ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HTR4
Symbol Alias	5-HT4
Approved Name	5-hydroxytryptamine (serotonin) receptor 4
Location	5q31-q33
Position	chr5:147830595-148056798, -
External Links	HGNC: 5299 Entrez Gene: 3360 Ensembl: ENSG00000164270 UCSC: uc003lpm.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Li J, 2006(b)	haplotype C/G from variants 83097 C>T/83198 A>G TDT P-value=0.003, X²=8.783; haplotype C/G/C from 83097 C> T/83198 A>G/-36 C>T TDT P-value=0.016, X²=5.762; HTR4 gene may play a role in the genetic predisposition to ADHD	Significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 3)

Variant Name	Variant Type	No. of Studies (significant/non-significant/trend)
HTR4_-36C>T	point mutation	1 (0/1/0)
HTR4_83198A>G	point mutation	1 (0/1/0)
HTR4_83097C>T	point mutation	1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007210	serotonin receptor signaling pathway	Biological Process	IDA[16102731]; TAS[9603189]	9
GO:0008284	positive regulation of cell proliferation	Biological Process	IMP[15925089]	69
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[9351641]	72
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process	TAS[9603189]	18
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9276448]	220
GO:0005737	cytoplasm	Cellular Component	IDA[15925089]	690
GO:0005768	endosome	Cellular Component		27
GO:0004993	serotonin receptor activity	Molecular Function	IDA[16102731]	13
GO:0016020	membrane	Cellular Component	IDA[16102731]	139

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with HTR4 (count: 12)

Gene Symbol	Pathway Count	Pathway List
HTR1A	6	serotonin receptor signaling pathway; positive regulation of cell proliferation; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; serotonin receptor activity;
HTR1E	6	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; plasma membrane; integral to plasma membrane; serotonin receptor activity;
HTR5A	6	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; plasma membrane; integral to plasma membrane; serotonin receptor activity;
HTR1B	6	G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; plasma membrane; integral to plasma membrane; cytoplasm; serotonin receptor activity;
HTR1F	5	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; plasma membrane; integral to plasma membrane; serotonin receptor activity;
HTR2A	5	serotonin receptor signaling pathway; positive regulation of cell proliferation; plasma membrane; integral to plasma membrane; serotonin receptor activity;
HTR7	5	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; plasma membrane; integral to plasma membrane; serotonin receptor activity;
ADRA2A	5	positive regulation of cell proliferation; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; cytoplasm;
CHRM1	5	positive regulation of cell proliferation; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; membrane;
EDNRA	5	positive regulation of cell proliferation; G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; membrane;
ADRA2C	5	G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; cytoplasm; endosome;
CCR5	5	G-protein coupled receptor signaling pathway; plasma membrane; integral to plasma membrane; cytoplasm; endosome;

Genes shared at least 2 KEGG pathways with HTR4 (count: 30)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr5:147830595..148056798 View in gBrowse