ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MTA3
Symbol Alias	KIAA1266
Approved Name	metastasis associated 1 family, member 3
Previous Name	metastasis associated gene family, member 3
Location	2p22.1
Position	chr2:42721709-42984087, +
External Links	HGNC: 23784 Entrez Gene: 57504 Ensembl: ENSG00000057935 UCSC: uc002rsq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 18)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6719977	Chr2:42985803(Fwd)	downstream_gene_variant	1(0/0/1)
rs930421	Chr2:42981239(Fwd)	3_prime_UTR_variant; downstream_gene_variant	1(0/0/1)

LD-proxies (count: 16)

rs_ID	Location	Functional Annotation
rs1016607	Chr2:42971687(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4953631	Chr2:42970990(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs6544594	Chr2:42977579(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs6713059	Chr2:42977280(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs1971138	Chr2:42969270(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7578904	Chr2:42984490(Fwd)	downstream_gene_variant
rs2289355	Chr2:42981990(Fwd)	3_prime_UTR_variant; downstream_gene_variant
rs7566714	Chr2:42984707(Fwd)	downstream_gene_variant
rs11681208	Chr2:42987268(Fwd)	downstream_gene_variant
rs10205149	Chr2:42977733(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs930420	Chr2:42978436(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs10185815	Chr2:42973439(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs13389948	Chr2:42974576(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs7591304	Chr2:42977799(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs6544595	Chr2:42977870(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4953636	Chr2:42980069(Fwd)	NMD_transcript_variant; feature_truncation; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	No. of Genes in ADHDgene
GO:0003682	chromatin binding	Molecular Function	48
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	132
GO:0043565	sequence-specific DNA binding	Molecular Function	72
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	62
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	Biological Process	1
GO:0016581	NuRD complex	Cellular Component	2
GO:0008278	cohesin complex	Cellular Component	3
GO:0008284	positive regulation of cell proliferation	Biological Process	69
GO:0005737	cytoplasm	Cellular Component	690
GO:0008270	zinc ion binding	Molecular Function	323
GO:0005634	nucleus	Cellular Component	770
GO:0005730	nucleolus	Cellular Component	243

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MTA3 (count: 22)

Gene Symbol	Pathway Count	Pathway List
MTA2	7	chromatin binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; NuRD complex; zinc ion binding; nucleus; nucleolus;
FOXP1	6	chromatin binding; sequence-specific DNA binding; cytoplasm; zinc ion binding; nucleus; nucleolus;
ISL1	6	chromatin binding; sequence-specific DNA binding transcription factor activity; positive regulation of cell proliferation; cytoplasm; zinc ion binding; nucleus;
RELA	6	chromatin binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of cell proliferation; cytoplasm; nucleus;
TFAP2A	6	chromatin binding; sequence-specific DNA binding; intracellular membrane-bounded organelle; cytoplasm; nucleus; nucleolus;
PGR	6	sequence-specific DNA binding; intracellular membrane-bounded organelle; cytoplasm; zinc ion binding; nucleus; nucleolus;
CDCA5	5	chromatin binding; cohesin complex; cytoplasm; nucleus; nucleolus;
FOXP2	5	chromatin binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; cytoplasm; zinc ion binding;
HINFP	5	chromatin binding; sequence-specific DNA binding transcription factor activity; zinc ion binding; nucleus; nucleolus;
MEN1	5	chromatin binding; sequence-specific DNA binding; cytoplasm; nucleus; nucleolus;
NCOR1	5	chromatin binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; cytoplasm; nucleus;
HES1	5	sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of cell proliferation; cytoplasm; nucleus;
HOXA3	5	sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of cell proliferation; nucleus; nucleolus;
HOXB1	5	sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; cytoplasm; nucleus; nucleolus;
IKZF1	5	sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; cytoplasm; zinc ion binding; nucleus;
POU2F3	5	sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; cytoplasm; nucleus; nucleolus;
PRDM1	5	sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; cytoplasm; zinc ion binding; nucleus;
TRIM22	5	sequence-specific DNA binding transcription factor activity; intracellular membrane-bounded organelle; cytoplasm; zinc ion binding; nucleus;
ZNF263	5	sequence-specific DNA binding transcription factor activity; cytoplasm; zinc ion binding; nucleus; nucleolus;
ZNF367	5	sequence-specific DNA binding transcription factor activity; cytoplasm; zinc ion binding; nucleus; nucleolus;
DPF2	5	intracellular membrane-bounded organelle; cytoplasm; zinc ion binding; nucleus; nucleolus;
SLU7	5	intracellular membrane-bounded organelle; cytoplasm; zinc ion binding; nucleus; nucleolus;

Genes shared at least 2 KEGG pathways with MTA3 (count: 0)

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Region: chr2:42721709..42984087 View in gBrowse