ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOXC2
Previous Symbol	FKHL14
Symbol Alias	MFH-1
Approved Name	forkhead box C2 (MFH-1, mesenchyme forkhead 1)
Location	16q24.1
Position	chr16:86600857-86602539, +
External Links	HGNC: 3801 Entrez Gene: 2303 Ensembl: ENSG00000176692 UCSC: uc002fjq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 49)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 49)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050880	regulation of blood vessel size	Biological Process		2
GO:0048844	artery morphogenesis	Biological Process		9
GO:0048703	embryonic viscerocranium morphogenesis	Biological Process		5
GO:0048343	paraxial mesodermal cell fate commitment	Biological Process		1
GO:0048010	vascular endothelial growth factor receptor signaling pathway	Biological Process		6
GO:0046620	regulation of organ growth	Biological Process		3
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[9169153]	80
GO:0044212	transcription regulatory region DNA binding	Molecular Function		23
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA[16081467]	72
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0043010	camera-type eye development	Biological Process		6
GO:0035470	positive regulation of vascular wound healing	Biological Process		2
GO:0035050	embryonic heart tube development	Biological Process		3
GO:0033630	positive regulation of cell adhesion mediated by integrin	Biological Process		2
GO:0031490	chromatin DNA binding	Molecular Function	IDA[16456100]	1
GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	Biological Process		2
GO:0072112	glomerular visceral epithelial cell differentiation	Biological Process		1
GO:0072144	glomerular mesangial cell development	Biological Process		1
GO:0060038	cardiac muscle cell proliferation	Biological Process		1
GO:0072011	glomerular endothelium development	Biological Process		1
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process		16
GO:0055010	ventricular cardiac muscle tissue morphogenesis	Biological Process		2
GO:0001756	somitogenesis	Biological Process		7
GO:0001657	ureteric bud development	Biological Process		4
GO:0001974	blood vessel remodeling	Biological Process		7
GO:0001946	lymphangiogenesis	Biological Process	IMP[12114478]	4
GO:0001569	patterning of blood vessels	Biological Process		7
GO:0001503	ossification	Biological Process		9
GO:0001656	metanephros development	Biological Process		7
GO:0001570	vasculogenesis	Biological Process		10
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	Molecular Function		8
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0010595	positive regulation of endothelial cell migration	Biological Process		7
GO:0014032	neural crest cell development	Biological Process		3
GO:0014034	neural crest cell fate commitment	Biological Process		1
GO:0030199	collagen fibril organization	Biological Process		5
GO:0008134	transcription factor binding	Molecular Function		38
GO:0008286	insulin receptor signaling pathway	Biological Process	IDA[16456100]	32
GO:0008301	DNA binding, bending	Molecular Function		9
GO:0009725	response to hormone stimulus	Biological Process	IDA[16456100]	11
GO:0005667	transcription factor complex	Cellular Component		51
GO:0007219	Notch signaling pathway	Biological Process		21
GO:0007498	mesoderm development	Biological Process	NAS[8674414]	9
GO:0007507	heart development	Biological Process		23
GO:0003690	double-stranded DNA binding	Molecular Function		17
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[9169153]	132
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function		15
GO:0005634	nucleus	Cellular Component	IDA[16081467]	770

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FOXC2 (count: 56)

Gene Symbol	Pathway Count	Pathway List
FOXF1	15	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding; regulation of sequence-specific DNA binding transcription factor activity; somitogenesis; vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; DNA binding, bending; transcription factor complex; heart development; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
FOXE1	12	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; regulation of sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; DNA binding, bending; transcription factor complex; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
FOXL1	11	sequence-specific DNA binding; camera-type eye development; regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; DNA binding, bending; transcription factor complex; heart development; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
TBX1	10	artery morphogenesis; embryonic viscerocranium morphogenesis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; blood vessel remodeling; mesoderm development; heart development; sequence-specific DNA binding transcription factor activity; nucleus;
VEGFA	10	artery morphogenesis; vascular endothelial growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; positive regulation of cell migration involved in sprouting angiogenesis; patterning of blood vessels; vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell migration; mesoderm development;
FOXD4	10	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; DNA binding, bending; transcription factor complex; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
HNF1B	10	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
RELA	10	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding; negative regulation of apoptotic process; transcription factor binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
FOXG1	9	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; DNA binding, bending; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
FOXP1	9	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; DNA binding, bending; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
GATA6	9	positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
TFAP2A	9	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding; negative regulation of apoptotic process; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; negative regulation of transcription from RNA polymerase II promoter; neural crest cell development; nucleus;
FOXP2	9	sequence-specific DNA binding; camera-type eye development; regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; DNA binding, bending; transcription factor complex; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
HES1	8	artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; Notch signaling pathway; sequence-specific DNA binding transcription factor activity; nucleus;
HEY2	8	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; Notch signaling pathway; sequence-specific DNA binding transcription factor activity; nucleus;
KDM1A	8	positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; nucleus;
KLF4	8	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; negative regulation of transcription from RNA polymerase II promoter; transcription factor complex; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA13	7	artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; sequence-specific DNA binding; vasculogenesis; sequence-specific DNA binding transcription factor activity; nucleus;
ETS1	7	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; transcription factor binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; nucleus;
FGF10	7	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; blood vessel remodeling; metanephros development; insulin receptor signaling pathway; nucleus;
MED1	7	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; embryonic heart tube development; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; nucleus;
MTA2	7	positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor complex; sequence-specific DNA binding transcription factor activity; nucleus;
NCOR1	7	transcription regulatory region DNA binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor complex; Notch signaling pathway; sequence-specific DNA binding transcription factor activity; nucleus;
FOXR1	7	sequence-specific DNA binding; regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; DNA binding, bending; transcription factor complex; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
HOXA2	6	embryonic viscerocranium morphogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
LHX1	6	embryonic viscerocranium morphogenesis; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; ureteric bud development; sequence-specific DNA binding transcription factor activity; nucleus;
HOXA7	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding transcription factor activity; nucleus;
IKZF1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; mesoderm development; sequence-specific DNA binding transcription factor activity; nucleus;
LHX2	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; mesoderm development; sequence-specific DNA binding transcription factor activity; nucleus;
MEIS2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding transcription factor activity; nucleus;
MEN1	6	positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; double-stranded DNA binding; nucleus;
NCOA6	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to hormone stimulus; transcription factor complex; heart development; nucleus;
RBPJ	6	positive regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; sequence-specific DNA binding transcription factor activity; nucleus;
SREBF1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; insulin receptor signaling pathway; sequence-specific DNA binding transcription factor activity; nucleus;
YAP1	6	positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; negative regulation of apoptotic process; vasculogenesis; transcription factor complex; nucleus;
HOXA1	5	artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
TGFBR1	5	artery morphogenesis; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; collagen fibril organization; heart development;
FLT4	5	vascular endothelial growth factor receptor signaling pathway; negative regulation of apoptotic process; lymphangiogenesis; positive regulation of endothelial cell migration; nucleus;
ARRB1	5	positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; transcription factor binding; Notch signaling pathway; nucleus;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; nucleus;
ISL1	5	positive regulation of transcription from RNA polymerase II promoter; ventricular cardiac muscle tissue morphogenesis; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
KAT5	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus;
MAF	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
MLL	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
NR5A1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus;
POU2F3	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; nucleus;
SPI1	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
TCF21	5	positive regulation of transcription from RNA polymerase II promoter; ureteric bud development; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; negative regulation of transcription from RNA polymerase II promoter; nucleus;
TFEB	5	positive regulation of transcription from RNA polymerase II promoter; transcription regulatory region DNA binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; nucleus;
CREB5	5	positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific DNA binding transcription factor activity; nucleus;
FEV	5	positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
HMGA1	5	positive regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; nucleus;
HOXA11	5	positive regulation of transcription, DNA-dependent; sequence-specific DNA binding; metanephros development; transcription factor complex; sequence-specific DNA binding transcription factor activity;
MAPK1	5	positive regulation of transcription, DNA-dependent; regulation of sequence-specific DNA binding transcription factor activity; transcription factor binding; insulin receptor signaling pathway; nucleus;
DRAP1	5	sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; sequence-specific DNA binding transcription factor activity; nucleus;
IRX3	5	sequence-specific DNA binding; metanephros development; mesoderm development; sequence-specific DNA binding transcription factor activity; nucleus;

Genes shared at least 2 KEGG pathways with FOXC2 (count: 0)

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Region: chr16:86600857..86602539 View in gBrowse