ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HOXA7
Previous Symbol	HOX1A, HOX1
Approved Name	homeobox A7
Previous Name	homeo box A7
Location	7p15.2
Position	chr7:27193335-27197555, -
External Links	HGNC: 5108 Entrez Gene: 3204 Ensembl: ENSG00000122592 UCSC: uc003sys.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
7p15	chr7:20900000-28800000	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[11435435]	64
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0048704	embryonic skeletal system morphogenesis	Biological Process		9
GO:0048863	stem cell differentiation	Biological Process		1
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0005634	nucleus	Cellular Component	IC[11435435]	770
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0008134	transcription factor binding	Molecular Function	IPI[18973687]	38
GO:0009952	anterior/posterior pattern specification	Biological Process		26
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA[11435435]	72
GO:0045617	negative regulation of keratinocyte differentiation	Biological Process	IDA[11435435]	1
GO:0045656	negative regulation of monocyte differentiation	Biological Process	IDA[14704364]	1
GO:0001525	angiogenesis	Biological Process	IEP[17972163]	35
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[11435435]	78
GO:0002686	negative regulation of leukocyte migration	Biological Process	IDA[14704364]	1
GO:0001953	negative regulation of cell-matrix adhesion	Biological Process	IDA[14704364]	5

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HOXA7 (count: 48)

Gene Symbol	Pathway Count	Pathway List
FOXE1	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HES1	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HEY2	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
KDM1A	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter;
MEN1	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; embryonic skeletal system morphogenesis; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HOXA2	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HOXA5	7	positive regulation of transcription from RNA polymerase II promoter; embryonic skeletal system morphogenesis; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding;
HOXB1	7	positive regulation of transcription from RNA polymerase II promoter; embryonic skeletal system morphogenesis; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding;
TBX1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding; angiogenesis;
HOXA3	7	embryonic skeletal system morphogenesis; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding; angiogenesis;
HOXB3	7	embryonic skeletal system morphogenesis; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; angiogenesis; negative regulation of transcription from RNA polymerase II promoter;
GATA6	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding; negative regulation of transcription from RNA polymerase II promoter;
RBPJ	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; angiogenesis; negative regulation of transcription from RNA polymerase II promoter;
RELA	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding; sequence-specific DNA binding;
ETS1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; transcription factor binding; sequence-specific DNA binding;
FOXC2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HNF1B	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; anterior/posterior pattern specification; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HOXA1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding;
IKZF1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
MEIS2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
SREBF1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HOXA4	6	embryonic skeletal system morphogenesis; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding;
HOXA6	6	embryonic skeletal system morphogenesis; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding;
DRAP1	6	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; transcription factor binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
CREBZF	5	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
ELK3	5	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; angiogenesis;
FOXG1	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor binding; sequence-specific DNA binding;
FOXP1	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor binding; sequence-specific DNA binding;
HMGA1	5	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; transcription factor binding;
KAT5	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
LHX1	5	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus; anterior/posterior pattern specification; sequence-specific DNA binding;
MYB	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
STRN3	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter;
TFAP2A	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
ZNF24	5	negative regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
FOXD4	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription factor binding; sequence-specific DNA binding;
FOXF1	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor binding; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
HOXA13	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
LHX2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
MAF	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
MED1	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; transcription factor binding; angiogenesis; negative regulation of transcription from RNA polymerase II promoter;
MTA2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
ONECUT2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
POU2F3	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding;
HOXA9	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; anterior/posterior pattern specification; sequence-specific DNA binding;
NCOR1	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;
PRDM1	5	sequence-specific DNA binding transcription factor activity; nucleus; transcription, DNA-dependent; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with HOXA7 (count: 0)

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Region: chr7:27193335..27197555 View in gBrowse