ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ENPP3
Previous Symbol	PDNP3
Symbol Alias	PD-IBETA, gp130RB13-6, B10, CD203c
Approved Name	ectonucleotide pyrophosphatase/phosphodiesterase 3
Location	6q22
Position	chr6:131949582-132068553, +
External Links	HGNC: 3358 Entrez Gene: 5169 Ensembl: ENSG00000154269 UCSC: uc003qcv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[10513816]	87
GO:0046872	metal ion binding	Molecular Function		170
GO:0047429	nucleoside-triphosphate diphosphatase activity	Molecular Function	IDA[10513816]	3
GO:0004551	nucleotide diphosphatase activity	Molecular Function	TAS[9344668]	2
GO:0030505	inorganic diphosphate transport	Biological Process	IDA[10513816]	2
GO:0005044	scavenger receptor activity	Molecular Function		11
GO:0035529	NADH pyrophosphatase activity	Molecular Function		2
GO:0003676	nucleic acid binding	Molecular Function		41
GO:0009143	nucleoside triphosphate catabolic process	Biological Process	IDA[10513816]	3
GO:0004528	phosphodiesterase I activity	Molecular Function		3
GO:0030247	polysaccharide binding	Molecular Function		3
GO:0006796	phosphate-containing compound metabolic process	Biological Process	IDA[10513816]	3
GO:0006955	immune response	Biological Process		45
GO:0005576	extracellular region	Cellular Component		240
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9344668]	220

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in ADHDgene
hsa00230	Purine metabolism	22
hsa01100	Metabolic pathways	237
hsa00740	Riboflavin metabolism	4
hsa00770	Pantothenate and CoA biosynthesis	7
hsa00500	Starch and sucrose metabolism	26
hsa00760	Nicotinate and nicotinamide metabolism	9

Genes shared at least 5 GO terms with ENPP3 (count: 1)

Gene Symbol	Pathway Count	Pathway List
ENPP1	12	metal ion binding; nucleoside-triphosphate diphosphatase activity; nucleotide diphosphatase activity; inorganic diphosphate transport; scavenger receptor activity; NADH pyrophosphatase activity; nucleic acid binding; nucleoside triphosphate catabolic process; phosphodiesterase I activity; polysaccharide binding; phosphate-containing compound metabolic process; immune response;

Genes shared at least 2 KEGG pathways with ENPP3 (count: 43)

Gene Symbol	Pathway Count	Pathway List
ENPP1	6	Purine metabolism; Metabolic pathways; Riboflavin metabolism; Pantothenate and CoA biosynthesis; Starch and sucrose metabolism; Nicotinate and nicotinamide metabolism;
NT5M	3	Purine metabolism; Metabolic pathways; Nicotinate and nicotinamide metabolism;
APRT	2	Purine metabolism; Metabolic pathways;
ATIC	2	Purine metabolism; Metabolic pathways;
ITPA	2	Purine metabolism; Metabolic pathways;
POLA2	2	Purine metabolism; Metabolic pathways;
POLD3	2	Purine metabolism; Metabolic pathways;
POLD4	2	Purine metabolism; Metabolic pathways;
POLE	2	Purine metabolism; Metabolic pathways;
POLE3	2	Purine metabolism; Metabolic pathways;
POLR1A	2	Purine metabolism; Metabolic pathways;
POLR2G	2	Purine metabolism; Metabolic pathways;
RRM2	2	Purine metabolism; Metabolic pathways;
HK1	2	Metabolic pathways; Starch and sucrose metabolism;
HKDC1	2	Metabolic pathways; Starch and sucrose metabolism;
NADSYN1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NAPRT1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT2	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT3	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NNMT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
PANK2	2	Metabolic pathways; Pantothenate and CoA biosynthesis;
QPRT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
TYR	2	Metabolic pathways; Riboflavin metabolism;
UGT1A1	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A10	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A3	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A4	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A5	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A6	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A7	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A8	2	Metabolic pathways; Starch and sucrose metabolism;
UGT1A9	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2A1	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2A2	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2A3	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B10	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B11	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B15	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B17	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B28	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B4	2	Metabolic pathways; Starch and sucrose metabolism;
UGT2B7	2	Metabolic pathways; Starch and sucrose metabolism;
UPB1	2	Metabolic pathways; Pantothenate and CoA biosynthesis;

View in gBrowse

Region: chr6:131949582..132068553 View in gBrowse