ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CTU2
Previous Symbol	C16orf84
Symbol Alias	NCS2
Approved Name	cytosolic thiouridylase subunit 2 homolog (S. pombe)
Previous Name	chromosome 16 open reading frame 84
Location	16q24.3
Position	chr16:88772891-88781794, +
External Links	HGNC: 28005 Entrez Gene: 348180 Ensembl: ENSG00000174177 UCSC: uc002flm.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043234	protein complex	Cellular Component	IDA[19017811]	45
GO:0005739	mitochondrion	Cellular Component		183
GO:0034227	tRNA thio-modification	Biological Process	NAS[19017811]	1
GO:0005515	protein binding	Molecular Function	IPI[19017811]	910
GO:0005737	cytoplasm	Cellular Component		690
GO:0002098	tRNA wobble uridine modification	Biological Process	NAS[19017811]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04122	Sulfur relay system	1	Ubiquitin and ubiquitin-like proteins (Ubls) are signalling ...... Ubiquitin and ubiquitin-like proteins (Ubls) are signalling messengers that control many cellular functions, such as cell proliferation, apoptosis, and DNA repair. It is suggested that Ub-protein modification evolved from prokaryotic sulfurtransfer systems. Molybdenum cofactor (Moco) and thiamin are sulfur-containing cofactors whose biosynthesis includes a key sulfur transfer step that uses unique sulfur carrier proteins, MoaD and ThiS. Ubiquitin, MoaD, and ThiS are all structurally related proteins whose C-termini are activated through adenylation by homologous E1-like enzymes. s2T biosynthesis may share similar chemistry with Moco and thiamin synthesis. In Saccharomyces cerevisiae, Urm1 and Uba4 function as part of a ubl protein conjugation system, though they have sequence homology to bacterial sulfur-transfer enzymes and the ability to function in sulfur transfer. More...

Genes shared at least 5 GO terms with CTU2 (count: 0)

Genes shared at least 2 KEGG pathways with CTU2 (count: 0)

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Region: chr16:88772891..88781794 View in gBrowse