ADHDgene Database

Gene Report

Basic Info

Approved Symbol	HBS1L
Symbol Alias	ERFS, HBS1, HSPC276, KIAA1038, DKFZp434g247, EF-1a
Approved Name	HBS1-like (S. cerevisiae)
Previous Name	HBS1 (S. cerevisiae)-like
Location	6q23.3
Position	chr6:135281516-135424194, -
External Links	HGNC: 4834 Entrez Gene: 10767 Ensembl: ENSG00000112339 UCSC: uc003qez.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007165	signal transduction	Biological Process	TAS[9872408]	171
GO:0003924	GTPase activity	Molecular Function		41
GO:0003746	translation elongation factor activity	Molecular Function		3
GO:0006412	translation	Biological Process	TAS[9872408]	42
GO:0005525	GTP binding	Molecular Function		53

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03015	mRNA surveillance pathway	17	The mRNA surveillance pathway is a quality control mechanism...... The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins. More...

Genes shared at least 5 GO terms with HBS1L (count: 0)

Genes shared at least 2 KEGG pathways with HBS1L (count: 0)

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Region: chr6:135281516..135424194 View in gBrowse