ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HEY2
Symbol Alias	bHLHb32, HERP1
Approved Name	hairy/enhancer-of-split related with YRPW motif 2
Location	6q
Position	chr6:126068810-126082415, +
External Links	HGNC: 4881 Entrez Gene: 23493 Ensembl: ENSG00000135547 UCSC: uc003qad.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 65)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 65)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[15485867]	132
GO:0005515	protein binding	Molecular Function	IPI[11486045]	910
GO:0009948	anterior/posterior axis specification	Biological Process		3
GO:0010460	positive regulation of heart rate	Biological Process		4
GO:0007219	Notch signaling pathway	Biological Process		21
GO:0008134	transcription factor binding	Molecular Function	NAS[17611704]	38
GO:0003195	tricuspid valve formation	Biological Process		2
GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation	Biological Process		1
GO:0003184	pulmonary valve morphogenesis	Biological Process		1
GO:0003186	tricuspid valve morphogenesis	Biological Process		1
GO:0003215	cardiac right ventricle morphogenesis	Biological Process		2
GO:0003222	ventricular trabecula myocardium morphogenesis	Biological Process		3
GO:0003208	cardiac ventricle morphogenesis	Biological Process		1
GO:0003214	cardiac left ventricle morphogenesis	Biological Process		3
GO:0001102	RNA polymerase II activating transcription factor binding	Molecular Function	IPI[16293227]	6
GO:0000988	protein binding transcription factor activity	Molecular Function		4
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity	Molecular Function		1
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[16293227]; IMP[11486045]	78
GO:0003171	atrioventricular valve development	Biological Process		1
GO:0003151	outflow tract morphogenesis	Biological Process		12
GO:0003150	muscular septum morphogenesis	Biological Process		1
GO:0001570	vasculogenesis	Biological Process		10
GO:2001212	regulation of vasculogenesis	Biological Process		1
GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	Biological Process		1
GO:2000723	negative regulation of cardiac vascular smooth muscle cell differentiation	Biological Process		1
GO:2000678	negative regulation of transcription regulatory region DNA binding	Biological Process	IDA[10692439]	2
GO:0097084	vascular smooth muscle cell development	Biological Process	IEP[15821257]	2
GO:0090102	cochlea development	Biological Process		5
GO:0065004	protein-DNA complex assembly	Biological Process		1
GO:0061314	Notch signaling involved in heart development	Biological Process	IC[12372254]	2
GO:0061156	pulmonary artery morphogenesis	Biological Process		1
GO:0060716	labyrinthine layer blood vessel development	Biological Process		6
GO:0060842	arterial endothelial cell differentiation	Biological Process		1
GO:0060948	cardiac vascular smooth muscle cell development	Biological Process		2
GO:0060977	coronary vasculature morphogenesis	Biological Process		1
GO:0060411	cardiac septum morphogenesis	Biological Process		2
GO:0060412	ventricular septum morphogenesis	Biological Process		5
GO:0060413	atrial septum morphogenesis	Biological Process		4
GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter	Biological Process	IDA[10692439]	1
GO:0055015	ventricular cardiac muscle cell development	Biological Process		2
GO:0060045	positive regulation of cardiac muscle cell proliferation	Biological Process		4
GO:0060317	cardiac epithelial to mesenchymal transition	Biological Process		2
GO:0060347	heart trabecula formation	Biological Process		2
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[12535671]	64
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0046983	protein dimerization activity	Molecular Function		26
GO:0051145	smooth muscle cell differentiation	Biological Process	NAS[10692439]	6
GO:0045165	cell fate commitment	Biological Process		4
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA[11486045]	72
GO:0045746	negative regulation of Notch signaling pathway	Biological Process		2
GO:0045607	regulation of auditory receptor cell differentiation	Biological Process		1
GO:0035939	microsatellite binding	Molecular Function		1
GO:0035912	dorsal aorta morphogenesis	Biological Process		2
GO:0042826	histone deacetylase binding	Molecular Function	IPI[12535671]	10
GO:0036304	umbilical cord morphogenesis	Biological Process		1
GO:0016580	Sin3 complex	Cellular Component	IDA[11486045]	2
GO:0014898	cardiac muscle hypertrophy in response to stress	Biological Process		2
GO:0035910	ascending aorta morphogenesis	Biological Process		2
GO:0017053	transcriptional repressor complex	Cellular Component	IDA[11486045]	8
GO:0010629	negative regulation of gene expression	Biological Process		13
GO:0010621	negative regulation of transcription by transcription factor localization	Biological Process		1
GO:0014031	mesenchymal cell development	Biological Process		1
GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Biological Process		2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HEY2 (count: 72)

Gene Symbol	Pathway Count	Pathway List
HES1	17	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; Notch signaling pathway; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; vascular smooth muscle cell development; cochlea development; labyrinthine layer blood vessel development; ventricular septum morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; histone deacetylase binding; ascending aorta morphogenesis;
RBPJ	15	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; Notch signaling pathway; ventricular trabecula myocardium morphogenesis; cardiac left ventricle morphogenesis; negative regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; Notch signaling involved in heart development; labyrinthine layer blood vessel development; positive regulation of cardiac muscle cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; dorsal aorta morphogenesis;
NCOR1	11	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; Notch signaling pathway; RNA polymerase II activating transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; histone deacetylase binding; Sin3 complex; transcriptional repressor complex;
GATA6	9	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cardiac muscle cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation;
ISL1	9	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; cardiac right ventricle morphogenesis; RNA polymerase II activating transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; atrial septum morphogenesis; positive regulation of transcription from RNA polymerase II promoter;
TFAP2A	9	nucleus; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; sequence-specific DNA binding;
ZFPM1	9	cytoplasm; protein binding; transcription factor binding; tricuspid valve formation; RNA polymerase II activating transcription factor binding; outflow tract morphogenesis; ventricular septum morphogenesis; atrial septum morphogenesis; transcriptional repressor complex;
FOXC2	8	nucleus; sequence-specific DNA binding transcription factor activity; Notch signaling pathway; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; vasculogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
FOXF1	8	nucleus; transcription factor binding; cardiac left ventricle morphogenesis; negative regulation of transcription from RNA polymerase II promoter; vasculogenesis; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; sequence-specific DNA binding;
RELA	8	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
FOXE1	7	nucleus; sequence-specific DNA binding transcription factor activity; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA7	7	nucleus; sequence-specific DNA binding transcription factor activity; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
ID2	7	nucleus; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein dimerization activity; negative regulation of gene expression;
KDM1A	7	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
MEIS2	7	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
MEN1	7	nucleus; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
POU2F3	7	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; sequence-specific DNA binding;
PRDM1	7	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; cell fate commitment; sequence-specific DNA binding; histone deacetylase binding;
SREBF1	7	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; sequence-specific DNA binding;
STRN3	7	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
VEGFA	7	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; vasculogenesis; cardiac vascular smooth muscle cell development; positive regulation of transcription from RNA polymerase II promoter;
ARRB1	6	nucleus; cytoplasm; protein binding; Notch signaling pathway; transcription factor binding; positive regulation of transcription from RNA polymerase II promoter;
ETS1	6	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
FLCN	6	nucleus; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; negative regulation of gene expression;
FOXG1	6	nucleus; protein binding; transcription factor binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
FOXP1	6	nucleus; cytoplasm; transcription factor binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HNF1B	6	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA1	6	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; cochlea development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
IKZF1	6	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
LHX2	6	nucleus; sequence-specific DNA binding transcription factor activity; protein binding transcription factor activity; negative regulation of transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
MAF	6	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
MED1	6	nucleus; protein binding; transcription factor binding; ventricular trabecula myocardium morphogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MTA2	6	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
NCOR2	6	nucleus; protein binding; Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; histone deacetylase binding; transcriptional repressor complex;
NIPBL	6	nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; outflow tract morphogenesis; negative regulation of transcription, DNA-dependent; histone deacetylase binding;
SNW1	6	nucleus; protein binding; Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
TBX1	6	nucleus; sequence-specific DNA binding transcription factor activity; outflow tract morphogenesis; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; sequence-specific DNA binding;
AATF	5	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; positive regulation of transcription from RNA polymerase II promoter;
ATXN1	5	nucleus; cytoplasm; protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
BSX	5	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
CREBZF	5	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding;
DAXX	5	nucleus; cytoplasm; protein binding; transcription factor binding; negative regulation of transcription, DNA-dependent;
DRAP1	5	nucleus; sequence-specific DNA binding transcription factor activity; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
FOXD4	5	nucleus; sequence-specific DNA binding transcription factor activity; transcription factor binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
GSK3B	5	nucleus; cytoplasm; protein binding; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
HINFP	5	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription, DNA-dependent; negative regulation of gene expression;
HMGA1	5	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor binding; negative regulation of transcription, DNA-dependent;
HOXA13	5	nucleus; sequence-specific DNA binding transcription factor activity; vasculogenesis; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA2	5	nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA5	5	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA9	5	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; sequence-specific DNA binding;
HOXB1	5	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
IRF7	5	nucleus; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
KAT5	5	nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
LHX1	5	nucleus; sequence-specific DNA binding transcription factor activity; anterior/posterior axis specification; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding;
LPIN1	5	nucleus; cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; histone deacetylase binding;
MAPK1	5	nucleus; cytoplasm; protein binding; transcription factor binding; labyrinthine layer blood vessel development;
NR4A2	5	nucleus; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
NRIP1	5	nucleus; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; histone deacetylase binding;
ONECUT2	5	nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; cell fate commitment; sequence-specific DNA binding;
PER1	5	nucleus; cytoplasm; protein binding transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent;
PGR	5	nucleus; cytoplasm; protein binding; sequence-specific DNA binding; negative regulation of gene expression;
TCF21	5	nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity; histone deacetylase binding;
TCF25	5	nucleus; cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter;
TP53BP1	5	nucleus; cytoplasm; protein binding; RNA polymerase II activating transcription factor binding; positive regulation of transcription from RNA polymerase II promoter;
WWOX	5	nucleus; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; protein dimerization activity;
YAP1	5	nucleus; cytoplasm; protein binding; vasculogenesis; positive regulation of transcription from RNA polymerase II promoter;
ZNF24	5	nucleus; sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding;
E2F5	5	cytoplasm; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor binding; positive regulation of transcription from RNA polymerase II promoter;
FOXP2	5	cytoplasm; sequence-specific DNA binding transcription factor activity; transcription factor binding; negative regulation of transcription, DNA-dependent; sequence-specific DNA binding;
MYB	5	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
SPI1	5	sequence-specific DNA binding transcription factor activity; protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with HEY2 (count: 0)

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Region: chr6:126068810..126082415 View in gBrowse