ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FOXL1
Previous Symbol	FKHL11
Symbol Alias	FREAC7, FKH6
Approved Name	forkhead box L1
Location	16q24
Position	chr16:86612115-86615304, +
External Links	HGNC: 3817 Entrez Gene: 2300 Ensembl: ENSG00000176678 UCSC: uc002fjr.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	Biological Process		16
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA[7957066]	72
GO:0043010	camera-type eye development	Biological Process		6
GO:0035136	forelimb morphogenesis	Biological Process		4
GO:0030166	proteoglycan biosynthetic process	Biological Process		3
GO:0030111	regulation of Wnt receptor signaling pathway	Biological Process		2
GO:0009887	organ morphogenesis	Biological Process		19
GO:0009790	embryo development	Biological Process		17
GO:0008301	DNA binding, bending	Molecular Function	NAS[7957066]	9
GO:0008134	transcription factor binding	Molecular Function		38
GO:0007507	heart development	Biological Process		23
GO:0007495	visceral mesoderm-endoderm interaction involved in midgut development	Biological Process		1
GO:0007420	brain development	Biological Process		33
GO:0007389	pattern specification process	Biological Process		13
GO:0007275	multicellular organismal development	Biological Process	NAS[11078474]	71
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0005634	nucleus	Cellular Component	IC[7957066]	770
GO:0005667	transcription factor complex	Cellular Component		51
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function		15
GO:0003677	DNA binding	Molecular Function	IDA[7957066]	220
GO:0003690	double-stranded DNA binding	Molecular Function		17
GO:0051216	cartilage development	Biological Process		11

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with FOXL1 (count: 27)

Gene Symbol	Pathway Count	Pathway List
FOXD4	14	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; embryo development; DNA binding, bending; transcription factor binding; pattern specification process; multicellular organismal development; regulation of transcription, DNA-dependent; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding; cartilage development;
FOXF1	12	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; embryo development; DNA binding, bending; transcription factor binding; heart development; pattern specification process; nucleus; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; double-stranded DNA binding;
FOXP2	12	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; camera-type eye development; embryo development; DNA binding, bending; transcription factor binding; pattern specification process; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; double-stranded DNA binding;
FOXC2	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; camera-type eye development; DNA binding, bending; transcription factor binding; heart development; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding;
FOXE1	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; pattern specification process; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; double-stranded DNA binding;
FOXG1	11	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; DNA binding, bending; transcription factor binding; brain development; regulation of transcription, DNA-dependent; nucleus; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; double-stranded DNA binding;
FOXP1	10	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; embryo development; DNA binding, bending; transcription factor binding; pattern specification process; nucleus; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding;
FOXR1	9	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; embryo development; DNA binding, bending; transcription factor binding; pattern specification process; transcription factor complex; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; double-stranded DNA binding;
RELA	8	sequence-specific DNA binding; organ morphogenesis; transcription factor binding; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding;
HNF1B	7	sequence-specific DNA binding; regulation of Wnt receptor signaling pathway; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding;
HOXB1	7	sequence-specific DNA binding; pattern specification process; multicellular organismal development; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ETS1	6	sequence-specific DNA binding; transcription factor binding; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity; DNA binding;
TBX1	6	sequence-specific DNA binding; heart development; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HMGA1	6	transcription factor binding; regulation of transcription, DNA-dependent; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity; DNA binding;
CREBZF	5	regulation of sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
MAPK1	5	regulation of sequence-specific DNA binding transcription factor activity; organ morphogenesis; transcription factor binding; nucleus; DNA binding;
DRAP1	5	sequence-specific DNA binding; transcription factor binding; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HES1	5	sequence-specific DNA binding; transcription factor binding; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
HOXA9	5	sequence-specific DNA binding; multicellular organismal development; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity;
LHX1	5	sequence-specific DNA binding; organ morphogenesis; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity;
LMX1B	5	sequence-specific DNA binding; multicellular organismal development; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
NR5A1	5	sequence-specific DNA binding; nucleus; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; double-stranded DNA binding;
RAX	5	sequence-specific DNA binding; camera-type eye development; pattern specification process; nucleus; sequence-specific DNA binding transcription factor activity;
E2F5	5	organ morphogenesis; transcription factor binding; transcription factor complex; sequence-specific DNA binding transcription factor activity; DNA binding;
GATA6	5	transcription factor binding; nucleus; transcription factor complex; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
HES6	5	transcription factor binding; regulation of transcription, DNA-dependent; transcription factor complex; sequence-specific DNA binding transcription factor activity; DNA binding;
RREB1	5	multicellular organismal development; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;

Genes shared at least 2 KEGG pathways with FOXL1 (count: 0)

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Region: chr16:86612115..86615304 View in gBrowse