ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOXF1
Previous Symbol	FKHL5
Symbol Alias	FREAC1
Approved Name	forkhead box F1
Location	16q24
Position	chr16:86544133-86548076, +
External Links	HGNC: 3809 Entrez Gene: 2294 Ensembl: ENSG00000103241 UCSC: uc002fjl.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 60)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 60)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048617	embryonic foregut morphogenesis	Biological Process		1
GO:0048613	embryonic ectodermal digestive tract morphogenesis	Biological Process	IMP[19500772]	1
GO:0048565	digestive tract development	Biological Process	IMP[19500772]	2
GO:0048557	embryonic digestive tract morphogenesis	Biological Process	IMP[19500772]	7
GO:0051150	regulation of smooth muscle cell differentiation	Biological Process		1
GO:0051145	smooth muscle cell differentiation	Biological Process		6
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process		16
GO:0050728	negative regulation of inflammatory response	Biological Process		11
GO:0045198	establishment of epithelial cell apical/basal polarity	Biological Process		1
GO:0044212	transcription regulatory region DNA binding	Molecular Function		23
GO:0043565	sequence-specific DNA binding	Molecular Function	ISS[7957066]	72
GO:0043305	negative regulation of mast cell degranulation	Biological Process		1
GO:0048371	lateral mesodermal cell differentiation	Biological Process		1
GO:0048286	lung alveolus development	Biological Process		5
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[9769171]	80
GO:0003677	DNA binding	Molecular Function	IDA[9769171]	220
GO:0016337	cell-cell adhesion	Biological Process		13
GO:0003690	double-stranded DNA binding	Molecular Function		17
GO:0030198	extracellular matrix organization	Biological Process		31
GO:0010811	positive regulation of cell-substrate adhesion	Biological Process		6
GO:0003197	endocardial cushion development	Biological Process	IMP[19500772]	1
GO:0014822	detection of wounding	Biological Process		1
GO:0003214	cardiac left ventricle morphogenesis	Biological Process	IMP[19500772]	3
GO:0005667	transcription factor complex	Cellular Component		51
GO:0030335	positive regulation of cell migration	Biological Process		29
GO:0007224	smoothened signaling pathway	Biological Process		10
GO:0031016	pancreas development	Biological Process	IMP[19500772]	5
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function		15
GO:0030323	respiratory tube development	Biological Process	IMP[19500772]	1
GO:0005634	nucleus	Cellular Component	IC[9769171]	770
GO:0030324	lung development	Biological Process	IMP[19500772]	12
GO:0007494	midgut development	Biological Process	IMP[19500772]	1
GO:0001568	blood vessel development	Biological Process	IMP[19500772]	5
GO:0007507	heart development	Biological Process	IMP[19500772]	23
GO:0001570	vasculogenesis	Biological Process		10
GO:0007368	determination of left/right symmetry	Biological Process		7
GO:0007389	pattern specification process	Biological Process		13
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0009790	embryo development	Biological Process		17
GO:0001763	morphogenesis of a branching structure	Biological Process	IMP[19500772]	3
GO:0009888	tissue development	Biological Process		4
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process		9
GO:0008134	transcription factor binding	Molecular Function		38
GO:0001701	in utero embryonic development	Biological Process	IMP[19500772]	32
GO:0008301	DNA binding, bending	Molecular Function		9
GO:0001756	somitogenesis	Biological Process		7
GO:0071345	cellular response to cytokine stimulus	Biological Process		1
GO:0071407	cellular response to organic cyclic compound	Biological Process		4
GO:0072001	renal system development	Biological Process	IMP[19500772]	2
GO:0072189	ureter development	Biological Process	IMP[19500772]	1
GO:0090131	mesenchyme migration	Biological Process		1
GO:0060426	lung vasculature development	Biological Process	IMP[19500772]	3
GO:0060438	trachea development	Biological Process		1
GO:0060441	epithelial tube branching involved in lung morphogenesis	Biological Process		2
GO:0060446	branching involved in open tracheal system development	Biological Process	IMP[19500772]	1
GO:0060461	right lung morphogenesis	Biological Process		1
GO:0060463	lung lobe morphogenesis	Biological Process		1
GO:0060841	venous blood vessel development	Biological Process	IMP[19500772]	1
GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development	Biological Process		2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FOXF1 (count: 47)

Gene Symbol	Pathway Count	Pathway List
FOXC2	15	regulation of sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; double-stranded DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; heart development; vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; DNA binding, bending; somitogenesis;
FOXP1	14	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; double-stranded DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; lung development; pattern specification process; embryo development; positive regulation of mesenchymal cell proliferation; transcription factor binding; in utero embryonic development; DNA binding, bending;
FOXE1	13	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; DNA binding; double-stranded DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; pattern specification process; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; DNA binding, bending;
FOXL1	12	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding; double-stranded DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; heart development; pattern specification process; embryo development; transcription factor binding; DNA binding, bending;
FOXP2	12	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; lung alveolus development; DNA binding; double-stranded DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; pattern specification process; embryo development; positive regulation of mesenchymal cell proliferation; transcription factor binding; DNA binding, bending;
FOXD4	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; double-stranded DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; pattern specification process; embryo development; transcription factor binding; DNA binding, bending;
FOXG1	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; DNA binding; double-stranded DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; tissue development; transcription factor binding; DNA binding, bending;
HNF1B	10	embryonic digestive tract morphogenesis; transcription regulatory region DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter;
FOXR1	10	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; double-stranded DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; pattern specification process; embryo development; tissue development; transcription factor binding; DNA binding, bending;
TBX1	10	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; DNA binding; nucleus; blood vessel development; heart development; determination of left/right symmetry; pattern specification process; positive regulation of mesenchymal cell proliferation;
GATA6	9	smooth muscle cell differentiation; transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; in utero embryonic development;
RELA	9	transcription regulatory region DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; DNA binding; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding;
HEY2	8	smooth muscle cell differentiation; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; cardiac left ventricle morphogenesis; nucleus; vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding;
ETS1	8	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; DNA binding; transcription factor complex; positive regulation of cell migration; nucleus; transcription factor binding;
HES1	8	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; DNA binding; smoothened signaling pathway; nucleus; lung development; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding;
FGF10	7	embryonic digestive tract morphogenesis; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; pancreas development; nucleus; determination of left/right symmetry;
TCF21	7	embryonic digestive tract morphogenesis; lung alveolus development; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; morphogenesis of a branching structure; lung vasculature development;
KLF4	7	negative regulation of inflammatory response; transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; double-stranded DNA binding; transcription factor complex; negative regulation of transcription from RNA polymerase II promoter;
KDM1A	7	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; in utero embryonic development;
TFAP2A	7	transcription regulatory region DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of cell migration; nucleus; negative regulation of transcription from RNA polymerase II promoter;
NR5A1	7	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; DNA binding; double-stranded DNA binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; nucleus; tissue development;
VEGFA	7	positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell migration; lung development; vasculogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mesenchymal cell proliferation; in utero embryonic development;
IHH	6	embryonic digestive tract morphogenesis; positive regulation of transcription from RNA polymerase II promoter; smoothened signaling pathway; pancreas development; positive regulation of mesenchymal cell proliferation; in utero embryonic development;
MAPK1	6	regulation of sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; DNA binding; positive regulation of cell migration; nucleus; transcription factor binding;
HOXA13	6	transcription regulatory region DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; vasculogenesis;
MEN1	6	transcription regulatory region DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; double-stranded DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MTA2	6	transcription regulatory region DNA binding; sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus; negative regulation of transcription from RNA polymerase II promoter;
HOXA5	6	sequence-specific DNA binding; lung alveolus development; positive regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; epithelial tube branching involved in lung morphogenesis;
SREBF1	6	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; lung development; negative regulation of transcription from RNA polymerase II promoter;
ID2	5	embryonic digestive tract morphogenesis; positive regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; epithelial cell differentiation involved in mammary gland alveolus development;
NFATC4	5	smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; DNA binding; transcription factor complex; heart development;
ISL1	5	negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; pancreas development; nucleus; negative regulation of transcription from RNA polymerase II promoter;
HINFP	5	transcription regulatory region DNA binding; positive regulation of transcription, DNA-dependent; DNA binding; nucleus; in utero embryonic development;
NCOR1	5	transcription regulatory region DNA binding; sequence-specific DNA binding; transcription factor complex; nucleus; negative regulation of transcription from RNA polymerase II promoter;
YAP1	5	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus; vasculogenesis;
DRAP1	5	sequence-specific DNA binding; DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding;
HOXA7	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding;
HOXB1	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; pattern specification process;
IKZF1	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MEIS2	5	sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding;
IRF7	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
KAT5	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription factor complex; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MED1	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding;
MYB	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; DNA binding; negative regulation of transcription from RNA polymerase II promoter; in utero embryonic development;
NCOA6	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription factor complex; nucleus; heart development;
RBPJ	5	positive regulation of transcription from RNA polymerase II promoter; DNA binding; cardiac left ventricle morphogenesis; nucleus; negative regulation of transcription from RNA polymerase II promoter;
HMGA1	5	positive regulation of transcription, DNA-dependent; DNA binding; transcription factor complex; nucleus; transcription factor binding;

Genes shared at least 2 KEGG pathways with FOXF1 (count: 0)

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Region: chr16:86544133..86548076 View in gBrowse