ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PC
Symbol Alias	PCB
Approved Name	pyruvate carboxylase
Location	11q13.4-q13.5
Position	chr11:66615704-66725847, -
External Links	HGNC: 8636 Entrez Gene: 5091 Ensembl: ENSG00000173599 UCSC: uc001ojn.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009374	biotin binding	Molecular Function		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0046872	metal ion binding	Molecular Function		170
GO:0006090	pyruvate metabolic process	Biological Process		3
GO:0006094	gluconeogenesis	Biological Process		6
GO:0006107	oxaloacetate metabolic process	Biological Process		2
GO:0006629	lipid metabolic process	Biological Process		51
GO:0005743	mitochondrial inner membrane	Cellular Component		44
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0006006	glucose metabolic process	Biological Process		19
GO:0005739	mitochondrion	Cellular Component	IDA[16729965]	183
GO:0005524	ATP binding	Molecular Function		228
GO:0004736	pyruvate carboxylase activity	Molecular Function		1
GO:0004075	biotin carboxylase activity	Molecular Function		2
GO:0003677	DNA binding	Molecular Function		220

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00020	Citrate cycle (TCA cycle)	3	The citrate cycle (TCA cycle, Krebs cycle) is an important a...... The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011]. More...
hsa00620	Pyruvate metabolism	7

Genes shared at least 5 GO terms with PC (count: 6)

Gene Symbol	Pathway Count	Pathway List
ACACA	5	small molecule metabolic process; metal ion binding; mitochondrion; ATP binding; biotin carboxylase activity;
ACAT1	5	small molecule metabolic process; metal ion binding; mitochondrial inner membrane; mitochondrial matrix; mitochondrion;
ACSM2B	5	small molecule metabolic process; metal ion binding; mitochondrial matrix; mitochondrion; ATP binding;
FBP1	5	small molecule metabolic process; metal ion binding; gluconeogenesis; carbohydrate metabolic process; glucose metabolic process;
FBP2	5	small molecule metabolic process; metal ion binding; gluconeogenesis; carbohydrate metabolic process; glucose metabolic process;
SLC25A1	5	small molecule metabolic process; gluconeogenesis; mitochondrial inner membrane; carbohydrate metabolic process; glucose metabolic process;

Genes shared at least 2 KEGG pathways with PC (count: 6)

Gene Symbol	Pathway Count	Pathway List
DLAT	3	Metabolic pathways; Citrate cycle (TCA cycle); Pyruvate metabolism;
ACACA	2	Metabolic pathways; Pyruvate metabolism;
ACAT1	2	Metabolic pathways; Pyruvate metabolism;
ALDH3A2	2	Metabolic pathways; Pyruvate metabolism;
ME3	2	Metabolic pathways; Pyruvate metabolism;
SDHD	2	Metabolic pathways; Citrate cycle (TCA cycle);

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Region: chr11:66615704..66725847 View in gBrowse