ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ERN2
Symbol Alias	IRE1b
Approved Name	endoplasmic reticulum to nucleus signaling 2
Previous Name	ER to nucleus signalling 2
Location	16p12.2
Position	chr16:23701625-23724821, -
External Links	HGNC: 16942 Entrez Gene: 10595 Ensembl: ENSG00000134398 UCSC: uc002dma.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p12.3-12.2	chr16:16800000-24200000	1 (1/0/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005524	ATP binding	Molecular Function	IDA[11175748]	228
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[11175748]	61
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0006468	protein phosphorylation	Biological Process	IDA[11175748]	53
GO:0006397	mRNA processing	Biological Process		50
GO:0006917	induction of apoptosis	Biological Process	IMP[11175748]	31
GO:0006915	apoptotic process	Biological Process		111
GO:0007050	cell cycle arrest	Biological Process		25
GO:0006950	response to stress	Biological Process		30
GO:0016075	rRNA catabolic process	Biological Process	IDA[11175748]	2
GO:0016021	integral to membrane	Cellular Component		845
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IMP[11175748]	64
GO:0016891	endoribonuclease activity, producing 5'-phosphomonoesters	Molecular Function		2
GO:0000287	magnesium ion binding	Molecular Function	IDA[11175748]	28
GO:0004519	endonuclease activity	Molecular Function	IDA[11175748]	7

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ERN2 (count: 7)

Gene Symbol	Pathway Count	Pathway List
MAPK1	6	ATP binding; protein serine/threonine kinase activity; transcription, DNA-dependent; induction of apoptosis; apoptotic process; response to stress;
SGK1	6	ATP binding; protein serine/threonine kinase activity; endoplasmic reticulum membrane; protein phosphorylation; apoptotic process; response to stress;
TGFBR1	6	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; induction of apoptosis; apoptotic process; cell cycle arrest;
NEK6	5	ATP binding; protein serine/threonine kinase activity; protein phosphorylation; apoptotic process; magnesium ion binding;
PRKAA1	5	ATP binding; transcription, DNA-dependent; protein phosphorylation; cell cycle arrest; response to stress;
PRKCB	5	ATP binding; protein serine/threonine kinase activity; transcription, DNA-dependent; protein phosphorylation; apoptotic process;
TAOK2	5	ATP binding; protein serine/threonine kinase activity; apoptotic process; response to stress; integral to membrane;

Genes shared at least 2 KEGG pathways with ERN2 (count: 0)

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Region: chr16:23701625..23724821 View in gBrowse