ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GABRA5
Approved Name	gamma-aminobutyric acid (GABA) A receptor, alpha 5
Location	15q11-q13
Position	chr15:27111866-27194357, +
External Links	HGNC: 4079 Entrez Gene: 2558 Ensembl: ENSG00000186297 UCSC: uc001zbd.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_46	chr15:21016722-25902239 (NCBI Build 36.1 (hg18))	4933636	15q11.2-15q13.1	Gain

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
15q11.2-13.3	chr15:20700000-33600000	1 (1/0/0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004890	GABA-A receptor activity	Molecular Function		4
GO:0004872	receptor activity	Molecular Function	TAS[1321750]	36
GO:0001662	behavioral fear response	Biological Process		7
GO:0005886	plasma membrane	Cellular Component		772
GO:0005254	chloride channel activity	Molecular Function		6
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function		7
GO:0005215	transporter activity	Molecular Function	TAS[1321750]	41
GO:0007214	gamma-aminobutyric acid signaling pathway	Biological Process		5
GO:0007165	signal transduction	Biological Process	TAS[1321750]	171
GO:0006810	transport	Biological Process	TAS[1321750]	62
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1321750]	220
GO:0007605	sensory perception of sound	Biological Process		31
GO:0008306	associative learning	Biological Process		5
GO:0007268	synaptic transmission	Biological Process		96
GO:0007420	brain development	Biological Process		33
GO:0032809	neuronal cell body membrane	Cellular Component		1
GO:0034220	ion transmembrane transport	Biological Process		11
GO:0030054	cell junction	Cellular Component		77
GO:0030425	dendrite	Cellular Component		46
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0050811	GABA receptor binding	Molecular Function		3
GO:0034707	chloride channel complex	Cellular Component		7
GO:0043235	receptor complex	Cellular Component		11
GO:0060384	innervation	Biological Process		3
GO:0090102	cochlea development	Biological Process		5
GO:0055085	transmembrane transport	Biological Process		82
GO:0060119	inner ear receptor cell development	Biological Process		2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93

Genes shared at least 5 GO terms with GABRA5 (count: 31)

Gene Symbol	Pathway Count	Pathway List
GABRB3	17	GABA-A receptor activity; plasma membrane; chloride channel activity; extracellular ligand-gated ion channel activity; signal transduction; transport; integral to plasma membrane; sensory perception of sound; synaptic transmission; ion transmembrane transport; cell junction; postsynaptic membrane; chloride channel complex; innervation; cochlea development; transmembrane transport; inner ear receptor cell development;
GABRG1	11	GABA-A receptor activity; plasma membrane; chloride channel activity; extracellular ligand-gated ion channel activity; gamma-aminobutyric acid signaling pathway; synaptic transmission; cell junction; postsynaptic membrane; GABA receptor binding; chloride channel complex; receptor complex;
GABRG3	11	GABA-A receptor activity; plasma membrane; chloride channel activity; extracellular ligand-gated ion channel activity; gamma-aminobutyric acid signaling pathway; synaptic transmission; ion transmembrane transport; cell junction; postsynaptic membrane; chloride channel complex; transmembrane transport;
HTR3A	10	receptor activity; plasma membrane; extracellular ligand-gated ion channel activity; transport; integral to plasma membrane; synaptic transmission; ion transmembrane transport; cell junction; postsynaptic membrane; transmembrane transport;
CHRM3	7	receptor activity; plasma membrane; signal transduction; integral to plasma membrane; cell junction; dendrite; postsynaptic membrane;
GRIN2B	7	behavioral fear response; plasma membrane; transport; integral to plasma membrane; synaptic transmission; cell junction; postsynaptic membrane;
GRM7	7	behavioral fear response; plasma membrane; integral to plasma membrane; sensory perception of sound; synaptic transmission; dendrite; postsynaptic membrane;
GRIK1	7	plasma membrane; transport; integral to plasma membrane; synaptic transmission; cell junction; dendrite; postsynaptic membrane;
HTR3B	7	plasma membrane; transport; integral to plasma membrane; synaptic transmission; ion transmembrane transport; postsynaptic membrane; transmembrane transport;
CHRNA3	6	plasma membrane; signal transduction; synaptic transmission; cell junction; dendrite; postsynaptic membrane;
CHRNA4	6	plasma membrane; signal transduction; synaptic transmission; cell junction; dendrite; postsynaptic membrane;
CHRNA5	6	plasma membrane; signal transduction; transport; synaptic transmission; cell junction; postsynaptic membrane;
CHRNB4	6	plasma membrane; signal transduction; integral to plasma membrane; synaptic transmission; cell junction; postsynaptic membrane;
GABBR2	6	plasma membrane; gamma-aminobutyric acid signaling pathway; integral to plasma membrane; synaptic transmission; cell junction; postsynaptic membrane;
GRIA4	6	plasma membrane; transport; synaptic transmission; cell junction; dendrite; postsynaptic membrane;
GRIK4	6	plasma membrane; transport; integral to plasma membrane; synaptic transmission; cell junction; postsynaptic membrane;
GRIN2A	6	plasma membrane; transport; integral to plasma membrane; synaptic transmission; cell junction; postsynaptic membrane;
NLGN1	5	receptor activity; integral to plasma membrane; cell junction; dendrite; postsynaptic membrane;
ABCC1	5	plasma membrane; transporter activity; transport; integral to plasma membrane; transmembrane transport;
ACHE	5	plasma membrane; synaptic transmission; cell junction; dendrite; postsynaptic membrane;
ADCY4	5	plasma membrane; signal transduction; synaptic transmission; dendrite; transmembrane transport;
AQP4	5	plasma membrane; transport; integral to plasma membrane; sensory perception of sound; transmembrane transport;
CHRM1	5	plasma membrane; signal transduction; integral to plasma membrane; cell junction; postsynaptic membrane;
CHRNA7	5	plasma membrane; signal transduction; synaptic transmission; cell junction; postsynaptic membrane;
FXYD2	5	plasma membrane; transporter activity; transport; ion transmembrane transport; transmembrane transport;
GJA1	5	plasma membrane; signal transduction; transport; integral to plasma membrane; ion transmembrane transport;
GRID2	5	plasma membrane; transport; integral to plasma membrane; cell junction; postsynaptic membrane;
HTR6	5	plasma membrane; integral to plasma membrane; synaptic transmission; brain development; dendrite;
SLC6A1	5	plasma membrane; transport; integral to plasma membrane; synaptic transmission; transmembrane transport;
SLC6A2	5	plasma membrane; transport; integral to plasma membrane; synaptic transmission; transmembrane transport;
SLC6A3	5	plasma membrane; transport; integral to plasma membrane; synaptic transmission; transmembrane transport;

Genes shared at least 2 KEGG pathways with GABRA5 (count: 0)

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Region: chr15:27111866..27194357 View in gBrowse