ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	KIF2C
Previous Symbol	KNSL6
Symbol Alias	MCAK
Approved Name	kinesin family member 2C
Previous Name	kinesin-like 6 (mitotic centromere-associated kinesin)
Location	1p34.1
Position	chr1:45205490-45233439, +
External Links	HGNC: 6393 Entrez Gene: 11004 Ensembl: ENSG00000142945 UCSC: uc001cmg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 26)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000087	M phase of mitotic cell cycle	Biological Process		19
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0000236	mitotic prometaphase	Biological Process		17
GO:0005634	nucleus	Cellular Component		770
GO:0005829	cytosol	Cellular Component		447
GO:0005515	protein binding	Molecular Function	IPI[19632184]	910
GO:0005524	ATP binding	Molecular Function		228
GO:0000777	condensed chromosome kinetochore	Cellular Component		13
GO:0003777	microtubule motor activity	Molecular Function		17
GO:0000775	chromosome, centromeric region	Cellular Component	IDA[14960279]	9
GO:0000776	kinetochore	Cellular Component	IDA[14960279]	15
GO:0007596	blood coagulation	Biological Process		83
GO:0008283	cell proliferation	Biological Process	TAS[9434124]	60
GO:0007059	chromosome segregation	Biological Process		14
GO:0007067	mitosis	Biological Process	TAS[9434124]	39
GO:0007018	microtubule-based movement	Biological Process		20
GO:0007019	microtubule depolymerization	Biological Process	IMP[19060894]	2
GO:0005871	kinesin complex	Cellular Component	TAS[9434124]	5
GO:0005881	cytoplasmic microtubule	Cellular Component		8
GO:0051983	regulation of chromosome segregation	Biological Process	IMP[19060894]	1
GO:0051301	cell division	Biological Process		58
GO:0051010	microtubule plus-end binding	Molecular Function	IDA[19632184]	5
GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity	Biological Process	IMP[14718566]	2
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Biological Process		14
GO:0019237	centromeric DNA binding	Molecular Function	TAS[9434124]	3
GO:0015630	microtubule cytoskeleton	Cellular Component		34

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with KIF2C (count: 51)

Gene Symbol	Pathway Count	Pathway List
KIF23	12	microtubule cytoskeleton organization; M phase of mitotic cell cycle; mitotic cell cycle; nucleus; cytosol; protein binding; ATP binding; microtubule motor activity; blood coagulation; microtubule-based movement; kinesin complex; antigen processing and presentation of exogenous peptide antigen via MHC class II;
CLASP1	11	microtubule cytoskeleton organization; M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; protein binding; condensed chromosome kinetochore; kinetochore; cytoplasmic microtubule; cell division; microtubule plus-end binding;
SMC1A	11	microtubule cytoskeleton organization; M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; nucleus; protein binding; ATP binding; condensed chromosome kinetochore; microtubule motor activity; kinetochore; cell division;
SMC3	11	microtubule cytoskeleton organization; M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; nucleus; protein binding; ATP binding; microtubule motor activity; chromosome, centromeric region; mitosis; cell division;
CLASP2	10	microtubule cytoskeleton organization; M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; protein binding; condensed chromosome kinetochore; cytoplasmic microtubule; cell division; microtubule plus-end binding;
KIF11	10	microtubule cytoskeleton organization; cytosol; ATP binding; microtubule motor activity; blood coagulation; mitosis; microtubule-based movement; kinesin complex; cell division; antigen processing and presentation of exogenous peptide antigen via MHC class II;
MAPRE1	10	microtubule cytoskeleton organization; M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; protein binding; cell proliferation; cytoplasmic microtubule; cell division; microtubule plus-end binding;
PLK1	10	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; nucleus; cytosol; protein binding; ATP binding; kinetochore; cell proliferation; mitosis;
ZW10	10	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; nucleus; cytosol; protein binding; condensed chromosome kinetochore; kinetochore; cell division; centromeric DNA binding;
CKAP5	9	microtubule cytoskeleton organization; M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; protein binding; cell division; establishment or maintenance of microtubule cytoskeleton polarity; microtubule cytoskeleton;
PAFAH1B1	9	microtubule cytoskeleton organization; M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; nucleus; cytosol; protein binding; kinetochore; kinesin complex;
CENPC1	9	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; nucleus; cytosol; condensed chromosome kinetochore; kinetochore; chromosome segregation; cell division;
INCENP	9	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; protein binding; condensed chromosome kinetochore; chromosome, centromeric region; kinetochore; chromosome segregation;
KIF22	9	nucleus; cytosol; ATP binding; microtubule motor activity; kinetochore; blood coagulation; mitosis; microtubule-based movement; antigen processing and presentation of exogenous peptide antigen via MHC class II;
NDE1	8	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; protein binding; condensed chromosome kinetochore; kinetochore; cell division;
CENPW	8	mitotic cell cycle; protein binding; condensed chromosome kinetochore; chromosome, centromeric region; kinetochore; chromosome segregation; mitosis; cell division;
APC	7	microtubule cytoskeleton organization; nucleus; cytosol; protein binding; kinetochore; cytoplasmic microtubule; microtubule plus-end binding;
PTTG1	7	mitotic cell cycle; nucleus; cytosol; protein binding; chromosome segregation; mitosis; cell division;
KLC2	7	cytosol; protein binding; microtubule motor activity; blood coagulation; microtubule-based movement; kinesin complex; antigen processing and presentation of exogenous peptide antigen via MHC class II;
RCC1	6	microtubule cytoskeleton organization; nucleus; protein binding; chromosome segregation; mitosis; cell division;
TUBGCP2	6	microtubule cytoskeleton organization; mitotic cell cycle; nucleus; cytosol; protein binding; cytoplasmic microtubule;
CENPL	6	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; nucleus; cytosol; chromosome, centromeric region;
XPO1	6	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; protein binding; kinetochore;
CEP164	6	mitotic cell cycle; nucleus; cytosol; protein binding; mitosis; cell division;
DCTN3	6	mitotic cell cycle; cytosol; protein binding; condensed chromosome kinetochore; mitosis; antigen processing and presentation of exogenous peptide antigen via MHC class II;
CENPV	6	nucleus; condensed chromosome kinetochore; kinetochore; mitosis; cell division; microtubule cytoskeleton;
KIFC1	6	nucleus; ATP binding; microtubule motor activity; blood coagulation; microtubule-based movement; cell division;
LATS2	6	nucleus; cytosol; protein binding; ATP binding; mitosis; cell division;
MAPK1	6	nucleus; cytosol; protein binding; ATP binding; blood coagulation; microtubule cytoskeleton;
MAPK3	6	nucleus; cytosol; protein binding; ATP binding; blood coagulation; microtubule cytoskeleton;
ARHGEF2	5	microtubule cytoskeleton organization; cytosol; protein binding; mitosis; cell division;
CDK5RAP2	5	microtubule cytoskeleton organization; mitotic cell cycle; cytosol; protein binding; chromosome segregation;
CENPJ	5	microtubule cytoskeleton organization; mitotic cell cycle; cytosol; protein binding; cell division;
RAN	5	microtubule cytoskeleton organization; cytosol; protein binding; mitosis; cell division;
CENPN	5	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; condensed chromosome kinetochore;
CENPP	5	M phase of mitotic cell cycle; mitotic cell cycle; mitotic prometaphase; cytosol; chromosome, centromeric region;
ANAPC4	5	mitotic cell cycle; nucleus; cytosol; mitosis; cell division;
CCND1	5	mitotic cell cycle; nucleus; cytosol; protein binding; cell division;
CDC26	5	mitotic cell cycle; cytosol; protein binding; mitosis; cell division;
CEP57	5	mitotic cell cycle; nucleus; cytosol; protein binding; microtubule cytoskeleton;
CSNK1E	5	mitotic cell cycle; nucleus; cytosol; protein binding; ATP binding;
NUMA1	5	mitotic cell cycle; nucleus; cytosol; protein binding; cell division;
PSMC3	5	mitotic cell cycle; nucleus; cytosol; protein binding; ATP binding;
TUBA4A	5	mitotic cell cycle; cytosol; blood coagulation; microtubule-based movement; microtubule cytoskeleton;
NEK6	5	nucleus; protein binding; ATP binding; chromosome segregation; mitosis;
PRKCB	5	nucleus; cytosol; protein binding; ATP binding; blood coagulation;
PRKD1	5	nucleus; cytosol; protein binding; ATP binding; cell proliferation;
BCAR1	5	cytosol; protein binding; blood coagulation; cell proliferation; cell division;
DYNC2H1	5	cytosol; ATP binding; microtubule motor activity; microtubule-based movement; antigen processing and presentation of exogenous peptide antigen via MHC class II;
LATS1	5	cytosol; protein binding; ATP binding; mitosis; cell division;
SYK	5	cytosol; protein binding; ATP binding; blood coagulation; cell proliferation;

Genes shared at least 2 KEGG pathways with KIF2C (count: 0)

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Region: chr1:45205490..45233439 View in gBrowse