ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PGRMC2
Symbol Alias	PMBP, DG6
Approved Name	progesterone receptor membrane component 2
Location	4q26
Position	chr4:129190392-129209984, -
External Links	HGNC: 16089 Entrez Gene: 10424 Ensembl: ENSG00000164040 UCSC: uc003igg.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs4549394	Chr4:129431298(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043401	steroid hormone mediated signaling pathway	Biological Process	TAS[9705155]	1
GO:0020037	heme binding	Molecular Function		23
GO:0016021	integral to membrane	Cellular Component		845
GO:0005496	steroid binding	Molecular Function		7
GO:0003707	steroid hormone receptor activity	Molecular Function	TAS[9705155]	9

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PGRMC2 (count: 0)

Genes shared at least 2 KEGG pathways with PGRMC2 (count: 0)

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Region: chr4:129190392..129209984 View in gBrowse