ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HTR6
Symbol Alias	5-HT6, 5-HT6R
Approved Name	5-hydroxytryptamine (serotonin) receptor 6
Location	1p36-p35
Position	chr1:19991780-20006055, +
External Links	HGNC: 5301 Entrez Gene: 3362 Ensembl: ENSG00000158748 UCSC: uc001bcl.2
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Li J, 2006(e)	no biased transmission of any alleles of 267C>T was observed	Non-significant
Ribases M, 2009(b)	little evidence of association with ADHD was found.	Non-significant

Gene related SNPs (count: 6)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs9659997	Chr1:20002518(Fwd)	intron_variant	1(1/0/0)

LD-proxies (count: 5)

rs_ID	Location	Functional Annotation
rs10917509	Chr1:19992066(Fwd)	5_prime_UTR_variant
rs6693503	Chr1:19987294(Fwd)	downstream_gene_variant; upstream_gene_variant
rs10917513	Chr1:20006887(Fwd)	downstream_gene_variant
rs4912141	Chr1:20001896(Fwd)	intron_variant
rs1883565	Chr1:20008507(Fwd)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
HTR6_267C>T	point mutation		1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004993	serotonin receptor activity	Molecular Function		13
GO:0004969	histamine receptor activity	Molecular Function	TAS[8522988]	2
GO:0032355	response to estradiol stimulus	Biological Process		18
GO:0033603	positive regulation of dopamine secretion	Biological Process		2
GO:0042493	response to drug	Biological Process		68
GO:0060291	long-term synaptic potentiation	Biological Process		5
GO:0014053	negative regulation of gamma-aminobutyric acid secretion	Biological Process		1
GO:0014054	positive regulation of gamma-aminobutyric acid secretion	Biological Process		3
GO:0014058	negative regulation of acetylcholine secretion	Biological Process		1
GO:0030425	dendrite	Cellular Component		46
GO:0007268	synaptic transmission	Biological Process	TAS[8522988]	96
GO:0007420	brain development	Biological Process		33
GO:0007612	learning	Biological Process		13
GO:0014050	negative regulation of glutamate secretion	Biological Process		3
GO:0005515	protein binding	Molecular Function	IPI[17189269]	910
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component	TAS[8522988]	220
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Biological Process		18

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with HTR6 (count: 18)

Gene Symbol	Pathway Count	Pathway List
HTR1B	6	serotonin receptor activity; response to drug; synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
HTR5A	6	serotonin receptor activity; response to estradiol stimulus; dendrite; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
SLC6A1	6	response to estradiol stimulus; positive regulation of gamma-aminobutyric acid secretion; synaptic transmission; learning; plasma membrane; integral to plasma membrane;
DRD1	6	response to drug; long-term synaptic potentiation; protein binding; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
HTR1D	5	serotonin receptor activity; synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
HTR1E	5	serotonin receptor activity; synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
HTR1F	5	serotonin receptor activity; synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
HTR2A	5	serotonin receptor activity; response to drug; synaptic transmission; plasma membrane; integral to plasma membrane;
HTR7	5	serotonin receptor activity; synaptic transmission; plasma membrane; integral to plasma membrane; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;
SLC6A4	5	response to estradiol stimulus; response to drug; protein binding; plasma membrane; integral to plasma membrane;
DRD2	5	response to drug; dendrite; protein binding; plasma membrane; integral to plasma membrane;
DRD3	5	response to drug; learning; protein binding; plasma membrane; integral to plasma membrane;
GRIN2A	5	response to drug; synaptic transmission; protein binding; plasma membrane; integral to plasma membrane;
SLC6A3	5	response to drug; synaptic transmission; protein binding; plasma membrane; integral to plasma membrane;
GRIK1	5	positive regulation of gamma-aminobutyric acid secretion; dendrite; synaptic transmission; plasma membrane; integral to plasma membrane;
GABRA5	5	dendrite; synaptic transmission; brain development; plasma membrane; integral to plasma membrane;
GRM7	5	dendrite; synaptic transmission; negative regulation of glutamate secretion; plasma membrane; integral to plasma membrane;
GRIN2B	5	synaptic transmission; learning; protein binding; plasma membrane; integral to plasma membrane;

Genes shared at least 2 KEGG pathways with HTR6 (count: 30)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr1:19991780..20006055 View in gBrowse