm; Golgi apparatus; plasma membrane; cytosol;
SART1	5	protein binding; cytoplasm; nucleus; Golgi apparatus; cytosol;
STXBP3	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
SYTL2	5	protein binding; cytoplasm; nucleus; Golgi apparatus; plasma membrane;
TJP1	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
WWP1	5	protein binding; cytoplasm; nucleus; plasma membrane; cytosol;
PERP	5	cytoplasm; nucleus; Golgi apparatus; mitochondrion; plasma membrane;

Genes shared at least 2 KEGG pathways with CRYAB (count: 0)

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Region: chr11:111779289..111794446 View in gBrowse