ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MEIS2
Symbol Alias	MRG1, HsT18361
Approved Name	Meis homeobox 2
Previous Name	Meis (mouse) homolog 2, "Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)"
Location	15q14
Position	chr15:37183222-37393500, -
External Links	HGNC: 7001 Entrez Gene: 4212 Ensembl: ENSG00000134138 UCSC: uc001zjr.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lasky-Su J, 2008	1 flanking SNPs of this gene with P-value<1E-5.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs8041675	Chr15:37342602(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003714	transcription corepressor activity	Molecular Function	TAS[10764806]	29
GO:0005515	protein binding	Molecular Function	IPI[19559479]	910
GO:0005634	nucleus	Cellular Component		770
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[10764806]	62
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[10764806]	78
GO:0001654	eye development	Biological Process		2
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003712	transcription cofactor activity	Molecular Function		17
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0045638	negative regulation of myeloid cell differentiation	Biological Process		3
GO:0043565	sequence-specific DNA binding	Molecular Function	IDA[17178831]	72
GO:0008134	transcription factor binding	Molecular Function		38

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MEIS2 (count: 38)

Gene Symbol	Pathway Count	Pathway List
NCOR1	7	transcription corepressor activity; protein binding; nucleus; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
ETS1	7	protein binding; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
GATA6	7	protein binding; nucleus; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding;
HES1	7	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
HEY2	7	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
DRAP1	6	transcription corepressor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; transcription factor binding;
HNF1B	6	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
KDM1A	6	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding;
MED1	6	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; transcription cofactor activity; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding;
MTA2	6	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
RELA	6	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
SREBF1	6	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
TFAP2A	6	protein binding; nucleus; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
FOXC2	6	nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
FOXE1	6	nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
HOXA7	6	nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
MAF	6	nucleus; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
FEV	5	transcription corepressor activity; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
LHX1	5	transcription corepressor activity; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
NFIL3	5	transcription corepressor activity; nucleus; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
NRIP1	5	transcription corepressor activity; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
SNW1	5	transcription corepressor activity; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
ARRB1	5	protein binding; nucleus; transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; transcription factor binding;
CREB5	5	protein binding; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXG1	5	protein binding; nucleus; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
HOXA1	5	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA5	5	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA9	5	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of myeloid cell differentiation; sequence-specific DNA binding;
IRF7	5	protein binding; nucleus; transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MEN1	5	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
MLL	5	protein binding; nucleus; transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
POU2F3	5	protein binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
RBPJ	5	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
STRN3	5	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter;
FOXD4	5	nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
FOXF1	5	nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription factor binding;
HOXA2	5	nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
IKZF1	5	nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with MEIS2 (count: 0)

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Region: chr15:37183222..37393500 View in gBrowse