ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOXE1
Previous Symbol	FKHL15, TITF2, FOXE2
Symbol Alias	TTF-2, HFKH4
Approved Name	forkhead box E1 (thyroid transcription factor 2)
Previous Name	forkhead box E2
Location	9q22
Position	chr9:100615537-100618997, +
External Links	HGNC: 3806 Entrez Gene: 2304 Ensembl: ENSG00000178919 UCSC: uc004axu.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 31)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 31)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048846	axon extension involved in axon guidance	Biological Process		3
GO:0048562	embryonic organ morphogenesis	Biological Process		1
GO:0048538	thymus development	Biological Process	IEP[15494458]	14
GO:0048485	sympathetic nervous system development	Biological Process		5
GO:0060023	soft palate development	Biological Process	IMP[12165566]	2
GO:0060022	hard palate development	Biological Process	IMP[12165566]	1
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process		16
GO:0048937	lateral line nerve glial cell development	Biological Process		2
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0031069	hair follicle morphogenesis	Biological Process		4
GO:0030878	thyroid gland development	Biological Process	IEP[15494458]; IMP[9697705]	7
GO:0016477	cell migration	Biological Process		24
GO:0048484	enteric nervous system development	Biological Process		4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[9697705]	80
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process		64
GO:0060465	pharynx development	Biological Process	IEP[15494458]	1
GO:0005634	nucleus	Cellular Component	IDA[9697705]	770
GO:0005667	transcription factor complex	Cellular Component		51
GO:0006590	thyroid hormone generation	Biological Process		5
GO:0007389	pattern specification process	Biological Process		13
GO:0007422	peripheral nervous system development	Biological Process		7
GO:0008134	transcription factor binding	Molecular Function		38
GO:0008301	DNA binding, bending	Molecular Function		9
GO:0009653	anatomical structure morphogenesis	Biological Process	NAS[9169137]	26
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	NAS[9169137]	78
GO:0002089	lens morphogenesis in camera-type eye	Biological Process		3
GO:0003677	DNA binding	Molecular Function	IDA[9697705]	220
GO:0003690	double-stranded DNA binding	Molecular Function		17
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[9697705]	132
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function		15

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FOXE1 (count: 59)

Gene Symbol	Pathway Count	Pathway List
FOXD4	16	axon extension involved in axon guidance; sympathetic nervous system development; regulation of sequence-specific DNA binding transcription factor activity; lateral line nerve glial cell development; sequence-specific DNA binding; enteric nervous system development; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; pattern specification process; peripheral nervous system development; transcription factor binding; DNA binding, bending; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXF1	13	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; transcription factor complex; pattern specification process; transcription factor binding; DNA binding, bending; negative regulation of transcription from RNA polymerase II promoter; DNA binding; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXC2	12	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; transcription factor complex; transcription factor binding; DNA binding, bending; negative regulation of transcription from RNA polymerase II promoter; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXG1	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; transcription factor complex; transcription factor binding; DNA binding, bending; DNA binding; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXL1	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; nucleus; transcription factor complex; pattern specification process; transcription factor binding; DNA binding, bending; DNA binding; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXP1	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; transcription factor complex; pattern specification process; transcription factor binding; DNA binding, bending; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXP2	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; negative regulation of transcription, DNA-dependent; transcription factor complex; pattern specification process; transcription factor binding; DNA binding, bending; DNA binding; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
HES1	10	thymus development; sequence-specific DNA binding; cell migration; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
TBX1	10	thymus development; soft palate development; sequence-specific DNA binding; thyroid gland development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; pattern specification process; DNA binding; sequence-specific DNA binding transcription factor activity;
RELA	10	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; transcription factor complex; transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
HNF1B	9	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; transcription factor complex; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
FOXR1	8	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; transcription factor complex; pattern specification process; transcription factor binding; DNA binding, bending; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
ETS1	8	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; transcription factor complex; transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity;
GATA6	8	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; transcription factor complex; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
IKZF1	7	thymus development; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
MYB	7	thymus development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
TFAP2A	7	sympathetic nervous system development; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter;
HEY2	7	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
HOXA5	7	sequence-specific DNA binding; thyroid gland development; cell migration; positive regulation of transcription from RNA polymerase II promoter; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA7	7	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
LHX1	7	sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; pattern specification process; anatomical structure morphogenesis; sequence-specific DNA binding transcription factor activity;
KDM1A	7	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; transcription factor complex; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
KLF4	7	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; transcription factor complex; negative regulation of transcription from RNA polymerase II promoter; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity;
HMGA1	7	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; transcription factor complex; transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity;
FGF10	6	thymus development; hair follicle morphogenesis; thyroid gland development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus;
CREBZF	6	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; negative regulation of transcription, DNA-dependent; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity;
DRAP1	6	sequence-specific DNA binding; nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
HOXB1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; pattern specification process; DNA binding; sequence-specific DNA binding transcription factor activity;
MEIS2	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
MEN1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; double-stranded DNA binding;
MTA2	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
NR5A1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; DNA binding; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
SREBF1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
KAT5	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; transcription factor complex; negative regulation of transcription from RNA polymerase II promoter;
MED1	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; thyroid hormone generation; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter;
RBPJ	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
SPI1	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
HOXA3	5	thymus development; sequence-specific DNA binding; thyroid gland development; nucleus; sequence-specific DNA binding transcription factor activity;
LMO4	5	thymus development; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; transcription factor binding; sequence-specific DNA binding transcription factor activity;
MAPK1	5	regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; nucleus; transcription factor binding; DNA binding;
BSX	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity;
FEV	5	sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; nucleus; double-stranded DNA binding; sequence-specific DNA binding transcription factor activity;
GSC2	5	sequence-specific DNA binding; nucleus; anatomical structure morphogenesis; DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA1	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; anatomical structure morphogenesis; sequence-specific DNA binding transcription factor activity;
HOXA11	5	sequence-specific DNA binding; positive regulation of transcription, DNA-dependent; transcription factor complex; anatomical structure morphogenesis; sequence-specific DNA binding transcription factor activity;
HOXA13	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity;
HOXA2	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
LHX2	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
MAF	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
NCOR1	5	sequence-specific DNA binding; nucleus; transcription factor complex; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
POU2F3	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity;
ZNF24	5	sequence-specific DNA binding; negative regulation of transcription, DNA-dependent; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity;
BARX2	5	positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;
E2F5	5	positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; transcription factor binding; DNA binding; sequence-specific DNA binding transcription factor activity;
IRF7	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; DNA binding;
STRN3	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
HINFP	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity;
RREB1	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; DNA binding; sequence-specific DNA binding transcription factor activity;
TBX6	5	nucleus; anatomical structure morphogenesis; negative regulation of transcription from RNA polymerase II promoter; DNA binding; sequence-specific DNA binding transcription factor activity;

Genes shared at least 2 KEGG pathways with FOXE1 (count: 0)

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Region: chr9:100615537..100618997 View in gBrowse