ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	LATS1
Symbol Alias	WARTS
Approved Name	LATS, large tumor suppressor, homolog 1 (Drosophila)
Previous Name	LATS (large tumor suppressor, Drosophila) homolog 1
Location	6q25.1
Position	chr6:149982051-150039392, -
External Links	HGNC: 6514 Entrez Gene: 9113 Ensembl: ENSG00000131023 UCSC: uc003qmu.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051493	regulation of cytoskeleton organization	Biological Process		32

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005524	ATP binding	Molecular Function	IDA[10518011]	228
GO:0005515	protein binding	Molecular Function		910
GO:0004674	protein serine/threonine kinase activity	Molecular Function		61
GO:0000922	spindle pole	Cellular Component	IDA[10518011]	22
GO:0007067	mitosis	Biological Process		39
GO:0006468	protein phosphorylation	Biological Process	IDA[10518011]	53
GO:0005829	cytosol	Cellular Component		447
GO:0005815	microtubule organizing center	Cellular Component		19
GO:0030833	regulation of actin filament polymerization	Biological Process	IDA[15220930]	5
GO:0030216	keratinocyte differentiation	Biological Process		9
GO:0019901	protein kinase binding	Molecular Function	IPI[19927127]	51
GO:0009755	hormone-mediated signaling pathway	Biological Process		4
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process	IDA[9988268]	6
GO:0043254	regulation of protein complex assembly	Biological Process		1
GO:0035329	hippo signaling cascade	Biological Process		5
GO:0033138	positive regulation of peptidyl-serine phosphorylation	Biological Process		10
GO:0051220	cytoplasmic sequestering of protein	Biological Process		1
GO:0051301	cell division	Biological Process		58
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	Biological Process		14
GO:0000287	magnesium ion binding	Molecular Function	IDA[10518011]	28
GO:0000819	sister chromatid segregation	Biological Process	IDA[15122335]	1
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process	IDA[15122335]	29

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LATS1 (count: 41)

Gene Symbol	Pathway Count	Pathway List
LATS2	14	ATP binding; protein binding; protein serine/threonine kinase activity; spindle pole; mitosis; protein phosphorylation; cytosol; microtubule organizing center; keratinocyte differentiation; hormone-mediated signaling pathway; negative regulation of cyclin-dependent protein kinase activity; hippo signaling cascade; cell division; negative regulation of canonical Wnt receptor signaling pathway;
PLK1	10	ATP binding; protein binding; protein serine/threonine kinase activity; spindle pole; mitosis; protein phosphorylation; cytosol; protein kinase binding; negative regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle;
NEK6	9	ATP binding; protein binding; protein serine/threonine kinase activity; spindle pole; mitosis; protein phosphorylation; microtubule organizing center; protein kinase binding; magnesium ion binding;
GSK3B	8	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; cytosol; protein kinase binding; positive regulation of peptidyl-serine phosphorylation; negative regulation of canonical Wnt receptor signaling pathway;
PAK1	7	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; cytosol; protein kinase binding; positive regulation of peptidyl-serine phosphorylation;
CDC25B	7	spindle pole; mitosis; protein phosphorylation; cytosol; protein kinase binding; cell division; G2/M transition of mitotic cell cycle;
CSNK1E	6	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; cytosol; G2/M transition of mitotic cell cycle;
ILK	6	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; cytosol; protein kinase binding;
KIF11	6	ATP binding; spindle pole; mitosis; cytosol; protein kinase binding; cell division;
MAPK1	6	ATP binding; protein binding; protein serine/threonine kinase activity; cytosol; microtubule organizing center; regulation of cytoskeleton organization;
MARK2	6	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; regulation of cytoskeleton organization; magnesium ion binding;
APC	6	protein binding; cytosol; protein kinase binding; negative regulation of cyclin-dependent protein kinase activity; regulation of cytoskeleton organization; negative regulation of canonical Wnt receptor signaling pathway;
BIRC6	6	protein binding; spindle pole; mitosis; protein phosphorylation; microtubule organizing center; cell division;
CEP250	6	protein binding; cytosol; microtubule organizing center; protein kinase binding; regulation of cytoskeleton organization; G2/M transition of mitotic cell cycle;
CDC42BPG	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; magnesium ion binding;
CHEK1	5	ATP binding; protein binding; protein serine/threonine kinase activity; cytosol; G2/M transition of mitotic cell cycle;
KIF2C	5	ATP binding; protein binding; mitosis; cytosol; cell division;
MAP2K3	5	ATP binding; protein binding; protein serine/threonine kinase activity; cytosol; protein kinase binding;
MAPK3	5	ATP binding; protein binding; protein phosphorylation; cytosol; regulation of cytoskeleton organization;
MARK4	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; microtubule organizing center;
PRKCB	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; cytosol;
PRKD1	5	ATP binding; protein binding; protein serine/threonine kinase activity; cytosol; positive regulation of peptidyl-serine phosphorylation;
ROCK2	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; cytosol;
RPS6KA4	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; magnesium ion binding;
SIK2	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; magnesium ion binding;
SIK3	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; magnesium ion binding;
SMC3	5	ATP binding; protein binding; spindle pole; mitosis; cell division;
STK36	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; magnesium ion binding;
SYK	5	ATP binding; protein binding; protein phosphorylation; cytosol; protein kinase binding;
TSSK2	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; magnesium ion binding;
TSSK4	5	ATP binding; protein binding; protein serine/threonine kinase activity; protein phosphorylation; magnesium ion binding;
ARHGEF2	5	protein binding; mitosis; cytosol; cell division; regulation of cytoskeleton organization;
CDK5RAP2	5	protein binding; spindle pole; cytosol; protein kinase binding; G2/M transition of mitotic cell cycle;
CENPJ	5	protein binding; cytosol; protein kinase binding; cell division; G2/M transition of mitotic cell cycle;
CEP164	5	protein binding; mitosis; cytosol; cell division; G2/M transition of mitotic cell cycle;
CKAP5	5	protein binding; spindle pole; cytosol; cell division; G2/M transition of mitotic cell cycle;
CLASP1	5	protein binding; cytosol; cell division; regulation of cytoskeleton organization; G2/M transition of mitotic cell cycle;
CLASP2	5	protein binding; cytosol; microtubule organizing center; cell division; regulation of cytoskeleton organization;
MAPRE1	5	protein binding; cytosol; cell division; regulation of cytoskeleton organization; G2/M transition of mitotic cell cycle;
NUMA1	5	protein binding; spindle pole; cytosol; cell division; G2/M transition of mitotic cell cycle;
TUBGCP2	5	protein binding; spindle pole; cytosol; microtubule organizing center; G2/M transition of mitotic cell cycle;

Genes shared at least 2 KEGG pathways with LATS1 (count: 0)

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Region: chr6:149982051..150039392 View in gBrowse