ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	FZD4
Previous Symbol	EVR1
Symbol Alias	CD344
Approved Name	frizzled family receptor 4
Previous Name	frizzled (Drosophila) homolog 4, "exudative vitreoretinopathy 1", "frizzled homolog 4 (Drosophila)", "frizzled 4, seven transmembrane spanning receptor"
Location	11q14-q21
Position	chr11:86656721-86666433, -
External Links	HGNC: 4042 Entrez Gene: 8322 Ensembl: ENSG00000174804 UCSC: uc001pce.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 36)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 36)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009790	embryo development	Biological Process		17
GO:0009986	cell surface	Cellular Component	IDA[19643732]	70
GO:0010812	negative regulation of cell-substrate adhesion	Biological Process	IMP[18156211]	1
GO:0016055	Wnt receptor signaling pathway	Biological Process	IDA[17955262]	20
GO:0005911	cell-cell junction	Cellular Component		20
GO:0007223	Wnt receptor signaling pathway, calcium modulating pathway	Biological Process	IDA[12172548]	2
GO:0007420	brain development	Biological Process		33
GO:0007605	sensory perception of sound	Biological Process		31
GO:0005515	protein binding	Molecular Function		910
GO:0005737	cytoplasm	Cellular Component		690
GO:0005886	plasma membrane	Cellular Component	IDA[12172548]	772
GO:0005887	integral to plasma membrane	Cellular Component	IC[17955262]	220
GO:0001570	vasculogenesis	Biological Process		10
GO:0004930	G-protein coupled receptor activity	Molecular Function		236
GO:0043507	positive regulation of JUN kinase activity	Biological Process		6
GO:0042995	cell projection	Cellular Component		12
GO:0046982	protein heterodimerization activity	Molecular Function	IPI[14688793]	68
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[17955262]	80
GO:0042701	progesterone secretion	Biological Process		1
GO:0035426	extracellular matrix-cell signaling	Biological Process		1
GO:0042813	Wnt-activated receptor activity	Molecular Function	IDA[17955262]	2
GO:0042803	protein homodimerization activity	Molecular Function	IPI[14688793]	113
GO:0031625	ubiquitin protein ligase binding	Molecular Function		23
GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	Biological Process		1
GO:0034446	substrate adhesion-dependent cell spreading	Biological Process		4
GO:0031987	locomotion involved in locomotory behavior	Biological Process		1
GO:0019955	cytokine binding	Molecular Function	IPI[17955262]	4
GO:0017147	Wnt-protein binding	Molecular Function		3
GO:0030182	neuron differentiation	Biological Process		9
GO:0030165	PDZ domain binding	Molecular Function	IPI[19388021]	13
GO:0061304	retinal blood vessel morphogenesis	Biological Process		2
GO:0071300	cellular response to retinoic acid	Biological Process		7
GO:0061299	retina vasculature morphogenesis in camera-type eye	Biological Process	IMP[15024691]	1
GO:0061301	cerebellum vasculature morphogenesis	Biological Process		1
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity	Biological Process	IDA[14688793]	11
GO:0060070	canonical Wnt receptor signaling pathway	Biological Process	IDA[15035989]	13

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05217	Basal cell carcinoma	8	Cancer of the skin is the most common cancer in Caucasians a...... Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC. More...
hsa04310	Wnt signaling pathway	22	Wnt proteins are secreted morphogens that are required for b...... Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin. More...
hsa05200	Pathways in cancer	52
hsa04916	Melanogenesis	15	Cutaneous melanin pigment plays a critical role in camouflag...... Cutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory control by multiple agents. The most important positive regulator of melanogenesis is the MC1 receptor with its ligands melanocortic peptides. MC1R activates the cyclic AMP (cAMP) response-element binding protein (CREB). Increased expression of MITF and its activation by phosphorylation (P) stimulate the transcription of tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), which produce melanin. Melanin synthesis takes place within specialized intracellular organelles named melanosomes. Melanin-containing melanosomes then move from the perinuclear region to the dendrite tips and are transferred to keratinocytes by a still not well-characterized mechanism. More...

Genes shared at least 5 GO terms with FZD4 (count: 30)

Gene Symbol	Pathway Count	Pathway List
LRP5	8	Wnt receptor signaling pathway; protein binding; plasma membrane; positive regulation of transcription, DNA-dependent; Wnt-activated receptor activity; Wnt-protein binding; retinal blood vessel morphogenesis; canonical Wnt receptor signaling pathway;
ADAM17	7	cell surface; cell-cell junction; protein binding; cytoplasm; plasma membrane; integral to plasma membrane; PDZ domain binding;
LPAR1	6	cell surface; protein binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor activity; PDZ domain binding;
PTPRJ	6	cell surface; cell-cell junction; protein binding; plasma membrane; integral to plasma membrane; vasculogenesis;
VEGFA	6	cell surface; protein binding; cytoplasm; vasculogenesis; protein heterodimerization activity; protein homodimerization activity;
WNT6	6	cell surface; plasma membrane; positive regulation of transcription, DNA-dependent; neuron differentiation; cellular response to retinoic acid; canonical Wnt receptor signaling pathway;
CADM1	6	cell-cell junction; brain development; protein binding; plasma membrane; protein homodimerization activity; PDZ domain binding;
ILK	6	cell-cell junction; protein binding; cytoplasm; plasma membrane; positive regulation of transcription, DNA-dependent; substrate adhesion-dependent cell spreading;
ADRA2A	6	protein binding; cytoplasm; plasma membrane; integral to plasma membrane; protein heterodimerization activity; protein homodimerization activity;
ADRA2C	6	protein binding; cytoplasm; plasma membrane; integral to plasma membrane; protein heterodimerization activity; protein homodimerization activity;
ADRB1	6	protein binding; cytoplasm; plasma membrane; integral to plasma membrane; protein heterodimerization activity; PDZ domain binding;
WNT11	6	cytoplasm; plasma membrane; positive regulation of transcription, DNA-dependent; neuron differentiation; cellular response to retinoic acid; canonical Wnt receptor signaling pathway;
ADAM8	5	cell surface; protein binding; cytoplasm; plasma membrane; integral to plasma membrane;
CCR5	5	cell surface; protein binding; cytoplasm; plasma membrane; integral to plasma membrane;
CRYAB	5	cell surface; protein binding; cytoplasm; plasma membrane; protein homodimerization activity;
GHR	5	cell surface; protein binding; plasma membrane; integral to plasma membrane; protein homodimerization activity;
NTRK2	5	cell surface; integral to plasma membrane; vasculogenesis; protein homodimerization activity; neuron differentiation;
SCARB1	5	cell surface; cytoplasm; plasma membrane; integral to plasma membrane; protein homodimerization activity;
CTNND1	5	Wnt receptor signaling pathway; cell-cell junction; protein binding; cytoplasm; plasma membrane;
AQP4	5	cell-cell junction; sensory perception of sound; cytoplasm; plasma membrane; integral to plasma membrane;
PAK1	5	cell-cell junction; protein binding; cytoplasm; plasma membrane; positive regulation of JUN kinase activity;
PRKD1	5	cell-cell junction; protein binding; cytoplasm; plasma membrane; integral to plasma membrane;
ROR2	5	Wnt receptor signaling pathway, calcium modulating pathway; protein binding; integral to plasma membrane; positive regulation of transcription, DNA-dependent; Wnt-protein binding;
ARRB2	5	brain development; protein binding; cytoplasm; plasma membrane; ubiquitin protein ligase binding;
PAFAH1B2	5	brain development; cytoplasm; plasma membrane; protein heterodimerization activity; protein homodimerization activity;
TFAP2A	5	sensory perception of sound; protein binding; cytoplasm; positive regulation of transcription, DNA-dependent; protein homodimerization activity;
GSK3B	5	protein binding; cytoplasm; plasma membrane; ubiquitin protein ligase binding; canonical Wnt receptor signaling pathway;
MC1R	5	protein binding; cytoplasm; plasma membrane; integral to plasma membrane; ubiquitin protein ligase binding;
RNF40	5	protein binding; cytoplasm; plasma membrane; protein homodimerization activity; ubiquitin protein ligase binding;
SLC6A4	5	protein binding; plasma membrane; integral to plasma membrane; protein homodimerization activity; cellular response to retinoic acid;

Genes shared at least 2 KEGG pathways with FZD4 (count: 15)

Gene Symbol	Pathway Count	Pathway List
GSK3B	4	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer; Melanogenesis;
WNT10A	4	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer; Melanogenesis;
WNT11	4	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer; Melanogenesis;
WNT6	4	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer; Melanogenesis;
APC	3	Basal cell carcinoma; Wnt signaling pathway; Pathways in cancer;
PRKCB	3	Wnt signaling pathway; Pathways in cancer; Melanogenesis;
PTCH1	2	Basal cell carcinoma; Pathways in cancer;
STK36	2	Basal cell carcinoma; Pathways in cancer;
CAMK2D	2	Wnt signaling pathway; Melanogenesis;
CCND1	2	Wnt signaling pathway; Pathways in cancer;
MAPK9	2	Wnt signaling pathway; Pathways in cancer;
PLCB2	2	Wnt signaling pathway; Melanogenesis;
PLCB3	2	Wnt signaling pathway; Melanogenesis;
MAPK1	2	Pathways in cancer; Melanogenesis;
MAPK3	2	Pathways in cancer; Melanogenesis;

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Region: chr11:86656721..86666433 View in gBrowse