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- Data Summary
Gene Report
Approved Symbol | ETS1 |
---|---|
Previous Symbol | EWSR2 |
Symbol Alias | FLJ10768, ETS-1 |
Approved Name | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) |
Previous Name | v-ets avian erythroblastosis virus E26 oncogene homolog 1 |
Name Alias | Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1, "ets protein" |
Location | 11q23.3 |
Position | chr11:128328656-128457453, - |
External Links |
HGNC: 3488 Entrez Gene: 2113 Ensembl: ENSG00000134954 UCSC: uc001qej.2 |
No. of Studies | 0 (significant: 0; non-significant: 0; trend: 0) |
Source | Mapped by significant region |
Region Name | Position | No. of Studies (significant/non-significant/trend) |
---|---|---|
11q | chr11:53700000-135006516 | 2 (1/1/0) |
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 35)
ID | Name | No. of Genes in ADHDgene | Brief Description |
---|---|---|---|
hsa05211 | Renal cell carcinoma | 13 | Renal cell cancer (RCC) accounts for ~3% of human malignanci...... Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer accounts for 1-4% of cases. RCC is not a single disease, it has several morphological subtypes. Conventional RCC (clear cell RCC) accounts for ~80% of cases, followed by papillary RCC (10-15%), chromophobe RCC (5%), and collecting duct RCC (<1%). Genes potentially involved in sporadic neoplasms of each particular type are VHL, MET, BHD, and FH respectively. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. Activated MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Loss of functional FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventional (clear cell) RCC. More... |
hsa04320 | Dorso-ventral axis formation | 6 | |
hsa05200 | Pathways in cancer | 52 |
Region: chr11:128328656..128457453 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014