ADHDgene Database

Gene Report

Basic Info

Approved Symbol	FAN1
Previous Symbol	KIAA1018, MTMR15
Approved Name	FANCD2/FANCI-associated nuclease 1
Previous Name	KIAA1018, "myotubularin related protein 15"
Location	15q13.2-q13.3
Position	chr15:31196055-31235311, +
External Links	HGNC: 29170 Entrez Gene: 22909 Ensembl: ENSG00000198690 UCSC: uc001zff.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_30	chr15:28797383-30302218 (NCBI36 / hg18)	1504836	15q13.2-15q13.3	dup

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
15q11.2-13.3	chr15:20700000-33600000	1 (1/0/0)
15q13.3	chr15:31200000-33600000	1 (1/0/0)

Gene related GO terms (count: 12)

ID	Name	Type	No. of Genes in ADHDgene
GO:0003677	DNA binding	Molecular Function	220
GO:0000724	double-strand break repair via homologous recombination	Biological Process	12
GO:0000287	magnesium ion binding	Molecular Function	28
GO:0043130	ubiquitin binding	Molecular Function	9
GO:0033683	nucleotide-excision repair, DNA incision	Biological Process	1
GO:0017108	5'-flap endonuclease activity	Molecular Function	3
GO:0008409	5'-3' exonuclease activity	Molecular Function	3
GO:0006289	nucleotide-excision repair	Biological Process	12
GO:0006281	DNA repair	Biological Process	62
GO:0005634	nucleus	Cellular Component	770
GO:0005515	protein binding	Molecular Function	910
GO:0004528	phosphodiesterase I activity	Molecular Function	3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FAN1 (count: 4)

Gene Symbol	Pathway Count	Pathway List
FEN1	7	DNA binding; magnesium ion binding; 5'-flap endonuclease activity; 5'-3' exonuclease activity; DNA repair; nucleus; protein binding;
DDB1	5	DNA binding; nucleotide-excision repair; DNA repair; nucleus; protein binding;
H2AFX	5	DNA binding; double-strand break repair via homologous recombination; DNA repair; nucleus; protein binding;
MRE11A	5	DNA binding; double-strand break repair via homologous recombination; DNA repair; nucleus; protein binding;

Genes shared at least 2 KEGG pathways with FAN1 (count: 0)

View in gBrowse

Region: chr15:31196055..31235311 View in gBrowse