ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HES1
Previous Symbol	HRY
Symbol Alias	FLJ20408, HES-1, Hes1, bHLHb39
Approved Name	hairy and enhancer of split 1, (Drosophila)
Previous Name	hairy homolog (Drosophila)
Location	3q28-q29
Position	chr3:193853934-193856521, +
External Links	HGNC: 5192 Entrez Gene: 3280 Ensembl: ENSG00000114315 UCSC: uc003ftq.1
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by CNV; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.0163, global P-value=0.081, WHAP TDT P_sum P-value=0.0978; OR=1.23, one or more SNPs with nominal P-value<0.05 located in this gene	Significant

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs4686673	Chr3:193861242(Fwd)	downstream_gene_variant; upstream_gene_variant	1(1/0/0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs2368048	Chr3:193854961(Fwd)	intron_variant; nc_transcript_variant; non_coding_exon_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_50	chr3:194759366-195501036 (NCBI Build 36.1 (hg18))	741671	3q29	Gain

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 77)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 77)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0097150	neuronal stem cell maintenance	Biological Process	IEP[19682396]	2
GO:2000227	negative regulation of pancreatic A cell differentiation	Biological Process		1
GO:2000737	negative regulation of stem cell differentiation	Biological Process	IMP[19682396]	1
GO:2000974	negative regulation of pro-B cell differentiation	Biological Process	IMP[12032823]	1
GO:2000978	negative regulation of forebrain neuron differentiation	Biological Process		1
GO:0071820	N-box binding	Molecular Function		1
GO:0072012	glomerulus vasculature development	Biological Process		1
GO:0072049	comma-shaped body morphogenesis	Biological Process		2
GO:0072050	S-shaped body morphogenesis	Biological Process		2
GO:0072141	renal interstitial cell development	Biological Process		1
GO:0072282	metanephric nephron tubule morphogenesis	Biological Process		2
GO:0090102	cochlea development	Biological Process		5
GO:0097084	vascular smooth muscle cell development	Biological Process		2
GO:0060253	negative regulation of glial cell proliferation	Biological Process		1
GO:0060164	regulation of timing of neuron differentiation	Biological Process		1
GO:0060675	ureteric bud morphogenesis	Biological Process		2
GO:0060412	ventricular septum morphogenesis	Biological Process		5
GO:0061009	common bile duct development	Biological Process		1
GO:0060716	labyrinthine layer blood vessel development	Biological Process		6
GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	Biological Process		1
GO:0061106	negative regulation of stomach neuroendocrine cell differentiation	Biological Process		1
GO:0048469	cell maturation	Biological Process		6
GO:0046427	positive regulation of JAK-STAT cascade	Biological Process		3
GO:0048667	cell morphogenesis involved in neuron differentiation	Biological Process		2
GO:0048538	thymus development	Biological Process		14
GO:0048715	negative regulation of oligodendrocyte differentiation	Biological Process		3
GO:0048711	positive regulation of astrocyte differentiation	Biological Process		4
GO:0060037	pharyngeal system development	Biological Process		5
GO:0048844	artery morphogenesis	Biological Process		9
GO:0016477	cell migration	Biological Process		24
GO:0021537	telencephalon development	Biological Process		4
GO:0021555	midbrain-hindbrain boundary morphogenesis	Biological Process		1
GO:0021557	oculomotor nerve development	Biological Process		1
GO:0007262	STAT protein import into nucleus	Biological Process		1
GO:0007399	nervous system development	Biological Process	TAS[8020957]	54
GO:0008134	transcription factor binding	Molecular Function	NAS[17611704]	38
GO:0008284	positive regulation of cell proliferation	Biological Process		69
GO:0030324	lung development	Biological Process		12
GO:0030513	positive regulation of BMP signaling pathway	Biological Process		5
GO:0030901	midbrain development	Biological Process		5
GO:0031018	endocrine pancreas development	Biological Process		7
GO:0021558	trochlear nerve development	Biological Process		1
GO:0021575	hindbrain morphogenesis	Biological Process		1
GO:0021861	forebrain radial glial cell differentiation	Biological Process		1
GO:0021984	adenohypophysis development	Biological Process		3
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0042668	auditory receptor cell fate determination	Biological Process		1
GO:0043388	positive regulation of DNA binding	Biological Process		3
GO:0042826	histone deacetylase binding	Molecular Function	IPI[12535671]	10
GO:0035910	ascending aorta morphogenesis	Biological Process		2
GO:0035019	somatic stem cell maintenance	Biological Process		7
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	Biological Process		7
GO:0042102	positive regulation of T cell proliferation	Biological Process		11
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[12535671]	64
GO:0046331	lateral inhibition	Biological Process		1
GO:0045977	positive regulation of mitotic cell cycle, embryonic	Biological Process		1
GO:0045598	regulation of fat cell differentiation	Biological Process		2
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0045747	positive regulation of Notch signaling pathway	Biological Process		2
GO:0045608	negative regulation of auditory receptor cell differentiation	Biological Process		1
GO:0003677	DNA binding	Molecular Function	TAS[7906273]	220
GO:0003281	ventricular septum development	Biological Process		5
GO:0003266	regulation of secondary heart field cardioblast proliferation	Biological Process		2
GO:0003151	outflow tract morphogenesis	Biological Process		12
GO:0003143	embryonic heart tube morphogenesis	Biological Process		3
GO:0001889	liver development	Biological Process		14
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	Molecular Function		7
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12535671]	78
GO:0007224	smoothened signaling pathway	Biological Process		10
GO:0007219	Notch signaling pathway	Biological Process	IDA[16160079]; IMP[19682396]	21
GO:0007155	cell adhesion	Biological Process		86
GO:0006461	protein complex assembly	Biological Process		28
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[12535671]	910
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[17681138]	132

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04950	Maturity onset diabetes of the young	3	About 2-5% of type II diabetic patients suffer from a monoge...... About 2-5% of type II diabetic patients suffer from a monogenic disease with autosomal dominant inheritance. This monogenic form of type II diabetes is called maturity onset diabetes of the young (MODY). More...
hsa04330	Notch signaling pathway	8	The Notch signaling pathway is an evolutionarily conserved, ...... The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes. More...

Genes shared at least 5 GO terms with HES1 (count: 102)

Gene Symbol	Pathway Count	Pathway List
HEY2	17	cochlea development; vascular smooth muscle cell development; ventricular septum morphogenesis; labyrinthine layer blood vessel development; transcription factor binding; histone deacetylase binding; ascending aorta morphogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; outflow tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
RBPJ	12	labyrinthine layer blood vessel development; positive regulation of BMP signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; DNA binding; outflow tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
VEGFA	11	cell maturation; artery morphogenesis; nervous system development; positive regulation of cell proliferation; lung development; protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding;
TBX1	11	thymus development; pharyngeal system development; artery morphogenesis; positive regulation of cell proliferation; protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; outflow tract morphogenesis; nucleus; sequence-specific DNA binding transcription factor activity;
ISL1	11	pharyngeal system development; positive regulation of cell proliferation; positive regulation of DNA binding; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of transcription from RNA polymerase II promoter; regulation of secondary heart field cardioblast proliferation; outflow tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
RELA	11	transcription factor binding; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding; liver development; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
FOXE1	10	thymus development; cell migration; transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
TFAP2A	10	protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; outflow tract morphogenesis; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding;
HNF1B	9	endocrine pancreas development; protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
LHX1	8	comma-shaped body morphogenesis; S-shaped body morphogenesis; telencephalon development; nervous system development; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
ID2	8	cell maturation; negative regulation of oligodendrocyte differentiation; positive regulation of astrocyte differentiation; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding;
APC	8	thymus development; cell migration; somatic stem cell maintenance; cell adhesion; protein complex assembly; cytoplasm; nucleus; protein binding;
IKZF1	8	thymus development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
FOXC2	8	artery morphogenesis; transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; nucleus; sequence-specific DNA binding transcription factor activity;
ETS1	8	transcription factor binding; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
FOXF1	8	transcription factor binding; lung development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; smoothened signaling pathway; nucleus;
FOXP1	8	transcription factor binding; lung development; protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; cytoplasm; nucleus;
GATA6	8	transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; liver development; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
SREBF1	8	lung development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
NCOR1	8	histone deacetylase binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
HOXA1	7	cochlea development; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
ZFPM1	7	ventricular septum morphogenesis; transcription factor binding; DNA binding; outflow tract morphogenesis; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; cytoplasm; protein binding;
MAPK1	7	labyrinthine layer blood vessel development; transcription factor binding; positive regulation of cell proliferation; DNA binding; cytoplasm; nucleus; protein binding;
MYB	7	thymus development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; DNA binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; sequence-specific DNA binding transcription factor activity;
HOXA13	7	artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; ventricular septum development; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA5	7	cell migration; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
ZNF423	7	nervous system development; positive regulation of BMP signaling pathway; negative regulation of transcription, DNA-dependent; DNA binding; Notch signaling pathway; nucleus; protein binding;
FOXG1	7	transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding; nucleus; protein binding;
FOXP2	7	transcription factor binding; protein homodimerization activity; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding; cytoplasm; sequence-specific DNA binding transcription factor activity;
HMGA1	7	transcription factor binding; negative regulation of transcription, DNA-dependent; DNA binding; protein complex assembly; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
HOXA7	7	transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
KDM1A	7	transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
MEIS2	7	transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
YAP1	7	positive regulation of cell proliferation; somatic stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; embryonic heart tube morphogenesis; cytoplasm; nucleus; protein binding;
MEN1	7	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding;
STRN3	7	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
WNT11	6	ureteric bud morphogenesis; ventricular septum morphogenesis; artery morphogenesis; negative regulation of transcription, DNA-dependent; outflow tract morphogenesis; cytoplasm;
IL6	6	positive regulation of JAK-STAT cascade; positive regulation of cell proliferation; endocrine pancreas development; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter;
GSK3B	6	cell migration; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cytoplasm; nucleus; protein binding;
IL12B	6	cell migration; protein homodimerization activity; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of T cell proliferation; cytoplasm; protein binding;
NCK1	6	cell migration; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding;
ARRB1	6	transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; cytoplasm; nucleus; protein binding;
DAXX	6	transcription factor binding; protein homodimerization activity; negative regulation of transcription, DNA-dependent; cytoplasm; nucleus; protein binding;
DRAP1	6	transcription factor binding; sequence-specific DNA binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
E2F5	6	transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; DNA binding; cytoplasm; protein binding; sequence-specific DNA binding transcription factor activity;
FOXD4	6	transcription factor binding; positive regulation of BMP signaling pathway; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
MED1	6	transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; liver development; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
ONECUT2	6	endocrine pancreas development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; liver development; nucleus; sequence-specific DNA binding transcription factor activity;
MLL	6	protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; protein complex assembly; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
LPIN1	6	histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; regulation of fat cell differentiation; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus;
NCOR2	6	histone deacetylase binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; nucleus; protein binding;
NIPBL	6	histone deacetylase binding; negative regulation of transcription, DNA-dependent; outflow tract morphogenesis; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
PRDM1	6	histone deacetylase binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
SPI1	6	somatic stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; sequence-specific DNA binding transcription factor activity;
AATF	6	positive regulation of transcription from RNA polymerase II promoter; cell adhesion; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
ATXN1	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; DNA binding; cytoplasm; nucleus; protein binding;
HOXB1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
IRF7	6	positive regulation of transcription from RNA polymerase II promoter; DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding;
MAF	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
MTA2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
POU2F3	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
SNW1	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; nucleus; protein binding;
CREBZF	6	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
ZNF24	6	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding; DNA binding; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
TCF25	6	DNA binding; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
FGF10	5	thymus development; somatic stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Notch signaling pathway; nucleus;
HOXA3	5	thymus development; positive regulation of cell proliferation; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
LMO4	5	thymus development; transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; ventricular septum development; sequence-specific DNA binding transcription factor activity;
TGFBR1	5	thymus development; pharyngeal system development; artery morphogenesis; positive regulation of cell proliferation; protein binding;
DRD3	5	negative regulation of oligodendrocyte differentiation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; protein binding;
PRPF19	5	positive regulation of astrocyte differentiation; DNA binding; cytoplasm; nucleus; protein binding;
NCK2	5	cell migration; positive regulation of T cell proliferation; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding;
ACHE	5	nervous system development; protein homodimerization activity; cell adhesion; nucleus; protein binding;
FOXL1	5	transcription factor binding; sequence-specific DNA binding; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
IGHMBP2	5	transcription factor binding; DNA binding; cytoplasm; nucleus; protein binding;
SORBS3	5	transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; cell adhesion; nucleus; protein binding;
ADAM17	5	positive regulation of cell proliferation; Notch signaling pathway; cell adhesion; cytoplasm; protein binding;
MTA3	5	positive regulation of cell proliferation; sequence-specific DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
CORO1A	5	protein homodimerization activity; positive regulation of T cell proliferation; cytoplasm; nucleus; protein binding;
HSF2	5	protein homodimerization activity; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
PDE2A	5	protein homodimerization activity; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding;
ZBTB16	5	protein homodimerization activity; negative regulation of transcription, DNA-dependent; DNA binding; nucleus; protein binding;
NRIP1	5	histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
TCF21	5	histone deacetylase binding; positive regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; negative regulation of transcription from RNA polymerase II promoter; nucleus;
BCL9	5	somatic stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
ESRRA	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; nucleus; protein binding;
FLCN	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding;
HOXA2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
KAT5	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
NR4A2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; cytoplasm; nucleus; protein binding;
NR5A1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; nucleus; protein binding;
BCLAF1	5	negative regulation of transcription, DNA-dependent; DNA binding; cytoplasm; nucleus; protein binding;
HINFP	5	negative regulation of transcription, DNA-dependent; DNA binding; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
RREB1	5	negative regulation of transcription, DNA-dependent; DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
XRCC5	5	negative regulation of transcription, DNA-dependent; DNA binding; cytoplasm; nucleus; protein binding;
ZNF263	5	negative regulation of transcription, DNA-dependent; DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA9	5	sequence-specific DNA binding; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
PGR	5	sequence-specific DNA binding; DNA binding; cytoplasm; nucleus; protein binding;
PKNOX2	5	sequence-specific DNA binding; DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
NFIL3	5	DNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
LPXN	5	cell adhesion; protein complex assembly; cytoplasm; nucleus; protein binding;

Genes shared at least 2 KEGG pathways with HES1 (count: 0)

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Region: chr3:193853934..193856521 View in gBrowse