ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	P2RX3
Symbol Alias	P2X3
Approved Name	purinergic receptor P2X, ligand-gated ion channel, 3
Location	11q12
Position	chr11:57105848-57138073, +
External Links	HGNC: 8534 Entrez Gene: 5024 Ensembl: ENSG00000109991 UCSC: uc001nju.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 30)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 30)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043025	neuronal cell body	Cellular Component		51
GO:0035590	purinergic nucleotide receptor signaling pathway	Biological Process	NAS[17895406]	2
GO:0033198	response to ATP	Biological Process		4
GO:0030432	peristalsis	Biological Process		4
GO:0019228	regulation of action potential in neuron	Biological Process		4
GO:0016020	membrane	Cellular Component		139
GO:0014832	urinary bladder smooth muscle contraction	Biological Process		2
GO:0010524	positive regulation of calcium ion transport into cytosol	Biological Process	NAS[17895406]	3
GO:0051260	protein homooligomerization	Biological Process		34
GO:0050909	sensory perception of taste	Biological Process		3
GO:0050850	positive regulation of calcium-mediated signaling	Biological Process	NAS[17895406]	7
GO:0048266	behavioral response to pain	Biological Process		4
GO:0048167	regulation of synaptic plasticity	Biological Process		9
GO:0045121	membrane raft	Cellular Component		22
GO:0043197	dendritic spine	Cellular Component		12
GO:0043195	terminal bouton	Cellular Component		11
GO:0004931	extracellular ATP-gated cation channel activity	Molecular Function	NAS[17895406]	2
GO:0005524	ATP binding	Molecular Function	NAS[17895406]	228
GO:0005791	rough endoplasmic reticulum	Cellular Component		7
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0001614	purinergic nucleotide receptor activity	Molecular Function	NAS[17895406]	2
GO:0001666	response to hypoxia	Biological Process		34
GO:0007274	neuromuscular synaptic transmission	Biological Process		5
GO:0009408	response to heat	Biological Process		7
GO:0009409	response to cold	Biological Process		8
GO:0009743	response to carbohydrate stimulus	Biological Process		1
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9221902]	220
GO:0006810	transport	Biological Process	TAS[9221902]	62
GO:0006812	cation transport	Biological Process		8
GO:0007165	signal transduction	Biological Process	TAS[9221902]	171

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with P2RX3 (count: 4)

Gene Symbol	Pathway Count	Pathway List
P2RX6	10	neuronal cell body; purinergic nucleotide receptor signaling pathway; protein homooligomerization; extracellular ATP-gated cation channel activity; ATP binding; purinergic nucleotide receptor activity; integral to plasma membrane; transport; cation transport; signal transduction;
DRD4	5	neuronal cell body; membrane; dendritic spine; terminal bouton; integral to plasma membrane;
ABCC1	5	membrane; ATP binding; Golgi apparatus; integral to plasma membrane; transport;
GJA1	5	membrane raft; Golgi apparatus; integral to plasma membrane; transport; signal transduction;

Genes shared at least 2 KEGG pathways with P2RX3 (count: 30)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

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Region: chr11:57105848..57138073 View in gBrowse