ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	DLAT
Previous Symbol	DLTA
Symbol Alias	PDC-E2
Approved Name	dihydrolipoamide S-acetyltransferase
Name Alias	E2 component of pyruvate dehydrogenase complex
Location	11q23.1
Position	chr11:111895538-111935114, +
External Links	HGNC: 2896 Entrez Gene: 1737 Ensembl: ENSG00000150768 UCSC: uc001pmo.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate	Biological Process		1
GO:0006099	tricarboxylic acid cycle	Biological Process		2
GO:0005515	protein binding	Molecular Function	IPI[15861126]	910
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0004742	dihydrolipoyllysine-residue acetyltransferase activity	Molecular Function	NAS[3191998]	1
GO:0006085	acetyl-CoA biosynthetic process	Biological Process		2
GO:0006090	pyruvate metabolic process	Biological Process		3
GO:0005967	mitochondrial pyruvate dehydrogenase complex	Cellular Component	NAS[3191998]	1
GO:0006006	glucose metabolic process	Biological Process		19

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00020	Citrate cycle (TCA cycle)	3	The citrate cycle (TCA cycle, Krebs cycle) is an important a...... The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011]. More...
hsa00620	Pyruvate metabolism	7
hsa00010	Glycolysis / Gluconeogenesis	11	Glycolysis is the process of converting glucose into pyruvat...... Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. More...

Genes shared at least 5 GO terms with DLAT (count: 0)

Genes shared at least 2 KEGG pathways with DLAT (count: 15)

Gene Symbol	Pathway Count	Pathway List
ALDH3A2	3	Metabolic pathways; Pyruvate metabolism; Glycolysis / Gluconeogenesis;
PC	3	Metabolic pathways; Citrate cycle (TCA cycle); Pyruvate metabolism;
ACACA	2	Metabolic pathways; Pyruvate metabolism;
ACAT1	2	Metabolic pathways; Pyruvate metabolism;
ALDH3A1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDH3B1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDH3B2	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDOA	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ALDOB	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
FBP1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
FBP2	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
HK1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
HKDC1	2	Metabolic pathways; Glycolysis / Gluconeogenesis;
ME3	2	Metabolic pathways; Pyruvate metabolism;
SDHD	2	Metabolic pathways; Citrate cycle (TCA cycle);

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Region: chr11:111895538..111935114 View in gBrowse