ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PHLDA1
Symbol Alias	TDAG51, DT1P1B11, PHRIP
Approved Name	pleckstrin homology-like domain, family A, member 1
Name Alias	proline-histidine rich protein
Location	12q15
Position	chr12:76419227-76425556, -
External Links	HGNC: 8933 Entrez Gene: 22822 Ensembl: ENSG00000139289 UCSC: uc001sxu.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1623319	Chr12:76270756(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045210	FasL biosynthetic process	Biological Process		1
GO:0006917	induction of apoptosis	Biological Process		31
GO:0030659	cytoplasmic vesicle membrane	Cellular Component		18
GO:0005886	plasma membrane	Cellular Component		772
GO:0006915	apoptotic process	Biological Process		111
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0005543	phospholipid binding	Molecular Function		61
GO:0005515	protein binding	Molecular Function	IPI[19060904]	910

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PHLDA1 (count: 5)

Gene Symbol	Pathway Count	Pathway List
DAXX	5	induction of apoptosis; apoptotic process; nucleus; nucleolus; protein binding;
MAPK1	5	induction of apoptosis; apoptotic process; nucleus; nucleolus; protein binding;
PERP	5	induction of apoptosis; plasma membrane; apoptotic process; nucleus; nucleolus;
WWOX	5	induction of apoptosis; plasma membrane; apoptotic process; nucleus; protein binding;
PRKD1	5	plasma membrane; apoptotic process; nucleus; phospholipid binding; protein binding;

Genes shared at least 2 KEGG pathways with PHLDA1 (count: 0)

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Region: chr12:76419227..76425556 View in gBrowse