ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NR4A2
Previous Symbol	NURR1
Symbol Alias	TINUR, NOT, RNR1, HZF-3
Approved Name	nuclear receptor subfamily 4, group A, member 2
Location	2q22-q23
Position	chr2:157180944-157198860, -
External Links	HGNC: 7981 Entrez Gene: 4929 Ensembl: ENSG00000153234 UCSC: uc002tyz.3
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

Gene related studies (count: 2)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.0959, global P-value=0.665, WHAP TDT P_sum P-value=0.591, no SNP with nominal P-value<0.05 located in this gene	Non-significant
Smith KM, 2005	no association with the haplotypes (TDT P-value>0.24) or polymorphisms was detected	Non-significant

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (significant/non-significant/trend)
NR4A2_upstream_deltaC_BglI	point mutation	254bp upstream from the transcriptional start site, and creates a restriction digest site for BglI	1 (0/1/0)
NR4A2_3'-UTR_(CA)n	microsatellite	3' UTR	1 (0/1/0)

Gene related regions (count: 0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001666	response to hypoxia	Biological Process		34
GO:0001764	neuron migration	Biological Process		21
GO:0001975	response to amphetamine	Biological Process		16
GO:0003707	steroid hormone receptor activity	Molecular Function		9
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	Molecular Function		6
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component	IDA[17184956]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component		690
GO:0006351	transcription, DNA-dependent	Biological Process	IDA[17184956]	247
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0007165	signal transduction	Biological Process	NAS[7877627]	171
GO:0008270	zinc ion binding	Molecular Function		323
GO:0008344	adult locomotory behavior	Biological Process		12
GO:0071542	dopaminergic neuron differentiation	Biological Process		3
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0043576	regulation of respiratory gaseous exchange	Biological Process		2
GO:0043524	negative regulation of neuron apoptotic process	Biological Process		19
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0042551	neuron maturation	Biological Process		2
GO:0043085	positive regulation of catalytic activity	Biological Process		7
GO:0042053	regulation of dopamine metabolic process	Biological Process		5
GO:0042416	dopamine biosynthetic process	Biological Process		5
GO:0031668	cellular response to extracellular stimulus	Biological Process	IDA[7877627]	2
GO:0033554	cellular response to stress	Biological Process		12
GO:0021986	habenula development	Biological Process		1
GO:0030522	intracellular receptor mediated signaling pathway	Biological Process	TAS[7877627]	6
GO:0017085	response to insecticide	Biological Process		1
GO:0021952	central nervous system projection neuron axonogenesis	Biological Process		2
GO:0010467	gene expression	Biological Process		140
GO:0016265	death	Biological Process		2
GO:0009791	post-embryonic development	Biological Process		16
GO:0010035	response to inorganic substance	Biological Process		2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NR4A2 (count: 108)

Gene Symbol	Pathway Count	Pathway List
ESRRA	11	steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; intracellular receptor mediated signaling pathway; gene expression;
NR5A1	11	steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; intracellular receptor mediated signaling pathway; gene expression;
PGR	11	steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; nucleus; nucleoplasm; cytoplasm; transcription initiation from RNA polymerase II promoter; signal transduction; zinc ion binding; sequence-specific DNA binding; gene expression;
RORA	11	steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; signal transduction; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; intracellular receptor mediated signaling pathway; gene expression;
NR4A3	9	steroid hormone receptor activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; zinc ion binding; negative regulation of neuron apoptotic process; sequence-specific DNA binding; cellular response to stress; gene expression;
MEN1	9	protein binding; nucleus; nucleoplasm; cytoplasm; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; gene expression;
NR3C2	8	steroid hormone receptor activity; protein binding; nucleoplasm; transcription initiation from RNA polymerase II promoter; signal transduction; zinc ion binding; sequence-specific DNA binding; gene expression;
NR6A1	8	steroid hormone receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleoplasm; transcription initiation from RNA polymerase II promoter; zinc ion binding; sequence-specific DNA binding; intracellular receptor mediated signaling pathway; gene expression;
NCOR1	8	protein binding; nucleus; nucleoplasm; cytoplasm; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; sequence-specific DNA binding; gene expression;
VEGFA	7	response to hypoxia; protein binding; cytoplasm; dopaminergic neuron differentiation; protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; cellular response to stress;
ATXN1	7	protein binding; nucleus; nucleoplasm; cytoplasm; transcription, DNA-dependent; adult locomotory behavior; positive regulation of transcription from RNA polymerase II promoter;
E2F5	7	protein binding; nucleoplasm; cytoplasm; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
NEDD4L	7	protein binding; nucleus; nucleoplasm; cytoplasm; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; gene expression;
RBPJ	7	protein binding; nucleus; nucleoplasm; cytoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
SNCA	7	protein binding; nucleus; cytoplasm; zinc ion binding; adult locomotory behavior; negative regulation of neuron apoptotic process; dopamine biosynthetic process;
UBB	7	protein binding; nucleoplasm; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; cellular response to stress; gene expression;
UBC	7	protein binding; nucleoplasm; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; cellular response to stress; gene expression;
YAP1	7	protein binding; nucleus; nucleoplasm; cytoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
IKZF1	7	nucleus; cytoplasm; transcription, DNA-dependent; zinc ion binding; protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
BNIP3	6	response to hypoxia; protein binding; nucleus; nucleoplasm; cytoplasm; protein heterodimerization activity;
EGLN3	6	response to hypoxia; protein binding; nucleus; nucleoplasm; cytoplasm; cellular response to stress;
ETS1	6	response to hypoxia; protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
TH	6	response to hypoxia; response to amphetamine; protein binding; nucleus; cytoplasm; dopamine biosynthetic process;
APBB1	6	neuron migration; protein binding; nucleus; cytoplasm; transcription, DNA-dependent; signal transduction;
ATF6	6	protein binding; nucleus; nucleoplasm; transcription, DNA-dependent; signal transduction; sequence-specific DNA binding;
FUS	6	protein binding; nucleus; nucleoplasm; cytoplasm; zinc ion binding; gene expression;
LPXN	6	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; signal transduction; zinc ion binding;
MAML1	6	protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
MAPK1	6	protein binding; nucleus; nucleoplasm; cytoplasm; transcription, DNA-dependent; signal transduction;
MED1	6	protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
NCOR2	6	protein binding; nucleus; nucleoplasm; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; gene expression;
POU2F3	6	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
PRKCB	6	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; signal transduction; zinc ion binding;
RBM4	6	protein binding; nucleus; nucleoplasm; cytoplasm; zinc ion binding; cellular response to stress;
RELA	6	protein binding; nucleus; nucleoplasm; cytoplasm; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
SMC1A	6	protein binding; nucleus; nucleoplasm; cytoplasm; protein heterodimerization activity; gene expression;
SMC3	6	protein binding; nucleus; nucleoplasm; cytoplasm; signal transduction; protein heterodimerization activity;
SNW1	6	protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
TAF10	6	protein binding; nucleus; nucleoplasm; cytoplasm; transcription initiation from RNA polymerase II promoter; gene expression;
TAF13	6	protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; protein heterodimerization activity; gene expression;
BCL11A	6	nucleus; cytoplasm; transcription, DNA-dependent; zinc ion binding; protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter;
FOXP1	6	nucleus; cytoplasm; zinc ion binding; protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
TAF4B	6	nucleus; nucleoplasm; cytoplasm; transcription initiation from RNA polymerase II promoter; protein heterodimerization activity; gene expression;
PRKAA1	5	response to hypoxia; protein binding; nucleus; transcription, DNA-dependent; signal transduction;
LHX1	5	neuron migration; nucleus; zinc ion binding; sequence-specific DNA binding; post-embryonic development;
PAFAH1B1	5	neuron migration; protein binding; nucleus; cytoplasm; adult locomotory behavior;
PPP1R1B	5	response to amphetamine; nucleus; cytoplasm; transcription, DNA-dependent; signal transduction;
BARD1	5	protein binding; nucleus; cytoplasm; zinc ion binding; protein heterodimerization activity;
CBFA2T3	5	protein binding; nucleoplasm; transcription, DNA-dependent; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter;
CD2BP2	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
CTNND2	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; signal transduction;
DGCR8	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
DHX9	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
EEF1D	5	protein binding; nucleus; transcription, DNA-dependent; signal transduction; gene expression;
EFTUD2	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
ERBB2	5	protein binding; nucleus; transcription, DNA-dependent; signal transduction; protein heterodimerization activity;
GATA6	5	protein binding; nucleus; nucleoplasm; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter;
HES1	5	protein binding; nucleus; cytoplasm; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HEY2	5	protein binding; nucleus; cytoplasm; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HINFP	5	protein binding; nucleus; nucleoplasm; transcription, DNA-dependent; zinc ion binding;
HNF1B	5	protein binding; nucleus; protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HNRNPA2B1	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
HNRNPH1	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
HOXA1	5	protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA5	5	protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXA9	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; sequence-specific DNA binding;
IGHMBP2	5	protein binding; nucleus; cytoplasm; transcription, DNA-dependent; zinc ion binding;
IRF7	5	protein binding; nucleus; nucleoplasm; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
KDM1A	5	protein binding; nucleus; nucleoplasm; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
LMX1B	5	protein binding; nucleus; transcription, DNA-dependent; zinc ion binding; sequence-specific DNA binding;
MAPK3	5	protein binding; nucleus; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; gene expression;
MAPK7	5	protein binding; nucleus; nucleoplasm; signal transduction; positive regulation of transcription from RNA polymerase II promoter;
MED15	5	protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression;
MED30	5	protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression;
MED4	5	protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression;
MTA2	5	protein binding; nucleus; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
NCOA6	5	protein binding; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
PARK2	5	protein binding; nucleus; cytoplasm; zinc ion binding; negative regulation of neuron apoptotic process;
PRKD1	5	protein binding; nucleus; cytoplasm; signal transduction; positive regulation of transcription from RNA polymerase II promoter;
PRPF6	5	protein binding; nucleus; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter; gene expression;
PSMC3	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
PYGO1	5	protein binding; nucleus; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; post-embryonic development;
RAN	5	protein binding; nucleoplasm; cytoplasm; signal transduction; gene expression;
RFWD2	5	protein binding; nucleus; nucleoplasm; cytoplasm; zinc ion binding;
SF3A3	5	protein binding; nucleus; nucleoplasm; zinc ion binding; gene expression;
SMARCB1	5	protein binding; nucleus; nucleoplasm; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter;
SMARCD3	5	protein binding; nucleus; nucleoplasm; cytoplasm; transcription, DNA-dependent;
SREBF1	5	protein binding; nucleus; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
SSRP1	5	protein binding; nucleus; nucleoplasm; cytoplasm; gene expression;
STRN3	5	protein binding; nucleus; nucleoplasm; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
TERF2IP	5	protein binding; nucleus; nucleoplasm; cytoplasm; transcription, DNA-dependent;
TFAP2A	5	protein binding; nucleus; cytoplasm; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
TP53BP1	5	protein binding; nucleus; nucleoplasm; cytoplasm; positive regulation of transcription from RNA polymerase II promoter;
U2AF1	5	protein binding; nucleus; nucleoplasm; zinc ion binding; gene expression;
XRCC5	5	protein binding; nucleus; nucleoplasm; cytoplasm; transcription, DNA-dependent;
ZNF24	5	protein binding; nucleus; transcription, DNA-dependent; zinc ion binding; sequence-specific DNA binding;
BSX	5	nucleus; cytoplasm; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
HOXB1	5	nucleus; cytoplasm; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
ISL1	5	nucleus; cytoplasm; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron apoptotic process;
LHX2	5	nucleus; transcription, DNA-dependent; zinc ion binding; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding;
MAML2	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
MED12	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
MED13	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
MED14	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
MED17	5	nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; gene expression;
PRDM1	5	nucleus; cytoplasm; transcription, DNA-dependent; zinc ion binding; sequence-specific DNA binding;
TFEB	5	nucleus; cytoplasm; transcription, DNA-dependent; protein heterodimerization activity; positive regulation of transcription from RNA polymerase II promoter;
FOXP2	5	cytoplasm; zinc ion binding; protein heterodimerization activity; sequence-specific DNA binding; post-embryonic development;

Genes shared at least 2 KEGG pathways with NR4A2 (count: 0)

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Region: chr2:157180944..157198860 View in gBrowse