ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MTA2
Previous Symbol	MTA1L1
Symbol Alias	MTA1-L1
Approved Name	metastasis associated 1 family, member 2
Previous Name	metastasis associated gene family, member 2
Location	11q12-q13.1
Position	chr11:62360675-62369312, -
External Links	HGNC: 7411 Entrez Gene: 9219 Ensembl: ENSG00000149480 UCSC: uc001ntq.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044212	transcription regulatory region DNA binding	Molecular Function		23
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0016581	NuRD complex	Cellular Component	IDA[19644445]	2
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0006333	chromatin assembly or disassembly	Biological Process	TAS[10444591]	2
GO:0008270	zinc ion binding	Molecular Function		323
GO:0000118	histone deacetylase complex	Cellular Component	TAS[10444591]	5
GO:0000989	transcription factor binding transcription factor activity	Molecular Function		1
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0001103	RNA polymerase II repressing transcription factor binding	Molecular Function		4
GO:0001085	RNA polymerase II transcription factor binding	Molecular Function	IPI[15920471]	10
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function		132
GO:0003682	chromatin binding	Molecular Function		48
GO:0005515	protein binding	Molecular Function		910
GO:0004407	histone deacetylase activity	Molecular Function		1
GO:0005667	transcription factor complex	Cellular Component	IDA[15920471]	51
GO:0005634	nucleus	Cellular Component		770
GO:0006306	DNA methylation	Biological Process		1
GO:0005730	nucleolus	Cellular Component		243

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MTA2 (count: 69)

Gene Symbol	Pathway Count	Pathway List
GATA6	10	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II repressing transcription factor binding; sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; transcription factor complex; nucleus;
HNF1B	9	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor complex; nucleus; nucleolus;
KDM1A	9	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; transcription factor complex; nucleus;
NCOR1	9	transcription regulatory region DNA binding; sequence-specific DNA binding; histone deacetylase complex; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; transcription factor complex; nucleus;
MEN1	8	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; nucleolus;
RELA	8	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; transcription factor complex; nucleus;
TFAP2A	8	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; nucleolus;
FOXC2	7	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus;
HINFP	7	transcription regulatory region DNA binding; zinc ion binding; sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; nucleus; nucleolus;
KLF4	7	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; sequence-specific DNA binding transcription factor activity; transcription factor complex;
FOXP1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; chromatin binding; transcription factor complex; nucleus; nucleolus;
POU2F3	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor complex; nucleus; nucleolus;
RBPJ	7	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II repressing transcription factor binding; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; nucleolus;
SREBF1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; nucleus;
MTA3	7	NuRD complex; sequence-specific DNA binding; zinc ion binding; sequence-specific DNA binding transcription factor activity; chromatin binding; nucleus; nucleolus;
FOXF1	6	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus;
MLL	6	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
YAP1	6	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; transcription factor complex; nucleus;
CBFA2T3	6	positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding; nucleolus;
ETS1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor complex; nucleus;
FOXD4	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; nucleolus;
FOXE1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus;
HES1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
HEY2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
HOXA2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus; nucleolus;
IKZF1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
ISL1	6	positive regulation of transcription from RNA polymerase II promoter; zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; chromatin binding; nucleus;
KAT5	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; protein binding; transcription factor complex; nucleus; nucleolus;
MED1	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; nucleolus;
MEIS2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
NCOA6	6	positive regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; transcription factor complex; nucleus; nucleolus;
NR5A1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; chromatin binding; protein binding; nucleus;
GFI1B	6	zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; protein binding; transcription factor complex; nucleus;
RNF2	6	zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; nucleolus;
HOXA13	5	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus;
KLF11	5	transcription regulatory region DNA binding; zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
TFEB	5	transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus;
AATF	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; nucleolus;
BARX2	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; chromatin binding; transcription factor complex;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus;
CLOCK	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; transcription factor complex; nucleus; nucleolus;
ESRRA	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; protein binding; nucleus;
FOXG1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; protein binding; transcription factor complex; nucleus;
GSK3B	5	positive regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; protein binding; nucleus; nucleolus;
HOXA1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
HOXA5	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
HOXA7	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
HOXB1	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; nucleus; nucleolus;
LHX2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; sequence-specific DNA binding transcription factor activity; nucleus;
LPIN1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; transcription factor complex; nucleus;
MAF	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
MYB	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; chromatin binding; protein binding;
NR4A2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; protein binding; nucleus;
NRIP1	5	positive regulation of transcription from RNA polymerase II promoter; histone deacetylase complex; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus;
RBM14	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; transcription factor complex; nucleus; nucleolus;
RORA	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; zinc ion binding; sequence-specific DNA binding transcription factor activity; protein binding;
SNW1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleolus;
SPI1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; sequence-specific DNA binding transcription factor activity; protein binding;
STRN3	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
CREB5	5	sequence-specific DNA binding; zinc ion binding; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
FOXP2	5	sequence-specific DNA binding; zinc ion binding; sequence-specific DNA binding transcription factor activity; chromatin binding; transcription factor complex;
HOXA9	5	sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; protein binding; transcription factor complex; nucleus;
LMX1B	5	sequence-specific DNA binding; zinc ion binding; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
PGR	5	sequence-specific DNA binding; zinc ion binding; protein binding; nucleus; nucleolus;
PRDM1	5	sequence-specific DNA binding; zinc ion binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; nucleus;
ZNF24	5	sequence-specific DNA binding; zinc ion binding; sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
RNF20	5	zinc ion binding; chromatin binding; protein binding; nucleus; nucleolus;
NCOR2	5	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; protein binding; nucleus; nucleolus;
TCF25	5	negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein binding; nucleus; nucleolus;

Genes shared at least 2 KEGG pathways with MTA2 (count: 0)

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Region: chr11:62360675..62369312 View in gBrowse