ADHDgene Database

Gene Report

Basic Info

Approved Symbol	NAPRT1
Symbol Alias	PP3856
Approved Name	nicotinate phosphoribosyltransferase domain containing 1
Location	8q24.3
Position	chr8:144656955-144660819, -
External Links	HGNC: 30450 Entrez Gene: 93100 Ensembl: ENSG00000147813 UCSC: uc003yym.3
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lasky-Su J, 2008	1 flanking SNPs of this gene with P-value<1E-5.	Trend

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2290416	Chr8:144657600(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs3793371	Chr8:144664299(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004516	nicotinate phosphoribosyltransferase activity	Molecular Function	IDA[17604275]	1
GO:0005634	nucleus	Cellular Component		770
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	Molecular Function		2
GO:0006979	response to oxidative stress	Biological Process	IMP[17604275]	17
GO:0009435	NAD biosynthetic process	Biological Process		6
GO:0006767	water-soluble vitamin metabolic process	Biological Process		13
GO:0006769	nicotinamide metabolic process	Biological Process		1
GO:0005829	cytosol	Cellular Component	IDA[17604275]	447
GO:0006766	vitamin metabolic process	Biological Process		13
GO:0005737	cytoplasm	Cellular Component		690
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0019674	NAD metabolic process	Biological Process		5
GO:0019358	nicotinate nucleotide salvage	Biological Process		1
GO:0044281	small molecule metabolic process	Biological Process		248

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00760	Nicotinate and nicotinamide metabolism	9

Genes shared at least 5 GO terms with NAPRT1 (count: 7)

Gene Symbol	Pathway Count	Pathway List
NMNAT2	8	nucleus; NAD biosynthetic process; water-soluble vitamin metabolic process; vitamin metabolic process; cytoplasm; Golgi apparatus; NAD metabolic process; small molecule metabolic process;
QPRT	7	nicotinate-nucleotide diphosphorylase (carboxylating) activity; NAD biosynthetic process; water-soluble vitamin metabolic process; cytosol; vitamin metabolic process; NAD metabolic process; small molecule metabolic process;
SHMT1	6	nucleus; water-soluble vitamin metabolic process; cytosol; vitamin metabolic process; cytoplasm; small molecule metabolic process;
NADSYN1	6	NAD biosynthetic process; water-soluble vitamin metabolic process; cytosol; vitamin metabolic process; NAD metabolic process; small molecule metabolic process;
NMNAT3	6	NAD biosynthetic process; water-soluble vitamin metabolic process; cytosol; vitamin metabolic process; NAD metabolic process; small molecule metabolic process;
FABP6	5	nucleus; cytosol; cytoplasm; Golgi apparatus; small molecule metabolic process;
PRKD1	5	nucleus; cytosol; cytoplasm; Golgi apparatus; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with NAPRT1 (count: 8)

Gene Symbol	Pathway Count	Pathway List
ENPP1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
ENPP3	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NADSYN1	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT2	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NMNAT3	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NNMT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
NT5M	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;
QPRT	2	Metabolic pathways; Nicotinate and nicotinamide metabolism;

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Region: chr8:144656955..144660819 View in gBrowse