ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	P2RX6
Previous Symbol	P2RXL1
Symbol Alias	P2XM, MGC129625, P2X6
Approved Name	purinergic receptor P2X, ligand-gated ion channel, 6
Previous Name	purinergic receptor P2X-like 1, orphan receptor
Location	22q11.21
Position	chr22:21369316-21383119, +
External Links	HGNC: 8538 Entrez Gene: 9127 Ensembl: ENSG00000099957 UCSC: uc010gsu.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 3)

ID	Location	Size	Band	Type
CNV_Jarick[2012]_41	chr22:17616020-19792353 (NCBI36 / hg18)	2176334	22q11.21	dup
CNV_Jarick[2012]_42	chr22:19066315-19792353 (NCBI36 / hg18)	726039	22q11.21	dup
CNV_Jarick[2012]_40	chr22:17257787-19792353 (NCBI36 / hg18)	2534567	22q11.21	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006810	transport	Biological Process	TAS[9242461]	62
GO:0006812	cation transport	Biological Process		8
GO:0005737	cytoplasm	Cellular Component	IDA[12088286]	690
GO:0005887	integral to plasma membrane	Cellular Component	TAS[9242461]	220
GO:0004931	extracellular ATP-gated cation channel activity	Molecular Function	NAS[12088286]	2
GO:0005524	ATP binding	Molecular Function	NAS[12088286]	228
GO:0001614	purinergic nucleotide receptor activity	Molecular Function	NAS[12088286]	2
GO:0004888	transmembrane signaling receptor activity	Molecular Function	TAS[9242461]	20
GO:0042802	identical protein binding	Molecular Function	IPI[15313628]	70
GO:0043025	neuronal cell body	Cellular Component		51
GO:0030054	cell junction	Cellular Component	IDA[12088286]	77
GO:0035590	purinergic nucleotide receptor signaling pathway	Biological Process	NAS[12088286]	2
GO:0014069	postsynaptic density	Cellular Component		23
GO:0015267	channel activity	Molecular Function	TAS[9242461]	2
GO:0006936	muscle contraction	Biological Process	TAS[9242461]	18
GO:0007165	signal transduction	Biological Process	TAS[9242461]	171
GO:0051291	protein heterooligomerization	Biological Process		10
GO:0051260	protein homooligomerization	Biological Process	IPI[15313628]	34

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04020	Calcium signaling pathway	63	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). More...

Genes shared at least 5 GO terms with P2RX6 (count: 3)

Gene Symbol	Pathway Count	Pathway List
P2RX3	10	transport; cation transport; integral to plasma membrane; extracellular ATP-gated cation channel activity; ATP binding; purinergic nucleotide receptor activity; neuronal cell body; purinergic nucleotide receptor signaling pathway; signal transduction; protein homooligomerization;
PRKD1	5	cytoplasm; integral to plasma membrane; ATP binding; identical protein binding; signal transduction;
RIPK3	5	ATP binding; identical protein binding; signal transduction; protein heterooligomerization; protein homooligomerization;

Genes shared at least 2 KEGG pathways with P2RX6 (count: 30)

Gene Symbol	Pathway Count	Pathway List
ADORA2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1B	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRA1D	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
ADRB3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
BDKRB2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKAR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CCKBR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
CHRNA7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
DRD5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
EDNRA	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRIN2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM1	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
GRM5	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR2C	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR4	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR5A	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR6	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
HTR7	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
LTB4R2	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
OXTR	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
P2RX3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;
TACR3	2	Neuroactive ligand-receptor interaction; Calcium signaling pathway;

View in gBrowse

Region: chr22:21369316..21383119 View in gBrowse