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Gene Report
Basic Info
| Approved Symbol | IRF9 |
|---|---|
| Previous Symbol | ISGF3G |
| Approved Name | interferon regulatory factor 9 |
| Previous Name | interferon-stimulated transcription factor 3, gamma (48kD), "interferon-stimulated transcription factor 3, gamma 48kDa" |
| Location | 14q11.2 |
| Position | chr14:24630262-24635774, + |
| External Links |
HGNC: 6131 Entrez Gene: 10379 Ensembl: ENSG00000213928 UCSC: uc001wmq.2 |
| No. of Studies | 0 (significant: 0; non-significant: 0; trend: 0) |
| Source | Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
| Region Name | Position | No. of Studies (significant/non-significant/trend)  |
|---|---|---|
| 14q12 | chr14:24600000-33300000 | 1 (1/0/0) |
Gene related GO terms (count: 14)
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 14)
| ID | Name | Type | Evidence[PMID] | No. of Genes in ADHDgene |
|---|---|---|---|---|
| GO:0005634 | nucleus | Cellular Component | TAS[1630447] | 770 |
| GO:0005515 | protein binding | Molecular Function | 910 | |
| GO:0003700 | sequence-specific DNA binding transcription factor activity | Molecular Function | 132 | |
| GO:0000975 | regulatory region DNA binding | Molecular Function | 2 | |
| GO:0060333 | interferon-gamma-mediated signaling pathway | Biological Process | 8 | |
| GO:0060337 | type I interferon-mediated signaling pathway | Biological Process | 5 | |
| GO:0005829 | cytosol | Cellular Component | 447 | |
| GO:0006366 | transcription from RNA polymerase II promoter | Biological Process | TAS[1630447] | 62 |
| GO:0005654 | nucleoplasm | Cellular Component | 183 | |
| GO:0005737 | cytoplasm | Cellular Component | 690 | |
| GO:0045351 | type I interferon biosynthetic process | Biological Process | 2 | |
| GO:0051607 | defense response to virus | Biological Process | 15 | |
| GO:0007166 | cell surface receptor signaling pathway | Biological Process | TAS[1630447] | 35 |
| GO:0019221 | cytokine-mediated signaling pathway | Biological Process | 28 |
Gene related KEGG pathways (count: 4)
| ID | Name | No. of Genes in ADHDgene | Brief Description |
|---|---|---|---|
| hsa04380 | Osteoclast differentiation | 25 | The osteoclasts, multinucleared cells originating from the h...... The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast. More... |
| hsa05160 | Hepatitis C | 17 | Hepatitis C virus (HCV) is a major cause of chronic liver di...... Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis. More... |
| hsa04630 | Jak-STAT signaling pathway | 22 | The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More... |
| hsa05162 | Measles | 20 | Measles virus (MV) is highly contagious virus that leads inf...... Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. More... |
Genes shared at least 5 GO terms with IRF9 (count: 33)
Genes shared at least 2 KEGG pathways with IRF9 (count: 14)
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Region: chr14:24630262..24635774 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014