ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	EDNRA
Approved Name	endothelin receptor type A
Location	4
Position	chr4:148401907-148466106, +
External Links	HGNC: 3179 Entrez Gene: 1909 Ensembl: ENSG00000151617 UCSC: uc003iky.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 50)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016298	lipase activity	Molecular Function		49

GO terms by database search (count: 49)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001569	patterning of blood vessels	Biological Process		7
GO:0001701	in utero embryonic development	Biological Process		32
GO:0001666	response to hypoxia	Biological Process		34
GO:0001934	positive regulation of protein phosphorylation	Biological Process		22
GO:0001821	histamine secretion	Biological Process		1
GO:0004435	phosphatidylinositol phospholipase C activity	Molecular Function	TAS[8702836]	20
GO:0003094	glomerular filtration	Biological Process		2
GO:0004962	endothelin receptor activity	Molecular Function	NAS[8611157]	1
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1326535]	220
GO:0006939	smooth muscle contraction	Biological Process	NAS[9284755]	10
GO:0007165	signal transduction	Biological Process	TAS[1326535]	171
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	NAS[8611157]	72
GO:0007190	activation of adenylate cyclase activity	Biological Process	TAS[8702836]	9
GO:0007202	activation of phospholipase C activity	Biological Process	TAS[8702836]	12
GO:0007204	elevation of cytosolic calcium ion concentration	Biological Process	TAS[1849646]	20
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	Biological Process		8
GO:0007266	Rho protein signal transduction	Biological Process		11
GO:0007507	heart development	Biological Process		23
GO:0007568	aging	Biological Process		29
GO:0007585	respiratory gaseous exchange	Biological Process		4
GO:0008283	cell proliferation	Biological Process	NAS[9284755]	60
GO:0008284	positive regulation of cell proliferation	Biological Process		69
GO:0030818	negative regulation of cAMP biosynthetic process	Biological Process		7
GO:0030315	T-tubule	Cellular Component		12
GO:0019233	sensory perception of pain	Biological Process		17
GO:0016020	membrane	Cellular Component		139
GO:0015758	glucose transport	Biological Process		13
GO:0014824	artery smooth muscle contraction	Biological Process	IMP[8982507]	1
GO:0014032	neural crest cell development	Biological Process		3
GO:0048144	fibroblast proliferation	Biological Process		1
GO:0043278	response to morphine	Biological Process		9
GO:0043084	penile erection	Biological Process		1
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0042482	positive regulation of odontogenesis	Biological Process		1
GO:0042310	vasoconstriction	Biological Process	IMP[8982507]	2
GO:0032496	response to lipopolysaccharide	Biological Process		22
GO:0031965	nuclear membrane	Cellular Component		27
GO:0060322	head development	Biological Process		3
GO:0070374	positive regulation of ERK1 and ERK2 cascade	Biological Process		22
GO:0051482	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	Biological Process		5
GO:0060137	maternal process involved in parturition	Biological Process		2
GO:0050729	positive regulation of inflammatory response	Biological Process		8
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	Biological Process		5
GO:0048659	smooth muscle cell proliferation	Biological Process		1
GO:0050678	regulation of epithelial cell proliferation	Biological Process		2
GO:0090184	positive regulation of kidney development	Biological Process		2
GO:0071260	cellular response to mechanical stimulus	Biological Process		14
GO:0090023	positive regulation of neutrophil chemotaxis	Biological Process		5

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04270	Vascular smooth muscle contraction	33	The vascular smooth muscle cell (VSMC) is a highly specializ...... The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. More...
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with EDNRA (count: 40)

Gene Symbol	Pathway Count	Pathway List
ADRA1A	11	plasma membrane; integral to plasma membrane; smooth muscle contraction; signal transduction; G-protein coupled receptor signaling pathway; activation of phospholipase C activity; elevation of cytosolic calcium ion concentration; aging; T-tubule; nuclear membrane; positive regulation of ERK1 and ERK2 cascade;
CHRM1	10	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; signal transduction; G-protein coupled receptor signaling pathway; protein kinase C-activating G-protein coupled receptor signaling pathway; cell proliferation; positive regulation of cell proliferation; lipase activity; membrane;
BDKRB2	8	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; smooth muscle contraction; G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; lipase activity; negative regulation of apoptotic process;
CHRM3	8	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; smooth muscle contraction; signal transduction; G-protein coupled receptor signaling pathway; cell proliferation; lipase activity;
VEGFA	7	patterning of blood vessels; in utero embryonic development; response to hypoxia; positive regulation of protein phosphorylation; positive regulation of cell proliferation; membrane; negative regulation of apoptotic process;
C3AR1	7	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; lipase activity; positive regulation of neutrophil chemotaxis;
CCKBR	7	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; elevation of cytosolic calcium ion concentration; cell proliferation; positive regulation of cell proliferation; lipase activity;
PLCE1	7	phosphatidylinositol phospholipase C activity; plasma membrane; elevation of cytosolic calcium ion concentration; protein kinase C-activating G-protein coupled receptor signaling pathway; heart development; cell proliferation; lipase activity;
ADRA2A	7	plasma membrane; integral to plasma membrane; signal transduction; G-protein coupled receptor signaling pathway; Rho protein signal transduction; positive regulation of cell proliferation; negative regulation of cAMP biosynthetic process;
TGFBR1	6	in utero embryonic development; plasma membrane; signal transduction; heart development; positive regulation of cell proliferation; negative regulation of apoptotic process;
ADAM17	6	response to hypoxia; positive regulation of protein phosphorylation; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation; response to lipopolysaccharide;
DRD2	6	response to hypoxia; plasma membrane; integral to plasma membrane; response to morphine; positive regulation of ERK1 and ERK2 cascade; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;
FLT4	6	positive regulation of protein phosphorylation; plasma membrane; integral to plasma membrane; positive regulation of cell proliferation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
CCR5	6	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; lipase activity;
HTR2A	6	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; aging; positive regulation of cell proliferation; sensory perception of pain;
ADRA1B	6	plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; cell proliferation; response to morphine; nuclear membrane;
ADRB1	6	plasma membrane; integral to plasma membrane; activation of adenylate cyclase activity; Rho protein signal transduction; aging; sensory perception of pain;
CNR1	6	plasma membrane; integral to plasma membrane; aging; sensory perception of pain; response to morphine; response to lipopolysaccharide;
CXCR2	6	plasma membrane; integral to plasma membrane; signal transduction; elevation of cytosolic calcium ion concentration; positive regulation of cell proliferation; membrane;
LPAR1	6	plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; activation of phospholipase C activity; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway;
TLR4	6	plasma membrane; integral to plasma membrane; response to lipopolysaccharide; positive regulation of ERK1 and ERK2 cascade; positive regulation of inflammatory response; cellular response to mechanical stimulus;
CHRNA4	5	response to hypoxia; plasma membrane; signal transduction; sensory perception of pain; membrane;
ERBB2	5	positive regulation of protein phosphorylation; plasma membrane; signal transduction; heart development; cell proliferation;
FGF4	5	positive regulation of protein phosphorylation; signal transduction; positive regulation of cell proliferation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade;
CASR	5	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; lipase activity;
CHRM5	5	phosphatidylinositol phospholipase C activity; plasma membrane; integral to plasma membrane; cell proliferation; lipase activity;
ADORA2A	5	plasma membrane; integral to plasma membrane; activation of adenylate cyclase activity; protein kinase C-activating G-protein coupled receptor signaling pathway; membrane;
ADRA1D	5	plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; cell proliferation; positive regulation of cell proliferation;
ADRBK1	5	plasma membrane; signal transduction; activation of phospholipase C activity; heart development; membrane;
DRD1	5	plasma membrane; integral to plasma membrane; activation of adenylate cyclase activity; elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway; positive regulation of release of sequestered calcium ion into cytosol;
DRD3	5	plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; positive regulation of cell proliferation; response to morphine;
HTR1B	5	plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; protein kinase C-activating G-protein coupled receptor signaling pathway; negative regulation of cAMP biosynthetic process;
HTR4	5	plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; positive regulation of cell proliferation; membrane;
OPRM1	5	plasma membrane; integral to plasma membrane; elevation of cytosolic calcium ion concentration; sensory perception of pain; positive regulation of ERK1 and ERK2 cascade;
OXTR	5	plasma membrane; integral to plasma membrane; elevation of cytosolic calcium ion concentration; heart development; maternal process involved in parturition;
PIK3CG	5	plasma membrane; G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; membrane; negative regulation of apoptotic process;
S1PR3	5	plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of cell proliferation;
SNCA	5	plasma membrane; aging; negative regulation of apoptotic process; response to lipopolysaccharide; positive regulation of release of sequestered calcium ion into cytosol;
MS4A2	5	integral to plasma membrane; G-protein coupled receptor signaling pathway; activation of phospholipase C activity; protein kinase C-activating G-protein coupled receptor signaling pathway; cell proliferation;
IL6	5	aging; positive regulation of cell proliferation; negative regulation of apoptotic process; response to lipopolysaccharide; positive regulation of ERK1 and ERK2 cascade;

Genes shared at least 2 KEGG pathways with EDNRA (count: 40)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRA1A	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRA1B	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRA1D	3	Neuroactive ligand-receptor interaction; Vascular smooth muscle contraction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADCY4	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1C	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1D	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1F	2	Vascular smooth muscle contraction; Calcium signaling pathway;
CACNA1S	2	Vascular smooth muscle contraction; Calcium signaling pathway;
ITPR1	2	Vascular smooth muscle contraction; Calcium signaling pathway;
ITPR2	2	Vascular smooth muscle contraction; Calcium signaling pathway;
PLCB2	2	Vascular smooth muscle contraction; Calcium signaling pathway;
PLCB3	2	Vascular smooth muscle contraction; Calcium signaling pathway;
PRKCB	2	Vascular smooth muscle contraction; Calcium signaling pathway;

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Region: chr4:148401907..148466106 View in gBrowse