ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HTR5A
Symbol Alias	5-HT5A
Approved Name	5-hydroxytryptamine (serotonin) receptor 5A
Location	7q36.1
Position	chr7:154862034-154877459, +
External Links	HGNC: 5300 Entrez Gene: 3361 Ensembl: ENSG00000157219 UCSC: uc003wlu.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Li J, 2006(e)	biased transmission of either alleles or specific haplotypes was not observed to probands	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
HTR5A_-19G>C	point mutation		1 (0/1/0)
HTR5A_12A>T	point mutation		1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043204	perikaryon	Cellular Component		12
GO:0032355	response to estradiol stimulus	Biological Process		18
GO:0030425	dendrite	Cellular Component		46
GO:0021766	hippocampus development	Biological Process		7
GO:0019933	cAMP-mediated signaling	Biological Process		3
GO:0007210	serotonin receptor signaling pathway	Biological Process	IDA[7988681]	9
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process		18
GO:0007186	G-protein coupled receptor signaling pathway	Biological Process	TAS[7988681]	72
GO:0005887	integral to plasma membrane	Cellular Component	TAS[7988681]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005791	rough endoplasmic reticulum	Cellular Component		7
GO:0004993	serotonin receptor activity	Molecular Function	IDA[7988681]	13

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with HTR5A (count: 8)

Gene Symbol	Pathway Count	Pathway List
HTR6	6	response to estradiol stimulus; dendrite; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; plasma membrane; serotonin receptor activity;
EPHA5	6	dendrite; hippocampus development; cAMP-mediated signaling; integral to plasma membrane; plasma membrane; rough endoplasmic reticulum;
HTR1E	6	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; serotonin receptor activity;
HTR4	6	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; serotonin receptor activity;
HTR1A	5	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; serotonin receptor activity;
HTR1F	5	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; plasma membrane; serotonin receptor activity;
HTR7	5	serotonin receptor signaling pathway; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; integral to plasma membrane; plasma membrane; serotonin receptor activity;
HTR1B	5	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G-protein coupled receptor signaling pathway; integral to plasma membrane; plasma membrane; serotonin receptor activity;

Genes shared at least 2 KEGG pathways with HTR5A (count: 30)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr7:154862034..154877459 View in gBrowse