ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DUSP1
Previous Symbol	PTPN10
Symbol Alias	HVH1, CL100, MKP-1
Approved Name	dual specificity phosphatase 1
Location	5q35.1
Position	chr5:172195093-172198203, -
External Links	HGNC: 3064 Entrez Gene: 1843 Ensembl: ENSG00000120129 UCSC: uc003mbv.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Mick E, 2010	No significant or Trend associated SNP was mapped in this gene.	Non-significant

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs7702178	Chr5:172196997(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs13170779	Chr5:172201901(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs322353	Chr5:172192868(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007049	cell cycle	Biological Process		31
GO:0008330	protein tyrosine/threonine phosphatase activity	Molecular Function		2
GO:0051592	response to calcium ion	Biological Process		9
GO:0006470	protein dephosphorylation	Biological Process		18
GO:0006979	response to oxidative stress	Biological Process	TAS[1406996]	17
GO:0032355	response to estradiol stimulus	Biological Process		18
GO:0032526	response to retinoic acid	Biological Process		7
GO:0009416	response to light stimulus	Biological Process		7
GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity	Molecular Function		3
GO:0035556	intracellular signal transduction	Biological Process		44
GO:0042542	response to hydrogen peroxide	Biological Process		6
GO:0000188	inactivation of MAPK activity	Biological Process		3
GO:0032870	cellular response to hormone stimulus	Biological Process		7
GO:0033574	response to testosterone stimulus	Biological Process		2
GO:0051384	response to glucocorticoid stimulus	Biological Process		17
GO:0005515	protein binding	Molecular Function	IPI[16286470]	910
GO:0051591	response to cAMP	Biological Process		11
GO:0005654	nucleoplasm	Cellular Component		183
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0001706	endoderm formation	Biological Process		3
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Molecular Function	TAS[1406996]	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with DUSP1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
DUSP2	8	protein tyrosine/threonine phosphatase activity; protein dephosphorylation; MAP kinase tyrosine/serine/threonine phosphatase activity; inactivation of MAPK activity; protein binding; nucleoplasm; regulation of apoptotic process; endoderm formation;
BAD	7	response to calcium ion; response to estradiol stimulus; response to hydrogen peroxide; response to testosterone stimulus; response to glucocorticoid stimulus; protein binding; positive regulation of apoptotic process;
IGFBP2	5	response to estradiol stimulus; response to retinoic acid; cellular response to hormone stimulus; response to glucocorticoid stimulus; protein binding;

Genes shared at least 2 KEGG pathways with DUSP1 (count: 0)

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Region: chr5:172195093..172198203 View in gBrowse