ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GUCY1A2
Previous Symbol	GUC1A2
Symbol Alias	GC-SA2
Approved Name	guanylate cyclase 1, soluble, alpha 2
Location	11q21-q22
Position	chr11:106555148-106889250, -
External Links	HGNC: 4684 Entrez Gene: 2977 Ensembl: ENSG00000152402 UCSC: uc001pjg.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 8)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035556	intracellular signal transduction	Biological Process		44
GO:0005737	cytoplasm	Cellular Component		690
GO:0005525	GTP binding	Molecular Function		53
GO:0004383	guanylate cyclase activity	Molecular Function		1
GO:0030828	positive regulation of cGMP biosynthetic process	Biological Process		3
GO:0020037	heme binding	Molecular Function		23
GO:0007596	blood coagulation	Biological Process		83
GO:0007165	signal transduction	Biological Process	TAS[1683630]	171

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04730	Long-term depression	27	Cerebellar long-term depression (LTD), thought to be a molec...... Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization. More...
hsa00230	Purine metabolism	22
hsa04270	Vascular smooth muscle contraction	33	The vascular smooth muscle cell (VSMC) is a highly specializ...... The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure. More...
hsa04540	Gap junction	27	Gap junctions contain intercellular channels that allow dire...... Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. More...
hsa04970	Salivary secretion	22	Saliva has manifold functions in maintaining the integrity o...... Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP. More...

Genes shared at least 5 GO terms with GUCY1A2 (count: 0)

Genes shared at least 2 KEGG pathways with GUCY1A2 (count: 25)

Gene Symbol	Pathway Count	Pathway List
ITPR1	4	Long-term depression; Vascular smooth muscle contraction; Gap junction; Salivary secretion;
ITPR2	4	Long-term depression; Vascular smooth muscle contraction; Gap junction; Salivary secretion;
PLCB2	4	Long-term depression; Vascular smooth muscle contraction; Gap junction; Salivary secretion;
PLCB3	4	Long-term depression; Vascular smooth muscle contraction; Gap junction; Salivary secretion;
PRKCB	4	Long-term depression; Vascular smooth muscle contraction; Gap junction; Salivary secretion;
PRKG1	4	Long-term depression; Vascular smooth muscle contraction; Gap junction; Salivary secretion;
ADCY4	4	Purine metabolism; Vascular smooth muscle contraction; Gap junction; Salivary secretion;
MAPK1	3	Long-term depression; Vascular smooth muscle contraction; Gap junction;
MAPK3	3	Long-term depression; Vascular smooth muscle contraction; Gap junction;
GRM1	2	Long-term depression; Gap junction;
GRM5	2	Long-term depression; Gap junction;
NOS1	2	Long-term depression; Salivary secretion;
PLA2G10	2	Long-term depression; Vascular smooth muscle contraction;
PLA2G1B	2	Long-term depression; Vascular smooth muscle contraction;
PLA2G2A	2	Long-term depression; Vascular smooth muscle contraction;
PLA2G2D	2	Long-term depression; Vascular smooth muscle contraction;
PLA2G2E	2	Long-term depression; Vascular smooth muscle contraction;
PLA2G3	2	Long-term depression; Vascular smooth muscle contraction;
PLA2G4B	2	Long-term depression; Vascular smooth muscle contraction;
PLA2G5	2	Long-term depression; Vascular smooth muscle contraction;
PLA2G6	2	Long-term depression; Vascular smooth muscle contraction;
ADRA1A	2	Vascular smooth muscle contraction; Salivary secretion;
ADRA1B	2	Vascular smooth muscle contraction; Salivary secretion;
ADRA1D	2	Vascular smooth muscle contraction; Salivary secretion;
ADRB1	2	Gap junction; Salivary secretion;

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Region: chr11:106555148..106889250 View in gBrowse