ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HTR3A
Previous Symbol	HTR3
Symbol Alias	5-HT3R, 5-HT3A
Approved Name	5-hydroxytryptamine (serotonin) receptor 3A
Location	11q23.1-q23.2
Position	chr11:113845603-113861035, +
External Links	HGNC: 5297 Entrez Gene: 3359 Ensembl: ENSG00000166736 UCSC: uc010rxa.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)	little evidence of association with ADHD was found.	Non-significant

Gene related SNPs (count: 13)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1150222	Chr11:113846872(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant	1(1/0/0)
rs1176717	Chr11:113855342(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(1/0/0)

LD-proxies (count: 11)

rs_ID	Location	Functional Annotation
rs1062613	Chr11:113846006(Fwd)	5_prime_UTR_variant; upstream_gene_variant
rs2276302	Chr11:113850140(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs10891611	Chr11:113851413(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs948983	Chr11:113855977(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs11214796	Chr11:113854679(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs1182457	Chr11:113861749(Fwd)	downstream_gene_variant
rs1176713	Chr11:113860425(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; synonymous_variant
rs7115470	Chr11:113863131(Fwd)	downstream_gene_variant
rs1176720	Chr11:113849753(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs1176722	Chr11:113848474(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs11214800	Chr11:113862930(Fwd)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0034220	ion transmembrane transport	Biological Process		11
GO:0030054	cell junction	Cellular Component		77
GO:0051378	serotonin binding	Molecular Function	IDA[7565620]	7
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0055085	transmembrane transport	Biological Process		82
GO:0005886	plasma membrane	Cellular Component		772
GO:0005232	serotonin-activated cation-selective channel activity	Molecular Function	TAS[7565620]	2
GO:0006810	transport	Biological Process		62
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7565620]	220
GO:0007268	synaptic transmission	Biological Process	TAS[7565620]	96
GO:0007210	serotonin receptor signaling pathway	Biological Process	IDA[7565620]	9
GO:0016021	integral to membrane	Cellular Component		845
GO:0007586	digestion	Biological Process	TAS[7565620]	13
GO:0004872	receptor activity	Molecular Function	TAS[9950429]	36
GO:0004993	serotonin receptor activity	Molecular Function	IDA[7565620]	13
GO:0005230	extracellular ligand-gated ion channel activity	Molecular Function		7

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HTR3A (count: 32)

Gene Symbol	Pathway Count	Pathway List
GABRA5	10	ion transmembrane transport; cell junction; postsynaptic membrane; transmembrane transport; plasma membrane; transport; integral to plasma membrane; synaptic transmission; receptor activity; extracellular ligand-gated ion channel activity;
GABRB3	9	ion transmembrane transport; cell junction; postsynaptic membrane; transmembrane transport; plasma membrane; transport; integral to plasma membrane; synaptic transmission; extracellular ligand-gated ion channel activity;
HTR3B	9	ion transmembrane transport; postsynaptic membrane; transmembrane transport; plasma membrane; serotonin-activated cation-selective channel activity; transport; integral to plasma membrane; synaptic transmission; serotonin receptor activity;
GABRG3	8	ion transmembrane transport; cell junction; postsynaptic membrane; transmembrane transport; plasma membrane; synaptic transmission; integral to membrane; extracellular ligand-gated ion channel activity;
CHRM3	6	cell junction; postsynaptic membrane; plasma membrane; integral to plasma membrane; digestion; receptor activity;
CHRNB4	6	cell junction; postsynaptic membrane; plasma membrane; integral to plasma membrane; synaptic transmission; integral to membrane;
GRIK1	6	cell junction; postsynaptic membrane; plasma membrane; transport; integral to plasma membrane; synaptic transmission;
GRIK4	6	cell junction; postsynaptic membrane; plasma membrane; transport; integral to plasma membrane; synaptic transmission;
GRIN2A	6	cell junction; postsynaptic membrane; plasma membrane; transport; integral to plasma membrane; synaptic transmission;
GRIN2B	6	cell junction; postsynaptic membrane; plasma membrane; transport; integral to plasma membrane; synaptic transmission;
HTR1E	6	serotonin binding; plasma membrane; integral to plasma membrane; synaptic transmission; serotonin receptor signaling pathway; serotonin receptor activity;
HTR1F	6	serotonin binding; plasma membrane; integral to plasma membrane; synaptic transmission; serotonin receptor signaling pathway; serotonin receptor activity;
HTR2A	6	serotonin binding; plasma membrane; integral to plasma membrane; synaptic transmission; serotonin receptor signaling pathway; serotonin receptor activity;
HTR2C	6	serotonin binding; plasma membrane; synaptic transmission; serotonin receptor signaling pathway; integral to membrane; serotonin receptor activity;
SLC6A1	6	transmembrane transport; plasma membrane; transport; integral to plasma membrane; synaptic transmission; integral to membrane;
SLC6A3	6	transmembrane transport; plasma membrane; transport; integral to plasma membrane; synaptic transmission; integral to membrane;
ATP2B3	5	ion transmembrane transport; transmembrane transport; plasma membrane; transport; integral to membrane;
CHRNA3	5	cell junction; postsynaptic membrane; plasma membrane; synaptic transmission; integral to membrane;
CHRNA4	5	cell junction; postsynaptic membrane; plasma membrane; synaptic transmission; integral to membrane;
CHRNA5	5	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission;
CHRNA7	5	cell junction; postsynaptic membrane; plasma membrane; synaptic transmission; integral to membrane;
GABBR2	5	cell junction; postsynaptic membrane; plasma membrane; integral to plasma membrane; synaptic transmission;
GABRG1	5	cell junction; postsynaptic membrane; plasma membrane; synaptic transmission; extracellular ligand-gated ion channel activity;
GRIA4	5	cell junction; postsynaptic membrane; plasma membrane; transport; synaptic transmission;
GRID2	5	cell junction; postsynaptic membrane; plasma membrane; transport; integral to plasma membrane;
NRXN1	5	cell junction; plasma membrane; integral to plasma membrane; integral to membrane; receptor activity;
TRPV1	5	cell junction; postsynaptic membrane; transport; integral to plasma membrane; integral to membrane;
HTR1B	5	serotonin binding; plasma membrane; integral to plasma membrane; synaptic transmission; serotonin receptor activity;
HTR1D	5	serotonin binding; plasma membrane; integral to plasma membrane; synaptic transmission; serotonin receptor activity;
GRM7	5	postsynaptic membrane; plasma membrane; integral to plasma membrane; synaptic transmission; integral to membrane;
SLC6A2	5	transmembrane transport; plasma membrane; transport; integral to plasma membrane; synaptic transmission;
HTR7	5	plasma membrane; integral to plasma membrane; synaptic transmission; serotonin receptor signaling pathway; serotonin receptor activity;

Genes shared at least 2 KEGG pathways with HTR3A (count: 0)

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Region: chr11:113845603..113861035 View in gBrowse